Tag: Tablet manufacturing process​

Managing Uneven Coating Distribution in Sugar-Coated Tablets Effective Strategies for Managing Uneven Coating Distribution in Sugar-Coated Tablets Overview: Sugar coating is a critical process in the pharmaceutical industry, used to provide a protective layer, enhance appearance, and improve the palatability of tablets. However, one common issue that can arise during sugar coating is uneven coating…

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Preventing Premature Release of APIs in Controlled Release Tablets Effective Strategies for Preventing Premature Release of APIs in Controlled Release Tablets Overview: Controlled release (CR) tablets are designed to release their active pharmaceutical ingredient (API) gradually over an extended period of time to improve therapeutic efficacy and patient compliance. However, premature release of the API…

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Addressing Uneven Coating Distribution in Sugar-Coated Tablets Effective Strategies for Addressing Uneven Coating Distribution in Sugar-Coated Tablets Overview: Sugar coating is widely used in the pharmaceutical industry to enhance the appearance, taste, and stability of tablets. However, uneven coating distribution is a common issue that can lead to cosmetic defects, inconsistent drug release, and compromised…

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Optimizing Tablet Yield in Continuous Manufacturing Processes Effective Strategies for Optimizing Tablet Yield in Continuous Manufacturing Processes Overview: Tablet manufacturing is a complex process that involves numerous steps, including blending, granulation, compression, and coating. With the increasing demand for pharmaceutical products, manufacturers are moving toward continuous manufacturing processes to improve efficiency and reduce costs. Continuous…

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Controlling Fines During Tablet Compression Effective Strategies for Controlling Fines During Tablet Compression Overview: Tablet compression is a vital process in pharmaceutical manufacturing, where powder blends are compacted into tablets. During this process, fine particles, or fines, are often produced, which can adversely affect tablet quality. Fines are smaller particles that are generated when larger…

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Managing Compression Variability Due to Lubricant Overuse Effective Strategies for Managing Compression Variability Due to Lubricant Overuse Overview: Tablet compression is a critical process in pharmaceutical manufacturing, where powders or granules are compacted into tablets using mechanical pressure. Lubricants are often added to tablet formulations to improve flowability, prevent sticking, and reduce friction during the…

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Optimizing Spray Gun Settings for Uniform Coating Thickness Effective Strategies for Optimizing Spray Gun Settings for Uniform Coating Thickness Overview: Spray coating is a critical step in the pharmaceutical manufacturing process, particularly when applying coatings to tablets. Achieving a uniform coating thickness is essential to ensure consistent drug release, tablet integrity, and product aesthetics. However,…

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Addressing Core Erosion During Sugar Coating Effective Strategies for Addressing Core Erosion During Sugar Coating Overview: Sugar coating is a widely used technique in pharmaceutical manufacturing to coat tablets, providing them with a sweet taste, a smooth finish, and protection against environmental factors. However, one of the challenges faced during the sugar-coating process is core…

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Impact of Particle Size on Tablet Compaction and Compression Understanding the Impact of Particle Size on Tablet Compaction and Compression Overview: Tablet compaction and compression are critical steps in pharmaceutical manufacturing that directly influence tablet quality, including hardness, dissolution, and bioavailability. The size and distribution of the particles in the powder blend used for tablet…

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Troubleshooting Granule Segregation in Fluidized Beds Effective Strategies for Troubleshooting Granule Segregation in Fluidized Beds Overview: Granule segregation is a common issue in the pharmaceutical manufacturing process, particularly during the drying and granulation stages. This problem becomes even more pronounced in fluidized bed systems, where powders or granules are suspended and dried through the flow…

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Managing Cross-Contamination Risks in Shared Manufacturing Facilities Effective Strategies for Managing Cross-Contamination Risks in Shared Manufacturing Facilities Overview: In pharmaceutical manufacturing, cross-contamination poses a significant risk, especially in facilities where multiple products are manufactured in the same space. The unintended transfer of substances from one product batch to another can lead to serious consequences such…

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Role of Anti-Tacking Agents in High-Speed Coating Machines Effective Role of Anti-Tacking Agents in High-Speed Coating Machines Overview: High-speed coating machines are widely used in pharmaceutical manufacturing to apply coatings to tablets for various purposes such as taste masking, controlled release, and enteric protection. However, during the coating process, a significant issue that arises is…

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