Tag: Wet granulation process for tablets​

Preventing API Loss During High-Speed Granulation Effective Strategies for Preventing API Loss During High-Speed Granulation Overview: High-speed granulation is a widely used process in the pharmaceutical industry to improve the flowability, compressibility, and uniformity of powders used in tablet formulations. While this technique is essential for ensuring optimal tablet characteristics, it can also lead to…

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Challenges in Cleaning Coating Pans After Sugar-Coating Effective Strategies for Cleaning Coating Pans After Sugar-Coating Overview: Coating pans are essential equipment in the pharmaceutical industry used for applying coatings to tablets. After the sugar-coating process, cleaning the coating pan thoroughly becomes a critical task to ensure that cross-contamination does not occur in subsequent batches and…

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Addressing Layer Separation in Bilayer Tablets During Compression Effective Strategies for Addressing Layer Separation in Bilayer Tablets During Compression Overview: Bilayer tablets are a popular formulation in the pharmaceutical industry, offering controlled release of two different active pharmaceutical ingredients (APIs) or distinct release profiles for a single API. However, one common issue faced during the…

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Managing Coating Layer Flaking in Sugar-Coated Tablets Effective Strategies for Managing Coating Layer Flaking in Sugar-Coated Tablets Overview: Sugar-coated tablets are commonly used in the pharmaceutical industry due to their ability to mask unpleasant tastes, enhance tablet appearance, and provide a protective barrier for the active pharmaceutical ingredient (API). However, one of the common issues…

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Preventing Powder Segregation in Vibratory Feeders Effective Strategies for Preventing Powder Segregation in Vibratory Feeders Overview: In pharmaceutical tablet manufacturing, uniformity of powder mixture is crucial for achieving consistent dosage and tablet quality. Vibratory feeders are often used to transport powders into the tablet press, but one of the common challenges in this process is…

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Controlling Residual Moisture in Enteric-Coated Tablets Effective Strategies for Controlling Residual Moisture in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from stomach acid and to deliver it in the intestine where the drug is absorbed. However, one of the challenges associated with the manufacturing of enteric-coated tablets is…

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Addressing Powder Bridging in Tablet Press Hoppers Effective Strategies for Addressing Powder Bridging in Tablet Press Hoppers Overview: Tablet manufacturing involves the use of various excipients and active pharmaceutical ingredients (APIs) in powder form. These powders are fed into the tablet press hoppers, where they are compressed into tablets. A common issue faced during this…

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Preventing Weight Loss in Hygroscopic Tablets During Drying Effective Strategies for Preventing Weight Loss in Hygroscopic Tablets During Drying Overview: Hygroscopic tablets, which absorb moisture from the air, present unique challenges during the drying process in tablet manufacturing. The weight loss that occurs in hygroscopic tablets during drying can affect both the quality of the…

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Ensuring Effective Coating Adhesion in Sustained Release Tablets Effective Strategies for Ensuring Coating Adhesion in Sustained Release Tablets Overview: Sustained release tablets are designed to deliver a drug at a controlled rate over an extended period. The coating used in these tablets is critical for ensuring the release of the drug according to the desired…

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Controlling Overdrying During Post-Coating Processes Effective Strategies for Controlling Overdrying During Post-Coating Processes Overview: The post-coating process is a crucial step in tablet production where tablets are dried after the application of coatings. During this process, the tablets need to be dried thoroughly to remove excess solvent and moisture from the coating, ensuring the final…

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Troubleshooting Spray Nozzle Clogging in Coating Machines Effective Strategies for Troubleshooting Spray Nozzle Clogging in Coating Machines Overview: Coating machines are crucial for the pharmaceutical manufacturing process, as they apply protective or functional coatings to tablets. A common issue that can arise during the coating process is spray nozzle clogging. This problem can result in…

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Avoiding Heat Degradation of APIs in Compression Stages Effective Strategies for Avoiding Heat Degradation of APIs in Compression Stages Overview: Active Pharmaceutical Ingredients (APIs) are sensitive to various environmental factors, and one of the most critical factors is heat. Heat degradation can significantly affect the stability, potency, and efficacy of APIs. In pharmaceutical manufacturing, especially…

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