Tag: Tablet manufacturing process​

Addressing Powder Bridging in Tablet Press Hoppers Effective Strategies for Addressing Powder Bridging in Tablet Press Hoppers Overview: Tablet manufacturing involves the use of various excipients and active pharmaceutical ingredients (APIs) in powder form. These powders are fed into the tablet press hoppers, where they are compressed into tablets. A common issue faced during this…

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Preventing Weight Loss in Hygroscopic Tablets During Drying Effective Strategies for Preventing Weight Loss in Hygroscopic Tablets During Drying Overview: Hygroscopic tablets, which absorb moisture from the air, present unique challenges during the drying process in tablet manufacturing. The weight loss that occurs in hygroscopic tablets during drying can affect both the quality of the…

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Ensuring Effective Coating Adhesion in Sustained Release Tablets Effective Strategies for Ensuring Coating Adhesion in Sustained Release Tablets Overview: Sustained release tablets are designed to deliver a drug at a controlled rate over an extended period. The coating used in these tablets is critical for ensuring the release of the drug according to the desired…

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Controlling Overdrying During Post-Coating Processes Effective Strategies for Controlling Overdrying During Post-Coating Processes Overview: The post-coating process is a crucial step in tablet production where tablets are dried after the application of coatings. During this process, the tablets need to be dried thoroughly to remove excess solvent and moisture from the coating, ensuring the final…

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Troubleshooting Spray Nozzle Clogging in Coating Machines Effective Strategies for Troubleshooting Spray Nozzle Clogging in Coating Machines Overview: Coating machines are crucial for the pharmaceutical manufacturing process, as they apply protective or functional coatings to tablets. A common issue that can arise during the coating process is spray nozzle clogging. This problem can result in…

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Avoiding Heat Degradation of APIs in Compression Stages Effective Strategies for Avoiding Heat Degradation of APIs in Compression Stages Overview: Active Pharmaceutical Ingredients (APIs) are sensitive to various environmental factors, and one of the most critical factors is heat. Heat degradation can significantly affect the stability, potency, and efficacy of APIs. In pharmaceutical manufacturing, especially…

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Ensuring Uniform Mixing in Direct Compression Processes Effective Strategies for Ensuring Uniform Mixing in Direct Compression Processes Overview: Direct compression is a widely used method in tablet manufacturing due to its simplicity, efficiency, and ability to preserve the integrity of sensitive active pharmaceutical ingredients (APIs). One of the critical aspects of the direct compression process…

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Challenges in Cleaning Rotary Tablet Press Machines Effective Strategies for Overcoming Challenges in Cleaning Rotary Tablet Press Machines Overview: Cleaning rotary tablet press machines is a critical part of the pharmaceutical manufacturing process. These machines are used to compress powder blends into tablets, which are then coated, packaged, and tested for quality. However, the process…

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Strategies for Minimizing Machine Vibrations During Compression Effective Strategies for Minimizing Machine Vibrations During Compression Overview: Machine vibrations during tablet compression are a common issue in pharmaceutical manufacturing that can lead to a range of production challenges, from poor tablet quality to operational inefficiencies. Compression machines play a crucial role in shaping the tablets and…

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Ensuring Consistency in Coating Thickness Across Tablet Batches Effective Strategies for Ensuring Consistency in Coating Thickness Across Tablet Batches Overview: Tablet coating is a vital step in pharmaceutical manufacturing that can significantly impact both the aesthetic quality and the functionality of tablets. Coating provides a protective layer for the active pharmaceutical ingredients (APIs), controls the…

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Managing Overlapping of Layers in Multi-Layer Tablets Effective Strategies for Managing Overlapping of Layers in Multi-Layer Tablets Overview: Multi-layer tablets are designed to provide controlled or sustained release of multiple active pharmaceutical ingredients (APIs) in a single dosage form. The layers within these tablets are intended to release their respective APIs at different rates or…

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Troubleshooting Weight Variations in Film-Coated Tablets Effective Strategies for Troubleshooting Weight Variations in Film-Coated Tablets Overview: Weight uniformity is a critical quality attribute in pharmaceutical tablet manufacturing. Film-coated tablets, which are coated with a thin polymeric layer, require precise weight control to ensure that each tablet contains the appropriate dose of active pharmaceutical ingredients (APIs)…

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