Tag: Tablet press troubleshooting​

Excipient-Drug Interaction Studies in Extended Release Tablets A Step-by-Step Guide to Excipient-Drug Interaction Studies in Extended Release Tablets Overview: Excipient-drug interactions are a crucial consideration in the development of extended release (ER) tablets. The selection of excipients, including binders, fillers, disintegrants, and polymers, can significantly affect the release profile of the active pharmaceutical ingredient (API)….

Read More “Excipient-Drug Interaction Studies in Extended Release Tablets” »

Role of Pre-Formulation Studies in Tablet Development The Importance of Pre-Formulation Studies in Tablet Development Overview: Pre-formulation studies are a critical phase in the development of pharmaceutical tablets. These studies involve assessing the physical and chemical properties of the active pharmaceutical ingredient (API) and excipients, which serve as the foundation for successful tablet formulation. The…

Read More “Role of Pre-Formulation Studies in Tablet Development” »

Strategies to Minimize Friability in Tablets During Development Effective Strategies to Minimize Friability in Tablets During Development Overview: Friability is a critical factor in tablet formulation, referring to the tendency of tablets to break or crumble under stress during handling, transport, and storage. A high friability rate indicates poor tablet strength and can lead to…

Read More “Strategies to Minimize Friability in Tablets During Development” »

Formulation Challenges in Orally Disintegrating Tablets Overcoming Formulation Challenges in Orally Disintegrating Tablets Overview: Orally disintegrating tablets (ODTs) are designed to dissolve or disintegrate rapidly in the mouth without the need for water, offering an easy-to-administer option for patients, especially those with swallowing difficulties. ODTs are commonly used for pediatric, geriatric, and certain psychiatric medications,…

Read More “Formulation Challenges in Orally Disintegrating Tablets” »

Achieving Consistent Release Profiles in Sustained Release Tablets Strategies for Achieving Consistent Release Profiles in Sustained Release Tablets Overview: Sustained release (SR) tablets are designed to release the active pharmaceutical ingredient (API) over an extended period, allowing for more consistent therapeutic effects with fewer doses. Achieving consistent release profiles in SR tablets is critical to…

Read More “Achieving Consistent Release Profiles in Sustained Release Tablets” »

Issues with Overuse of Coating Polymers in Sugar-Coated Tablets Addressing the Challenges of Overuse of Coating Polymers in Sugar-Coated Tablets Overview: Sugar coating is a popular tablet formulation technique that provides a protective layer around the active pharmaceutical ingredient (API). This coating improves tablet appearance, masks unpleasant taste, and protects the API from environmental factors….

Read More “Issues with Overuse of Coating Polymers in Sugar-Coated Tablets” »

Stability of APIs in Film-Coated Tablet Formulations Ensuring API Stability in Film-Coated Tablet Formulations Overview: The stability of active pharmaceutical ingredients (APIs) in film-coated tablet formulations is a key factor in ensuring the safety, efficacy, and shelf-life of the final product. Film coating is a widely used technique in pharmaceutical tablet formulation to protect the…

Read More “Stability of APIs in Film-Coated Tablet Formulations” »

Overcoming Challenges in Solubility Enhancement for Immediate Release Tablets Effective Strategies for Enhancing Solubility in Immediate Release Tablets Overview: Solubility is one of the most significant challenges in pharmaceutical formulation, particularly when developing immediate release (IR) tablets. The solubility of the active pharmaceutical ingredient (API) directly impacts its bioavailability and therapeutic efficacy. For poorly soluble…

Read More “Overcoming Challenges in Solubility Enhancement for Immediate Release Tablets” »

Selecting Fillers for Better Tablet Compactibility Optimizing Filler Selection for Enhanced Tablet Compactibility Overview: In pharmaceutical tablet formulation, fillers (also known as excipients or diluents) are an essential component used to add bulk to tablets containing small amounts of active pharmaceutical ingredients (APIs). Proper selection of fillers is crucial, as they influence the tablet’s compactibility,…

Read More “Selecting Fillers for Better Tablet Compactibility” »

Challenges in Formulation of Immediate Release Tablets Overcoming Formulation Challenges in Immediate Release Tablets Overview: The formulation of immediate release (IR) tablets is a critical aspect of pharmaceutical dosage form development. These tablets are designed to release their active pharmaceutical ingredients (APIs) rapidly upon ingestion, ensuring fast onset of action. However, formulating these tablets presents…

Read More “Challenges in Formulation of Immediate Release Tablets” »