Tag: Tablet manufacturing process​

Troubleshooting Adhesion Failure in Enteric-Coated Tablets Effective Strategies for Troubleshooting Adhesion Failure in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from degradation in the stomach and to ensure that the drug is released in the intestines. However, one common issue in the production of enteric-coated tablets is adhesion…

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Reducing Electrostatic Charge in Powder Blending Effective Solutions for Reducing Electrostatic Charge in Powder Blending Overview: Electrostatic charge accumulation in powder blends is a significant challenge in pharmaceutical manufacturing, especially during processes like powder blending. This charge can lead to powder clumping, inconsistent flow, and poor blend uniformity, which ultimately affects tablet formation and product…

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Preventing Overloading in Tablet Press Hoppers Effective Strategies for Preventing Overloading in Tablet Press Hoppers Overview: Overloading in tablet press hoppers is a common issue in tablet manufacturing that can lead to a variety of operational problems, such as inconsistent tablet weight, reduced tablet quality, and increased wear and tear on equipment. The hopper is…

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Addressing Over-Lubrication Issues in Tablet Manufacturing Effective Solutions for Addressing Over-Lubrication Issues in Tablet Manufacturing Overview: Lubrication plays a critical role in tablet manufacturing by reducing friction between the tablet material and the compression equipment, facilitating smooth tablet ejection, and preventing sticking during the compression process. However, excessive lubrication, known as over-lubrication, can lead to…

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Managing Spray Uniformity in Film Coating Machines Effective Approaches for Managing Spray Uniformity in Film Coating Machines Overview: Film coating is a critical step in pharmaceutical tablet manufacturing that applies a thin, uniform coating to the tablet’s surface to protect the active pharmaceutical ingredient (API), mask the taste, and control drug release. However, achieving uniform…

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Preventing Tablet Chipping During Compression Effective Strategies for Preventing Tablet Chipping During Compression Overview: Tablet chipping is a common issue encountered during tablet compression, where fragments of the tablet break off at the edges, resulting in defects and compromised product quality. This problem not only affects the appearance of the tablets but can also lead…

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Dealing with Agglomeration During Wet Granulation Step-by-Step Guide to Dealing with Agglomeration During Wet Granulation Overview: Wet granulation is a key technique in pharmaceutical tablet manufacturing, where powders are agglomerated to improve the flowability, compressibility, and homogeneity of the blend. However, a common issue faced during this process is agglomeration, which refers to the unwanted…

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Managing Humidity in Compression Areas of Hygroscopic Tablets Step-by-Step Guide to Managing Humidity in Compression Areas of Hygroscopic Tablets Overview: Hygroscopic tablets are particularly sensitive to moisture in the environment, as they tend to absorb water from the air. This moisture absorption can lead to changes in the tablet’s properties, such as increased weight variation,…

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Overcoming Heat Build-Up in Sustained Release Tablet Granulation Step-by-Step Guide to Overcoming Heat Build-Up in Sustained Release Tablet Granulation Overview: Granulation is a crucial step in the manufacturing of sustained release tablets, where powders are bound together to form granules that are then compressed into tablets. During this process, heat build-up is a common issue,…

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Resolving Flowability Issues in Tablet Press Feed Frames Step-by-Step Guide to Resolving Flowability Issues in Tablet Press Feed Frames Overview: Flowability is a crucial property in tablet manufacturing, especially in the context of tablet press feed frames. The feed frame of a tablet press holds the powder blend and delivers it to the die cavity…

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Real-Time Monitoring in Roller Compaction for Granules Step-by-Step Guide to Real-Time Monitoring in Roller Compaction for Granules Overview: Roller compaction is an essential dry granulation technique used in pharmaceutical manufacturing to improve the flow and compressibility of powders, making it easier to form tablets. However, controlling the process in real time is critical to ensure…

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Prevention of Picking and Sticking in Enteric-Coated Tablets Step-by-Step Guide to Preventing Picking and Sticking in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from stomach acids and ensure that the drug is released in the intestines. However, during the coating process, common issues such as picking and sticking…

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