Tag: Tablet manufacturing process​

Preventing Fines Generation in Spray Drying Processes Guidelines for Preventing Fines Generation in Spray Drying Processes Overview: Spray drying is a widely used technique in the pharmaceutical industry to convert liquid formulations, including suspensions or solutions, into fine powder form. This process involves spraying a liquid feed into a heated chamber where rapid evaporation of…

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Avoiding Granule Attrition During Fluid Bed Drying Techniques for Avoiding Granule Attrition During Fluid Bed Drying Overview: Granule attrition, or the breaking down of granules into smaller particles during processing, is a significant issue in pharmaceutical manufacturing, especially during fluid bed drying. Fluid bed drying is commonly used to remove moisture from granules after the…

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Controlling Spray Rate in Sugar-Coating for Glossy Finish Guidelines for Controlling Spray Rate in Sugar-Coating for a Glossy Finish Overview: In tablet manufacturing, sugar coating plays a crucial role in enhancing the aesthetic appeal, masking undesirable tastes, and providing stability to the active pharmaceutical ingredient (API). One of the most desired characteristics of sugar-coated tablets…

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Real-Time Adjustment of Compression Force for Uniform Hardness Techniques for Real-Time Adjustment of Compression Force for Uniform Hardness Overview: Tablet hardness is a critical parameter in pharmaceutical manufacturing, as it affects the mechanical strength, dissolution rate, and overall product integrity. One of the key factors influencing tablet hardness is the compression force applied during tablet…

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Addressing Poor Adhesion in Coated Tablets with Complex Designs Guidelines for Addressing Poor Adhesion in Coated Tablets with Complex Designs Overview: Coated tablets are widely used in pharmaceutical manufacturing to protect active pharmaceutical ingredients (APIs), improve patient compliance, and mask the taste of bitter or unpleasant drugs. However, tablets with complex designs—such as multi-layered, film-coated,…

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Preventing Blistering in Sugar-Coated Tablets During Drying Effective Solutions for Preventing Blistering in Sugar-Coated Tablets During Drying Overview: Sugar coating is a widely used technique in tablet manufacturing to protect active pharmaceutical ingredients (APIs) and improve the appearance and taste of the final product. However, one of the most common problems encountered during the sugar…

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Managing Static Charge in Powder Transfer During Compression Effective Strategies for Managing Static Charge in Powder Transfer During Compression Overview: Static charge build-up during the powder transfer process is a common challenge in tablet manufacturing, particularly during dry granulation or powder blending. The presence of static charge can negatively affect powder flow, leading to uneven…

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Troubleshooting Weight Variation in Tablets from Different Punches Effective Solutions for Troubleshooting Weight Variation in Tablets from Different Punches Overview: Tablet manufacturing is a highly sensitive process that requires careful control over all parameters to ensure that the final product is consistent and meets the required specifications. One of the most common issues that arise…

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Controlling Granule Size in Roller Compaction for Uniform Tablets Effective Approaches to Controlling Granule Size in Roller Compaction for Uniform Tablets Overview: Roller compaction is a widely used dry granulation technique in tablet manufacturing, particularly for powders that are sensitive to moisture. This method involves compressing powder blends between two rollers to form ribbons or…

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Managing Sticking Problems in Enteric Coating Processes Effective Solutions for Managing Sticking Problems in Enteric Coating Processes Overview: Enteric coating is a crucial part of tablet manufacturing, designed to protect active pharmaceutical ingredients (APIs) from stomach acid and ensure that the API is released in the intestine. This coating process is especially important for drugs…

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Optimizing Binder Distribution in Granulation for Uniformity Achieving Consistent Binder Distribution for Granulation Uniformity Overview: Binder distribution is a crucial factor in the granulation process of tablet manufacturing. The binder plays an essential role in holding the granules together, ensuring proper tablet integrity, and providing uniformity in drug content. However, improper binder distribution can lead…

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