Tag: Tablet manufacturing process​

Addressing Uniformity of Coating Weight Across Batch Sizes Step-by-Step Guide to Achieving Uniformity in Coating Weight Across Batch Sizes Overview: Uniform coating weight is critical in pharmaceutical tablet manufacturing to ensure consistent drug release, aesthetic appeal, and tablet stability. Variations in coating weight across different batch sizes can lead to dosage inconsistency, poor adhesion, and…

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Overcoming Brittleness in Tablets Containing Large API Molecules Strategies to Overcome Brittleness in Tablets Containing Large API Molecules Overview: One of the major challenges in tablet formulation is ensuring sufficient mechanical strength while maintaining desired dissolution and disintegration properties. Tablets containing large API molecules often exhibit increased brittleness due to poor compressibility, weak interparticle bonding,…

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Preventing Sticking During the Compression of Immediate Release Tablets How to Prevent Sticking Issues During the Compression of Immediate Release Tablets Overview: Sticking during tablet compression is a common problem in immediate release (IR) tablet manufacturing. It occurs when the tablet material adheres to the punch surfaces instead of forming a smooth tablet surface. This…

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Managing Particle Size Distribution in Film-Coated Tablets Effective Strategies for Managing Particle Size Distribution in Film-Coated Tablets Overview: Particle size distribution (PSD) plays a crucial role in the manufacturing and performance of film-coated tablets. Variations in particle size can affect tablet compressibility, flowability, coating uniformity, and dissolution rates. Poor PSD control may result in coating…

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Impact of Polymer Type on Delayed-Release Profiles in Enteric Tablets Understanding the Impact of Polymer Type on Delayed-Release Profiles in Enteric Tablets Overview: Enteric-coated tablets are designed to protect acid-sensitive drugs from degradation in the stomach and ensure targeted drug release in the intestine. The success of enteric formulations largely depends on the choice of…

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API Degradation in Sugar-Coated Tablet Formulations: Prevention Strategies Preventing API Degradation in Sugar-Coated Tablet Formulations Overview: Sugar coating has been a traditional approach in pharmaceutical tablet formulation, providing benefits such as taste masking, improved stability, and enhanced visual appeal. However, one of the key challenges associated with sugar-coated tablets is the risk of API (Active…

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Addressing Layer Adhesion Problems in Multi-Layer Tablets Step-by-Step Guide: Addressing Layer Adhesion Problems in Multi-Layer Tablets Overview: Multi-layer tablets are commonly used in pharmaceutical formulations to separate incompatible drugs, control release profiles, or combine multiple active pharmaceutical ingredients (APIs). However, a major challenge in their manufacturing is poor layer adhesion, which can lead to delamination,…

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Selecting the Optimal Binder for Granulation Processes Expert Guide: Selecting the Optimal Binder for Granulation Processes Overview: Granulation is a crucial step in pharmaceutical tablet manufacturing, ensuring proper powder flowability, compressibility, and uniformity. The selection of a suitable binder is critical to achieving the desired granule characteristics, as binders help in particle adhesion, mechanical strength,…

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Preventing Tablet Capping in Formulation Stages Troubleshooting and How-To Guide: Preventing Tablet Capping in Formulation Stages Overview: Tablet capping is a common issue in pharmaceutical manufacturing where the upper or lower surface of a tablet detaches or separates during ejection or handling. Capping is a serious defect that compromises tablet integrity, drug release, and patient…

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Achieving Consistency in Tablet Weight During Formulation Development Step-by-Step Guide: Ensuring Consistent Tablet Weight in Formulation Development Overview: Consistency in tablet weight is a critical factor in pharmaceutical manufacturing. Variations in tablet weight can lead to dosage inaccuracies, affecting drug efficacy and patient safety. Regulatory agencies such as the FDA and EMA have stringent guidelines…

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Role of Functional Polymers in Extended Release Tablets Research & Trends: The Role of Functional Polymers in Extended Release Tablets Overview: Extended-release (ER) tablets are designed to maintain therapeutic drug levels in the bloodstream for a prolonged period, reducing dosing frequency and improving patient compliance. A key component in these formulations is the use of…

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