Tag: Tablets

How to Address Granulation Inconsistencies in Tablet Manufacturing Steps to Resolve Granulation Inconsistencies in Tablet Production What are Granulation Inconsistencies? Granulation inconsistencies occur when granules produced during tablet manufacturing exhibit irregularities in size, density, or moisture content. These inconsistencies lead to issues such as poor powder flow, segregation, uneven die filling, and compromised tablet quality….

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Preventing Tablet Sticking During Compression How to Avoid Tablet Sticking Issues in Compression What is Tablet Sticking? Tablet sticking occurs when powder adheres to the surface of punches during the compression process. This issue results in defective tablets with uneven surfaces, poor aesthetics, and potentially compromised dosage accuracy. Sticking can disrupt production, increase downtime for…

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How to Optimize Particle Size for Better Tablet Compression Effective Strategies to Optimize Particle Size for Tablet Compression Why is Particle Size Important in Tablet Compression? Particle size is a critical factor in tablet manufacturing, influencing powder flowability, compressibility, and tablet quality. Irregular or inappropriate particle size distribution can lead to defects such as poor…

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Managing Static Build-Up in Tablet Processing Lines Effective Strategies to Manage Static Build-Up in Tablet Manufacturing What is Static Build-Up in Tablet Processing Lines? Static build-up occurs when electrical charges accumulate on the surface of materials during the tablet manufacturing process. This is particularly common in dry environments and with fine powders. Static electricity can…

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How to Reduce Over-Lubrication in Tablet Granules Steps to Minimize Over-Lubrication in Tablet Granules What is Over-Lubrication in Tablet Granules? Over-lubrication occurs when excessive lubricants, such as magnesium stearate or talc, are added or mixed for too long with tablet granules. While lubricants are essential for reducing friction during compression and ejection, over-lubrication can weaken…

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Troubleshooting Poor Powder Flow in Tablet Formulations Addressing Common Issues with Powder Flow in Tablet Formulations What Causes Poor Powder Flow in Tablet Formulations? Poor powder flow is a common challenge in tablet manufacturing. It can lead to inconsistent die filling, weight variation, and even machine downtime. This issue typically arises due to factors such…

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How to Prevent Segregation in Tablet Powder Blends Effective Techniques to Avoid Segregation in Tablet Powder Blends What is Segregation in Tablet Powder Blends? Segregation refers to the separation of different components in a powder blend, leading to inconsistencies in tablet composition. This occurs when powders of varying particle sizes, densities, or shapes are mixed…

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Troubleshooting Double-Impression Issues in Tablet Pressing Resolving Double-Impression Problems in Tablet Manufacturing What is Double-Impression in Tablet Pressing? Double-impression occurs when a tablet receives an unintended duplicate marking during the compression process. This defect is primarily associated with improperly functioning punches, where one or both punches move freely in the die and imprint a second…

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How to Avoid Air Entrapment in Tablet Core During Manufacturing Techniques to Prevent Air Entrapment in Tablet Manufacturing Understanding Air Entrapment in Tablets Air entrapment occurs when air pockets are trapped inside the core of a tablet during the compression process. This issue can lead to defects such as capping, lamination, or weakened mechanical strength….

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Preventing Tablet Breakage During High-Speed Compression Effective Strategies to Avoid Tablet Breakage in High-Speed Compression Understanding Tablet Breakage in High-Speed Compression Tablet breakage is a common issue in high-speed tablet compression, where tablets crack, chip, or break during production or handling. The high speeds involved in modern tablet presses exert significant stress on both the…

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How to Optimize Tablet Hardness for Immediate-Release Formulations Optimizing Tablet Hardness for Effective Immediate-Release Formulations Why is Tablet Hardness Important? Tablet hardness plays a crucial role in immediate-release formulations. It directly affects the mechanical strength of the tablet, its disintegration time, and the release of active pharmaceutical ingredients (APIs). Hardness that is too low may…

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Dealing with Excessive Powder Sticking to Punches in Tablet Machines How to Resolve Excessive Powder Sticking Issues in Tablet Press Machines What Causes Powder Sticking to Punches? Powder sticking to punches, commonly known as “sticking,” is a frequent issue in tablet manufacturing. It occurs when powder adheres to the punch faces instead of compacting properly…

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