Tag: Tablet manufacturing process​

Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Step-by-Step Guide to Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Overview: Enteric-coated tablets are designed to prevent drug release in the acidic environment of the stomach and ensure that the active pharmaceutical ingredient (API) reaches the small intestine for absorption. This coating is essential for drugs…

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Challenges in Multi-API Tablet Formulations for Sustained Release Exploring the Challenges and Innovations in Multi-API Tablet Formulations for Sustained Release Overview: Multi-API sustained release (SR) tablets are designed to deliver multiple active pharmaceutical ingredients (APIs) at controlled rates, improving therapeutic efficacy and patient compliance. However, developing such formulations poses significant challenges due to API incompatibility,…

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Strategies to Achieve Quick Disintegration in Immediate Release Tablets Step-by-Step Guide to Enhancing Disintegration Speed in Immediate Release Tablets Overview: Immediate release (IR) tablets must disintegrate rapidly to ensure fast drug absorption and onset of action. Delayed or incomplete disintegration can lead to poor bioavailability, reduced therapeutic effect, and regulatory non-compliance. Several factors impact tablet…

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Impact of Granule Size on Coating Uniformity in Film-Coated Tablets Expert Guide to Managing Granule Size for Improved Coating Uniformity in Film-Coated Tablets Overview: Granule size plays a crucial role in determining tablet surface texture, coating adhesion, and film uniformity. Inconsistent granule size distribution leads to coating defects such as rough surfaces, uneven polymer deposition,…

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Addressing Tablet Adhesion in Coating Pans Step-by-Step Guide to Preventing Tablet Adhesion in Coating Pans Overview: Tablet adhesion in coating pans is a common issue that can lead to poor coating uniformity, film defects, and production inefficiencies. This problem arises due to factors such as improper coating formulation, excessive spray rate, inadequate drying, and suboptimal…

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Troubleshooting Dissolution Failures in Formulated Tablets How to Troubleshoot and Fix Dissolution Failures in Tablet Formulations Overview: Dissolution failures in pharmaceutical tablet formulations can compromise drug bioavailability, regulatory compliance, and therapeutic efficacy. The failure to meet dissolution criteria may arise due to issues related to API properties, formulation composition, coating defects, or manufacturing processes. This…

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Managing Low-Flow Properties in Direct Compression Formulations Step-by-Step Guide to Overcoming Low-Flow Properties in Direct Compression Tablet Formulations Overview: Direct compression (DC) is a preferred tablet manufacturing method due to its cost-effectiveness, fewer processing steps, and reduced risk of thermal or moisture-related drug degradation. However, many active pharmaceutical ingredients (APIs) and excipients exhibit poor flowability,…

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Designing Tablets with Resistance to Crushing for Controlled Release Expert Guide to Formulating Crush-Resistant Tablets for Controlled Drug Release Overview: Pharmaceutical tablets with controlled release properties must be designed to resist crushing and tampering to ensure proper drug delivery and prevent misuse. Many controlled-release (CR) formulations, including opioids, psychotropic medications, and high-potency drugs, are prone…

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