Tag: Wet granulation process for tablets​

Designing Tablets with Resistance to Crushing for Controlled Release Expert Guide to Formulating Crush-Resistant Tablets for Controlled Drug Release Overview: Pharmaceutical tablets with controlled release properties must be designed to resist crushing and tampering to ensure proper drug delivery and prevent misuse. Many controlled-release (CR) formulations, including opioids, psychotropic medications, and high-potency drugs, are prone…

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Addressing Non-Uniform Tablet Thickness in Immediate Release Tablets Step-by-Step Guide to Resolving Non-Uniform Tablet Thickness in Immediate Release Tablets Overview: Non-uniform tablet thickness is a critical issue in immediate release (IR) tablet manufacturing, affecting tablet weight uniformity, dissolution rates, and patient compliance. Variations in thickness can result from inconsistencies in powder flow, compression force, die…

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Role of Modified Release Excipients in Tablet Formulations Exploring the Role of Modified Release Excipients in Tablet Formulations Overview: Modified release (MR) excipients play a crucial role in controlling drug release rates, improving bioavailability, and enhancing patient compliance. These excipients enable extended, sustained, or targeted drug delivery, ensuring a consistent therapeutic effect while reducing side…

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Addressing Hydration-Related Issues in Coated Tablet Formulations Step-by-Step Guide to Overcoming Hydration-Related Challenges in Coated Tablet Formulations Overview: Hydration-related issues in coated tablets are a common challenge in pharmaceutical manufacturing, affecting film integrity, drug stability, and release profiles. Moisture from the environment or the coating process itself can lead to film softening, swelling, tackiness, and…

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Selection of Dispersing Agents in High-Dose API Formulations Latest Advances in Selecting Dispersing Agents for High-Dose API Formulations Overview: Formulating high-dose active pharmaceutical ingredient (API) tablets presents significant challenges due to poor powder flow, compression issues, and inconsistent drug release. One of the key formulation strategies to overcome these issues is the selection of appropriate…

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Managing Compatibility Issues Between Coating Layers in Multi-Layer Tablets Expert Guide to Managing Compatibility Issues Between Coating Layers in Multi-Layer Tablets Overview: Multi-layer tablets are increasingly used in pharmaceutical formulations to combine multiple APIs, enhance controlled release, and improve patient compliance. However, achieving compatibility between different coating layers is a major challenge. Issues such as…

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Troubleshooting Film Coating Defects in Tablets with High Surface Area How to Fix Film Coating Defects in Tablets with High Surface Area Overview: Film coating is an essential process in tablet manufacturing for improving drug stability, controlling release, and enhancing aesthetics. However, tablets with high surface area (e.g., large, porous, or highly friable tablets) pose…

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Overcoming Challenges in Formulating Tablets for Pediatric Use Step-by-Step Guide to Developing Pediatric Tablets with Improved Compliance Overview: Developing tablets for pediatric use presents unique challenges, including dose flexibility, taste masking, ease of swallowing, and safety. Children have different physiological responses, difficulty swallowing solid dosage forms, and a preference for palatable medications. Pediatric formulations must…

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Formulation of Enteric-Coated Tablets with Dual pH-Release Profiles Expert Guide to Developing Enteric-Coated Tablets with Dual pH-Release Profiles Overview: Enteric-coated tablets are designed to protect APIs from gastric degradation and ensure site-specific drug release. While traditional enteric coatings enable drug release in the intestine, newer formulations are being developed to provide dual pH-release profiles, allowing…

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Optimization of Anti-Adherent Agents in Film Coating Step-by-Step Guide to Optimizing Anti-Adherent Agents in Film Coating Overview: Film coating is an essential step in tablet manufacturing, improving drug stability, taste masking, and controlled drug release. However, one of the most common issues faced during coating is tablet sticking and adhesion, leading to poor-quality coatings, inconsistent…

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Managing Heat Sensitivity in Sustained Release Tablet Coating Innovative Approaches to Managing Heat Sensitivity in Sustained Release Tablet Coating Overview: Coating of sustained release (SR) tablets plays a critical role in controlling drug release, protecting active pharmaceutical ingredients (APIs), and enhancing patient compliance. However, heat sensitivity of certain APIs and excipients presents significant challenges, particularly…

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Troubleshooting Core Erosion During Coating Processes How to Troubleshoot and Prevent Core Erosion in Tablet Coating Overview: Core erosion during the tablet coating process is a significant issue that can lead to loss of drug content, reduced mechanical strength, irregular drug release, and aesthetic defects. This occurs when the core loses its structural integrity due…

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