Tag: Tablet manufacturing process​

Designing Bilayer Tablets for Complex Release Patterns Step-by-Step Guide: Designing Bilayer Tablets for Complex Release Patterns Overview: Bilayer tablets have emerged as an innovative solution for delivering drugs with complex release patterns. These tablets consist of two distinct layers, each designed to release the active pharmaceutical ingredient (API) at different rates or in different parts…

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Incorporating Multi-Unit Systems in Sustained Release Tablets Expert Guide: Incorporating Multi-Unit Systems in Sustained Release Tablets Overview: Multi-unit systems in sustained release (SR) tablets have gained prominence in pharmaceutical formulation due to their advantages over single-unit dosage forms. These systems consist of multiple small drug-containing units, such as pellets, mini-tablets, or granules, that allow for…

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Troubleshooting Swelling Issues in Sustained Release Tablets DIY and Step-by-Step Guide: Troubleshooting Swelling Issues in Sustained Release Tablets Overview: Swelling issues in sustained release (SR) tablets can significantly impact the drug release profile, leading to inconsistent dosing and therapeutic failure. Sustained release formulations are designed to release the active pharmaceutical ingredient (API) gradually over time,…

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Problems with Film Thickness Uniformity in Coated Tablets Troubleshooting and How-To Guide: Problems with Film Thickness Uniformity in Coated Tablets Overview: Film-coated tablets are commonly used in the pharmaceutical industry to enhance the stability, appearance, and release profile of drugs. However, achieving uniform film thickness during the coating process can be a significant challenge. Variations…

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Enhancing Bioavailability in Enteric-Coated Tablets Research & Trends: Enhancing Bioavailability in Enteric-Coated Tablets Overview: Bioavailability, the proportion of a drug that enters the systemic circulation in an active form, is a critical factor in the design of effective pharmaceutical formulations. In the case of enteric-coated tablets, bioavailability can be significantly impacted by the coating, which…

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Role of Controlled Particle Size in Tablet Compression Case Study: The Role of Controlled Particle Size in Tablet Compression Overview: Tablet compression is a critical step in tablet formulation, affecting both the physical properties and performance of the final product. One of the key factors influencing compression is the particle size of the powders used…

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Overcoming Challenges with Moisture-Sensitive APIs in Tablets Troubleshooting and How-To Guide: Overcoming Challenges with Moisture-Sensitive APIs in Tablets Overview: Moisture-sensitive active pharmaceutical ingredients (APIs) present unique challenges during tablet formulation. Exposure to moisture can lead to API degradation, altered bioavailability, and changes in the stability of the final product. This is especially critical in immediate…

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Incorporating Taste-Masking Agents in Immediate Release Tablets Expert Guide: Incorporating Taste-Masking Agents in Immediate Release Tablets Overview: For patients, particularly pediatric and geriatric populations, the taste of oral medications plays a significant role in medication adherence. Many active pharmaceutical ingredients (APIs) have a bitter or unpleasant taste that can cause reluctance to take medications. This…

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Solubility Enhancers in Sustained Release Tablet Formulations Research & Trends: The Role of Solubility Enhancers in Sustained Release Tablet Formulations Overview: Solubility is a crucial factor in the design and development of pharmaceutical formulations. Many active pharmaceutical ingredients (APIs) exhibit poor solubility, which can negatively impact the bioavailability and therapeutic efficacy of a drug. This…

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Troubleshooting Formulation Issues in High-Dose Tablets Troubleshooting Formulation Issues in High-Dose Tablets Overview: High-dose tablets present unique challenges during the formulation process due to the large amounts of active pharmaceutical ingredients (APIs) involved. These tablets require careful consideration of excipient selection, tablet manufacturing processes, and regulatory compliance. Poor formulation can lead to issues such as…

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Role of Anti-Tacking Agents in Film-Coated Tablets Understanding the Role of Anti-Tacking Agents in Film-Coated Tablets Overview: Anti-tacking agents play a crucial role in the film coating process of tablets, helping to ensure smooth and efficient production by preventing the formation of unwanted sticky surfaces. These agents are particularly useful in film-coated tablet formulations where…

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Designing Enteric-Coated Tablets for Delayed Drug Release DIY and Step-by-Step Guide to Designing Enteric-Coated Tablets for Delayed Drug Release Overview: Enteric-coated tablets are designed to prevent the release of the active pharmaceutical ingredient (API) until the tablet reaches the small intestine. This delayed release mechanism is ideal for APIs that are sensitive to stomach acid,…

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