Tag: Tablet press troubleshooting​

API Degradation in Sugar-Coated Tablet Formulations: Prevention Strategies Preventing API Degradation in Sugar-Coated Tablet Formulations Overview: Sugar coating has been a traditional approach in pharmaceutical tablet formulation, providing benefits such as taste masking, improved stability, and enhanced visual appeal. However, one of the key challenges associated with sugar-coated tablets is the risk of API (Active…

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Addressing Layer Adhesion Problems in Multi-Layer Tablets Step-by-Step Guide: Addressing Layer Adhesion Problems in Multi-Layer Tablets Overview: Multi-layer tablets are commonly used in pharmaceutical formulations to separate incompatible drugs, control release profiles, or combine multiple active pharmaceutical ingredients (APIs). However, a major challenge in their manufacturing is poor layer adhesion, which can lead to delamination,…

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Selecting the Optimal Binder for Granulation Processes Expert Guide: Selecting the Optimal Binder for Granulation Processes Overview: Granulation is a crucial step in pharmaceutical tablet manufacturing, ensuring proper powder flowability, compressibility, and uniformity. The selection of a suitable binder is critical to achieving the desired granule characteristics, as binders help in particle adhesion, mechanical strength,…

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Preventing Tablet Capping in Formulation Stages Troubleshooting and How-To Guide: Preventing Tablet Capping in Formulation Stages Overview: Tablet capping is a common issue in pharmaceutical manufacturing where the upper or lower surface of a tablet detaches or separates during ejection or handling. Capping is a serious defect that compromises tablet integrity, drug release, and patient…

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Achieving Consistency in Tablet Weight During Formulation Development Step-by-Step Guide: Ensuring Consistent Tablet Weight in Formulation Development Overview: Consistency in tablet weight is a critical factor in pharmaceutical manufacturing. Variations in tablet weight can lead to dosage inaccuracies, affecting drug efficacy and patient safety. Regulatory agencies such as the FDA and EMA have stringent guidelines…

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Role of Functional Polymers in Extended Release Tablets Research & Trends: The Role of Functional Polymers in Extended Release Tablets Overview: Extended-release (ER) tablets are designed to maintain therapeutic drug levels in the bloodstream for a prolonged period, reducing dosing frequency and improving patient compliance. A key component in these formulations is the use of…

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Designing Bilayer Tablets for Complex Release Patterns Step-by-Step Guide: Designing Bilayer Tablets for Complex Release Patterns Overview: Bilayer tablets have emerged as an innovative solution for delivering drugs with complex release patterns. These tablets consist of two distinct layers, each designed to release the active pharmaceutical ingredient (API) at different rates or in different parts…

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Incorporating Multi-Unit Systems in Sustained Release Tablets Expert Guide: Incorporating Multi-Unit Systems in Sustained Release Tablets Overview: Multi-unit systems in sustained release (SR) tablets have gained prominence in pharmaceutical formulation due to their advantages over single-unit dosage forms. These systems consist of multiple small drug-containing units, such as pellets, mini-tablets, or granules, that allow for…

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Troubleshooting Swelling Issues in Sustained Release Tablets DIY and Step-by-Step Guide: Troubleshooting Swelling Issues in Sustained Release Tablets Overview: Swelling issues in sustained release (SR) tablets can significantly impact the drug release profile, leading to inconsistent dosing and therapeutic failure. Sustained release formulations are designed to release the active pharmaceutical ingredient (API) gradually over time,…

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Problems with Film Thickness Uniformity in Coated Tablets Troubleshooting and How-To Guide: Problems with Film Thickness Uniformity in Coated Tablets Overview: Film-coated tablets are commonly used in the pharmaceutical industry to enhance the stability, appearance, and release profile of drugs. However, achieving uniform film thickness during the coating process can be a significant challenge. Variations…

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Enhancing Bioavailability in Enteric-Coated Tablets Research & Trends: Enhancing Bioavailability in Enteric-Coated Tablets Overview: Bioavailability, the proportion of a drug that enters the systemic circulation in an active form, is a critical factor in the design of effective pharmaceutical formulations. In the case of enteric-coated tablets, bioavailability can be significantly impacted by the coating, which…

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Role of Controlled Particle Size in Tablet Compression Case Study: The Role of Controlled Particle Size in Tablet Compression Overview: Tablet compression is a critical step in tablet formulation, affecting both the physical properties and performance of the final product. One of the key factors influencing compression is the particle size of the powders used…

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