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Managing Excess Binder Residues in Wet Granulated Powders Expert Guide to Managing Excess Binder Residues in Wet Granulated Powders What Are Excess Binder Residues in Wet Granulated Powders? Excess binder residues occur when the binder used during wet granulation is present in quantities that exceed the optimal amount, leading to issues such as over-wetted granules,…
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Troubleshooting Granule Size Reduction for Immediate-Release Tablets Step-by-Step Guide to Troubleshooting Granule Size Reduction for Immediate-Release Tablets Why is Granule Size Important for Immediate-Release Tablets? Granule size plays a critical role in the manufacturing of immediate-release tablets. Optimal granule size ensures uniform mixing, consistent flowability, and effective tablet compression. When granules become too small or…
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Optimizing Granule Porosity for Tablet Dissolution Profiles How to Optimize Granule Porosity for Tablet Dissolution Profiles What is Granule Porosity and Why is it Important? Granule porosity refers to the volume of void spaces within a granule. It plays a critical role in determining the dissolution rate of tablets, as higher porosity allows faster fluid…
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How to Achieve Consistent Moisture Content in Granules Expert Guide to Achieving Consistent Moisture Content in Granules Why is Consistent Moisture Content Important in Granules? Consistent moisture content in granules is critical for ensuring the quality, flowability, compressibility, and stability of pharmaceutical products. Variability in moisture content can lead to granule segregation, uneven drug release,…
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Preventing Granule Dust Generation in High-Shear Mixing Preventing Granule Dust Generation in High-Shear Mixing What is Granule Dust Generation in High-Shear Mixing? Granule dust generation occurs when fine particles or excessive powder residues are produced during the high-shear mixing process in granulation. This issue can lead to poor flowability, inconsistent granule size, reduced yield, and…
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How to Control Granule Hardness for Improved Tablet Compression How to Control Granule Hardness for Improved Tablet Compression Why is Granule Hardness Important for Tablet Compression? Granule hardness refers to the strength and cohesion of granules produced during the granulation process. Proper granule hardness is essential for achieving uniform compression, optimal tablet hardness, and consistent…
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Managing Granule Segregation During Drying and Milling How to Manage Granule Segregation During Drying and Milling What is Granule Segregation? Granule segregation refers to the separation of particles or granules based on size, density, or composition during processing steps such as drying and milling. Segregation can result in inconsistent granule properties, poor flowability, uneven drug…
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How to Prevent Over-Agglomeration in Fluidized Bed Granulators How to Prevent Over-Agglomeration in Fluidized Bed Granulators What is Over-Agglomeration in Fluidized Bed Granulation? Over-agglomeration refers to the excessive clumping of particles during the granulation process in a fluidized bed granulator. This issue can lead to oversized granules, poor flow properties, uneven drug distribution, and challenges…
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Troubleshooting Poor Binder Distribution in Wet Granulation Troubleshooting Poor Binder Distribution in Wet Granulation What is Poor Binder Distribution in Wet Granulation? Poor binder distribution occurs when the binder, used to ensure granule cohesiveness, is unevenly dispersed throughout the granulated material. This can lead to problems such as inconsistent granule size, weak granules, or excessive…
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How to Optimize Roller Compaction Parameters for Granule Uniformity How to Optimize Roller Compaction Parameters for Granule Uniformity What is Roller Compaction in Granulation? Roller compaction is a dry granulation process used to produce granules by compacting powder blends between two rollers. The resulting compacted ribbons are milled to form granules of the desired size….
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Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets What Are Adhesion Issues in Multi-Layer Coated Tablets? Adhesion issues occur when layers of coating in multi-layer tablets fail to bond properly. This can result in peeling, cracking, or delamination, compromising the tablet’s appearance, functionality, and drug release profile. Adhesion problems…
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How to Avoid Color Mottling in Film-Coated Tablets How to Prevent Color Mottling in Film-Coated Tablets What is Color Mottling in Film-Coated Tablets? Color mottling refers to uneven or patchy color distribution on the surface of film-coated tablets. This defect can negatively impact the aesthetic appeal and perceived quality of pharmaceutical products. Color mottling is…
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