Tag: Tablet press troubleshooting​

Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Understanding the Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Overview: The use of hydrophilic polymers in sustained-release (SR) tablet formulations has revolutionized drug delivery by enabling controlled drug release, improved patient compliance, and enhanced bioavailability. These polymers play a crucial role in modulating drug…

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Addressing Low Compressibility of Certain APIs in Tablet Formulations Expert Guide to Overcoming Low Compressibility of Certain APIs in Tablet Formulations Overview: Compressibility is a critical factor in tablet manufacturing, as it determines the ability of a powder blend to form a mechanically strong tablet under compression. Many active pharmaceutical ingredients (APIs) exhibit low compressibility…

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Managing Solvent Residues in Film-Coated Tablet Processes Step-by-Step Guide to Managing Solvent Residues in Film-Coated Tablet Processes Overview: Solvent-based film coating is widely used in pharmaceutical manufacturing to provide tablet protection, controlled drug release, and improved stability. However, residual solvents left behind after the coating process can pose significant concerns, including toxicity, regulatory non-compliance, altered…

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Troubleshooting Grittiness in Sugar-Coated Tablets How to Troubleshoot Grittiness in Sugar-Coated Tablets Overview: Sugar-coating is a widely used technique in pharmaceutical tablet manufacturing to improve appearance, mask taste, and enhance stability. However, a common issue faced during sugar coating is the occurrence of grittiness, which results in a rough or uneven surface. This defect can…

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Challenges in Combining Immediate and Sustained Release Profiles in One Tablet Expert Guide to Overcoming Challenges in Combining Immediate and Sustained Release Profiles in One Tablet Overview: Developing a dual-release tablet that combines both immediate release (IR) and sustained release (SR) drug profiles presents several formulation and manufacturing challenges. These dosage forms are designed to…

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Optimizing Disintegration Time for Immediate Release Tablets Step-by-Step Guide to Optimizing Disintegration Time for Immediate Release Tablets Overview: Immediate release (IR) tablets are designed to disintegrate rapidly in the gastrointestinal tract, ensuring fast drug absorption and onset of action. The disintegration time of an IR tablet is a critical quality attribute that directly influences dissolution,…

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Effect of Surfactants on the Dissolution Rate of Extended Release Tablets Understanding the Effect of Surfactants on the Dissolution Rate of Extended Release Tablets Overview: Surfactants play a significant role in pharmaceutical formulations, particularly in modulating the dissolution rate of extended-release (ER) tablets. In ER formulations, achieving a controlled and predictable drug release profile is…

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Addressing Uniformity of Coating Weight Across Batch Sizes Step-by-Step Guide to Achieving Uniformity in Coating Weight Across Batch Sizes Overview: Uniform coating weight is critical in pharmaceutical tablet manufacturing to ensure consistent drug release, aesthetic appeal, and tablet stability. Variations in coating weight across different batch sizes can lead to dosage inconsistency, poor adhesion, and…

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Overcoming Brittleness in Tablets Containing Large API Molecules Strategies to Overcome Brittleness in Tablets Containing Large API Molecules Overview: One of the major challenges in tablet formulation is ensuring sufficient mechanical strength while maintaining desired dissolution and disintegration properties. Tablets containing large API molecules often exhibit increased brittleness due to poor compressibility, weak interparticle bonding,…

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Preventing Sticking During the Compression of Immediate Release Tablets How to Prevent Sticking Issues During the Compression of Immediate Release Tablets Overview: Sticking during tablet compression is a common problem in immediate release (IR) tablet manufacturing. It occurs when the tablet material adheres to the punch surfaces instead of forming a smooth tablet surface. This…

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Managing Particle Size Distribution in Film-Coated Tablets Effective Strategies for Managing Particle Size Distribution in Film-Coated Tablets Overview: Particle size distribution (PSD) plays a crucial role in the manufacturing and performance of film-coated tablets. Variations in particle size can affect tablet compressibility, flowability, coating uniformity, and dissolution rates. Poor PSD control may result in coating…

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Impact of Polymer Type on Delayed-Release Profiles in Enteric Tablets Understanding the Impact of Polymer Type on Delayed-Release Profiles in Enteric Tablets Overview: Enteric-coated tablets are designed to protect acid-sensitive drugs from degradation in the stomach and ensure targeted drug release in the intestine. The success of enteric formulations largely depends on the choice of…

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