Tag: tablet integrity

Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing

June 2, 2025 Admin

Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing Introduction: Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the alkaline environment of the intestine. This specialized coating is crucial for the targeted delivery of certain medications, ensuring their efficacy…

Solid Dosage form, Tablets

Addressing Cracking in Film Coatings of Extended Release Tablets Under Stress

May 30, 2025 Admin

Addressing Cracking in Film Coatings of Extended Release Tablets Under Stress Addressing Cracking in Film Coatings of Extended Release Tablets Under Stress Introduction: Film coatings are a critical component in the development of extended-release tablets, playing an essential role in the control of drug release rates, protection of the drug from environmental factors, and improving…

Solid Dosage form, Tablets

Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation

May 27, 2025 Admin

Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation Introduction: In the realm of pharmaceutical manufacturing, bilayer tablets have emerged as a significant advancement, offering multiple benefits such as the ability to combine incompatible substances, controlled release profiles, and patient convenience. However, the manufacturing…

Solid Dosage form, Tablets

Addressing Brittleness in Sugar-Coated Tablets During Validation Studies

May 25, 2025 Admin

Addressing Brittleness in Sugar-Coated Tablets During Validation Studies Addressing Brittleness in Sugar-Coated Tablets During Validation Studies Introduction: Sugar-coated tablets have long been a popular choice in pharmaceutical manufacturing due to their aesthetic appeal, ease of swallowing, and ability to mask the taste of active ingredients. However, the process of sugar coating can introduce brittleness, posing…

Solid Dosage form, Tablets

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing

May 22, 2025 Admin

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Introduction: Enteric-coated tablets are an essential dosage form in the pharmaceutical industry, designed to withstand the acidic environment of the stomach and release active ingredients in the more neutral environment of the intestine. This protective mechanism not only enhances…

Solid Dosage form, Tablets

Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation

May 21, 2025 Admin

Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or release profiles in a single dose. However, as beneficial as these tablets are, they come with…

Solid Dosage form, Tablets

Troubleshooting Brittleness in Coated Tablets During Validation Testing

May 21, 2025 Admin

Troubleshooting Brittleness in Coated Tablets During Validation Testing Troubleshooting Brittleness in Coated Tablets During Validation Testing Introduction: In the pharmaceutical industry, tablets are a common and vital dosage form. They offer precise dosing, ease of administration, and stability. However, the process of coating tablets, which enhances their appearance, taste, and stability, can introduce challenges. One…

Solid Dosage form, Tablets

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing

May 19, 2025 Admin

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Introduction: In the pharmaceutical industry, multi-layer tablets have become a sophisticated option for delivering multiple active pharmaceutical ingredients (APIs) with distinct release profiles. These tablets offer numerous advantages, including improved patient compliance and efficient dosing schedules. However,…

Solid Dosage form, Tablets

Ensuring Adequate Moisture Barrier in Sugar-Coated Tablet Packaging

May 18, 2025 Admin

Ensuring Adequate Moisture Barrier in Sugar-Coated Tablet Packaging Ensuring Adequate Moisture Barrier in Sugar-Coated Tablet Packaging Introduction: Sugar-coated tablets have been a mainstay in pharmaceutical formulations for decades. Their aesthetic appeal, taste masking, and ability to protect the active pharmaceutical ingredient (API) are among their numerous advantages. However, the hygroscopic nature of sugar poses a…

Solid Dosage form, Tablets

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets

May 17, 2025 Admin

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the safety and integrity of drug products is paramount. Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestine, providing targeted…

Solid Dosage form, Tablets

Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements

May 4, 2025 Admin

Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of tablets throughout their shelf life is paramount. This is particularly critical for tablets with extended stability requirements. The compatibility between the packaging and the tablet formulation…

Solid Dosage form, Tablets

Resolving Tablet Displacement in Blister Cavities During Packaging

April 25, 2025 Admin

Resolving Tablet Displacement in Blister Cavities During Packaging Resolving Tablet Displacement in Blister Cavities During Packaging Introduction: In the pharmaceutical industry, the packaging of solid dosage forms like tablets is a critical process that ensures product integrity, stability, and patient safety. Blister packaging is one of the most common methods used to protect tablets from…

Solid Dosage form, Tablets