Tag: Tablet manufacturing process​

Reducing Dust Generation in Dry Powder Blending Effective Strategies for Reducing Dust Generation in Dry Powder Blending Overview: Dust generation during the dry powder blending process is a common challenge in pharmaceutical manufacturing. It can have significant negative impacts on product quality, worker safety, and environmental cleanliness. Dust particles can lead to inaccurate formulation, contamination…

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Preventing Capping in Multi-Stage Tablet Compression Effective Strategies for Preventing Capping in Multi-Stage Tablet Compression Overview: Tablet compression is a crucial step in pharmaceutical manufacturing, where granules or powders are compressed into solid dosage forms. Multi-stage tablet compression processes, which involve multiple compression stages, offer various advantages such as improving tablet uniformity and controlling the…

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Troubleshooting Pinholes in Film-Coated Tablets Effective Solutions for Troubleshooting Pinholes in Film-Coated Tablets Overview: Film coating is a critical process in tablet manufacturing, providing protection to the active pharmaceutical ingredients (APIs), enhancing the appearance of the tablet, and controlling drug release. However, one common issue that can arise during the film-coating process is the formation…

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Avoiding Edge Chipping in Oval-Shaped Tablets Effective Solutions for Preventing Edge Chipping in Oval-Shaped Tablets Overview: Oval-shaped tablets are commonly used in the pharmaceutical industry for both functional and aesthetic reasons. Their smooth, elongated shape is designed for easy swallowing, and their distinctive appearance can improve consumer acceptance. However, one of the challenges in the…

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Managing Temperature Variations During Tablet Drying Effective Solutions for Managing Temperature Variations During Tablet Drying Overview: Tablet drying is a crucial step in pharmaceutical manufacturing, ensuring that the moisture content in the tablets is within acceptable limits for stability and efficacy. However, temperature variations during the drying process can pose significant challenges. These fluctuations can…

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Real-Time Monitoring of Coating Thickness in Automated Machines Optimizing Coating Thickness Monitoring in Automated Coating Machines Overview: The coating process in tablet manufacturing is essential for providing protection, improving appearance, and controlling the release of active pharmaceutical ingredients (APIs). One of the key challenges in the coating process is ensuring that the coating thickness is…

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Preventing API Loss During High-Speed Granulation Effective Strategies for Preventing API Loss During High-Speed Granulation Overview: High-speed granulation is a widely used process in the pharmaceutical industry to improve the flowability, compressibility, and uniformity of powders used in tablet formulations. While this technique is essential for ensuring optimal tablet characteristics, it can also lead to…

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Challenges in Cleaning Coating Pans After Sugar-Coating Effective Strategies for Cleaning Coating Pans After Sugar-Coating Overview: Coating pans are essential equipment in the pharmaceutical industry used for applying coatings to tablets. After the sugar-coating process, cleaning the coating pan thoroughly becomes a critical task to ensure that cross-contamination does not occur in subsequent batches and…

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Addressing Layer Separation in Bilayer Tablets During Compression Effective Strategies for Addressing Layer Separation in Bilayer Tablets During Compression Overview: Bilayer tablets are a popular formulation in the pharmaceutical industry, offering controlled release of two different active pharmaceutical ingredients (APIs) or distinct release profiles for a single API. However, one common issue faced during the…

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Managing Coating Layer Flaking in Sugar-Coated Tablets Effective Strategies for Managing Coating Layer Flaking in Sugar-Coated Tablets Overview: Sugar-coated tablets are commonly used in the pharmaceutical industry due to their ability to mask unpleasant tastes, enhance tablet appearance, and provide a protective barrier for the active pharmaceutical ingredient (API). However, one of the common issues…

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Preventing Powder Segregation in Vibratory Feeders Effective Strategies for Preventing Powder Segregation in Vibratory Feeders Overview: In pharmaceutical tablet manufacturing, uniformity of powder mixture is crucial for achieving consistent dosage and tablet quality. Vibratory feeders are often used to transport powders into the tablet press, but one of the common challenges in this process is…

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Controlling Residual Moisture in Enteric-Coated Tablets Effective Strategies for Controlling Residual Moisture in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from stomach acid and to deliver it in the intestine where the drug is absorbed. However, one of the challenges associated with the manufacturing of enteric-coated tablets is…

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