Tag: Tablet manufacturing process​

Troubleshooting Non-Homogeneous Color Distribution in Coated Tablets How to Troubleshoot Non-Homogeneous Color Distribution in Coated Tablets Overview: Uniform color distribution in film-coated tablets is critical for maintaining product aesthetics, brand identity, and batch-to-batch consistency. However, pharmaceutical manufacturers often encounter non-homogeneous color distribution, which results in uneven shading, mottling, or streaking on the tablet surface. These…

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Using Advanced Analytical Techniques for Pre-Formulation Studies Expert Guide to Advanced Analytical Techniques for Pre-Formulation Studies Overview: Pre-formulation studies play a vital role in pharmaceutical development by assessing the physicochemical properties of drug candidates before formulation. Understanding factors such as solubility, stability, polymorphism, and compatibility ensures the selection of the most suitable formulation approach. The…

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Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Understanding the Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Overview: The use of hydrophilic polymers in sustained-release (SR) tablet formulations has revolutionized drug delivery by enabling controlled drug release, improved patient compliance, and enhanced bioavailability. These polymers play a crucial role in modulating drug…

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Addressing Low Compressibility of Certain APIs in Tablet Formulations Expert Guide to Overcoming Low Compressibility of Certain APIs in Tablet Formulations Overview: Compressibility is a critical factor in tablet manufacturing, as it determines the ability of a powder blend to form a mechanically strong tablet under compression. Many active pharmaceutical ingredients (APIs) exhibit low compressibility…

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Managing Solvent Residues in Film-Coated Tablet Processes Step-by-Step Guide to Managing Solvent Residues in Film-Coated Tablet Processes Overview: Solvent-based film coating is widely used in pharmaceutical manufacturing to provide tablet protection, controlled drug release, and improved stability. However, residual solvents left behind after the coating process can pose significant concerns, including toxicity, regulatory non-compliance, altered…

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Troubleshooting Grittiness in Sugar-Coated Tablets How to Troubleshoot Grittiness in Sugar-Coated Tablets Overview: Sugar-coating is a widely used technique in pharmaceutical tablet manufacturing to improve appearance, mask taste, and enhance stability. However, a common issue faced during sugar coating is the occurrence of grittiness, which results in a rough or uneven surface. This defect can…

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Challenges in Combining Immediate and Sustained Release Profiles in One Tablet Expert Guide to Overcoming Challenges in Combining Immediate and Sustained Release Profiles in One Tablet Overview: Developing a dual-release tablet that combines both immediate release (IR) and sustained release (SR) drug profiles presents several formulation and manufacturing challenges. These dosage forms are designed to…

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Optimizing Disintegration Time for Immediate Release Tablets Step-by-Step Guide to Optimizing Disintegration Time for Immediate Release Tablets Overview: Immediate release (IR) tablets are designed to disintegrate rapidly in the gastrointestinal tract, ensuring fast drug absorption and onset of action. The disintegration time of an IR tablet is a critical quality attribute that directly influences dissolution,…

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Effect of Surfactants on the Dissolution Rate of Extended Release Tablets Understanding the Effect of Surfactants on the Dissolution Rate of Extended Release Tablets Overview: Surfactants play a significant role in pharmaceutical formulations, particularly in modulating the dissolution rate of extended-release (ER) tablets. In ER formulations, achieving a controlled and predictable drug release profile is…

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