Tag: Tablet press troubleshooting​

Reducing Rejection Rates Due to Cosmetic Defects in Coated Tablets Techniques for Reducing Rejection Rates Due to Cosmetic Defects in Coated Tablets Overview: Cosmetic defects in coated tablets, such as discoloration, streaks, uneven coating, or chips, are a significant issue in the pharmaceutical industry. These defects, while not affecting the efficacy or safety of the…

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Troubleshooting Granulation Issues in Low-Dose API Formulations Strategies for Troubleshooting Granulation Issues in Low-Dose API Formulations Overview: Granulation is a key step in tablet manufacturing that involves the formation of granules from powder particles. This process helps improve the flowability, compressibility, and uniformity of powders. However, granulating low-dose active pharmaceutical ingredients (APIs) presents unique challenges…

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Avoiding Uneven Color Distribution in Sugar-Coated Tablets Techniques for Avoiding Uneven Color Distribution in Sugar-Coated Tablets Overview: In the pharmaceutical industry, sugar coating is commonly used to improve the appearance, taste, and stability of tablets. A uniform and attractive sugar coating is essential for the aesthetic appeal of the product, as well as for ensuring…

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Managing Over-Spray in Film Coating Machines Techniques for Managing Over-Spray in Film Coating Machines Overview: Film coating is a critical process in pharmaceutical tablet production, where a thin layer of coating is applied to the tablet surface to enhance its stability, appearance, and release properties. Over-spray, a common issue in film coating machines, occurs when…

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Controlling Humidity in Coating Rooms for Immediate Release Tablets Techniques for Controlling Humidity in Coating Rooms for Immediate Release Tablets Overview: Humidity control in coating rooms is essential for ensuring the successful application of coatings, particularly for immediate release (IR) tablets. During the tablet coating process, humidity can significantly impact the quality and consistency of…

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Addressing Lamination in Oval and Odd-Shaped Tablets Techniques for Addressing Lamination in Oval and Odd-Shaped Tablets Overview: Lamination, or the separation of layers in tablet compression, is a common issue that can occur during the production of tablets, especially for complex shapes such as oval and irregularly shaped tablets. Lamination occurs when the tablet layers…

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Troubleshooting Core Cracking in Bilayer Tablet Compression Guidelines for Troubleshooting Core Cracking in Bilayer Tablet Compression Overview: Bilayer tablets are an important dosage form in pharmaceutical manufacturing, as they allow for the controlled release of two different active pharmaceutical ingredients (APIs) in a single tablet. This dual-layer structure is particularly useful for combination therapies and…

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Optimizing Spray Uniformity for Multi-Layer Coating Applications Techniques for Optimizing Spray Uniformity in Multi-Layer Coating Applications Overview: Multi-layer coating is an essential process in pharmaceutical manufacturing, particularly when creating tablets with controlled-release profiles, taste masking, or multi-functional coatings. Achieving a uniform spray application is critical to ensuring the consistent quality and performance of multi-layer coated…

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Managing Over-Compression of APIs in High-Speed Presses Techniques for Managing Over-Compression of APIs in High-Speed Presses Overview: Over-compression during tablet manufacturing is a significant challenge, particularly when using high-speed tablet presses. This occurs when excessive compression force is applied to the tablet formulation, resulting in tablets that are overly dense, brittle, or have compromised dissolution…

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Preventing Fines Generation in Spray Drying Processes Guidelines for Preventing Fines Generation in Spray Drying Processes Overview: Spray drying is a widely used technique in the pharmaceutical industry to convert liquid formulations, including suspensions or solutions, into fine powder form. This process involves spraying a liquid feed into a heated chamber where rapid evaporation of…

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Avoiding Granule Attrition During Fluid Bed Drying Techniques for Avoiding Granule Attrition During Fluid Bed Drying Overview: Granule attrition, or the breaking down of granules into smaller particles during processing, is a significant issue in pharmaceutical manufacturing, especially during fluid bed drying. Fluid bed drying is commonly used to remove moisture from granules after the…

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Controlling Spray Rate in Sugar-Coating for Glossy Finish Guidelines for Controlling Spray Rate in Sugar-Coating for a Glossy Finish Overview: In tablet manufacturing, sugar coating plays a crucial role in enhancing the aesthetic appeal, masking undesirable tastes, and providing stability to the active pharmaceutical ingredient (API). One of the most desired characteristics of sugar-coated tablets…

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