Tag: Tablet friability testing​

Optimizing Tablet Shape and Size for Patient Compliance and Manufacturing Efficiency Expert Strategies for Optimizing Tablet Shape and Size in Pharmaceutical Manufacturing Overview: The shape and size of pharmaceutical tablets play a crucial role in patient compliance, ease of swallowing, dose uniformity, and manufacturing efficiency. Improper tablet dimensions can lead to patient discomfort, dose variability,…

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Improving Tablet Friability Without Affecting Disintegration Step-by-Step Guide to Reducing Tablet Friability While Maintaining Rapid Disintegration Overview: Tablet friability refers to the tendency of a tablet to chip, break, or crumble during handling, packaging, and transportation. Excessive friability can compromise tablet integrity, dose uniformity, and patient compliance. However, increasing tablet hardness to reduce friability can…

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Advances in Tablet Core Design for Improved Coating Adhesion Exploring Innovations in Tablet Core Design for Enhanced Coating Adhesion Overview: The adhesion of film coatings to tablet cores is critical for maintaining product stability, protecting the API, and ensuring controlled drug release. Poor coating adhesion can lead to peeling, cracking, and reduced mechanical strength, affecting…

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Optimizing Film-Coating Parameters for Uniform Tablet Appearance Step-by-Step Guide to Optimizing Film-Coating Parameters for Uniform Tablet Appearance Overview: Achieving a uniform film coating on tablets is critical for aesthetic appeal, stability, patient compliance, and controlled drug release. Film-coating defects such as color variation, rough surfaces, cracking, peeling, and orange peel effects often arise due to…

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Preventing Cross-Contamination in Multi-Product Tablet Manufacturing Expert Strategies for Preventing Cross-Contamination in Multi-Product Tablet Manufacturing Overview: Cross-contamination in multi-product tablet manufacturing poses a significant risk to product safety, regulatory compliance, and patient health. Unintended mixing of active pharmaceutical ingredients (APIs) between batches can lead to reduced efficacy, adverse reactions, and regulatory non-compliance. Effective facility design,…

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Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Step-by-Step Guide to Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Overview: Enteric-coated tablets are designed to prevent drug release in the acidic environment of the stomach and ensure that the active pharmaceutical ingredient (API) reaches the small intestine for absorption. This coating is essential for drugs…

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Challenges in Multi-API Tablet Formulations for Sustained Release Exploring the Challenges and Innovations in Multi-API Tablet Formulations for Sustained Release Overview: Multi-API sustained release (SR) tablets are designed to deliver multiple active pharmaceutical ingredients (APIs) at controlled rates, improving therapeutic efficacy and patient compliance. However, developing such formulations poses significant challenges due to API incompatibility,…

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Strategies to Achieve Quick Disintegration in Immediate Release Tablets Step-by-Step Guide to Enhancing Disintegration Speed in Immediate Release Tablets Overview: Immediate release (IR) tablets must disintegrate rapidly to ensure fast drug absorption and onset of action. Delayed or incomplete disintegration can lead to poor bioavailability, reduced therapeutic effect, and regulatory non-compliance. Several factors impact tablet…

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Impact of Granule Size on Coating Uniformity in Film-Coated Tablets Expert Guide to Managing Granule Size for Improved Coating Uniformity in Film-Coated Tablets Overview: Granule size plays a crucial role in determining tablet surface texture, coating adhesion, and film uniformity. Inconsistent granule size distribution leads to coating defects such as rough surfaces, uneven polymer deposition,…

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Addressing Tablet Adhesion in Coating Pans Step-by-Step Guide to Preventing Tablet Adhesion in Coating Pans Overview: Tablet adhesion in coating pans is a common issue that can lead to poor coating uniformity, film defects, and production inefficiencies. This problem arises due to factors such as improper coating formulation, excessive spray rate, inadequate drying, and suboptimal…

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Troubleshooting Dissolution Failures in Formulated Tablets How to Troubleshoot and Fix Dissolution Failures in Tablet Formulations Overview: Dissolution failures in pharmaceutical tablet formulations can compromise drug bioavailability, regulatory compliance, and therapeutic efficacy. The failure to meet dissolution criteria may arise due to issues related to API properties, formulation composition, coating defects, or manufacturing processes. This…

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Managing Low-Flow Properties in Direct Compression Formulations Step-by-Step Guide to Overcoming Low-Flow Properties in Direct Compression Tablet Formulations Overview: Direct compression (DC) is a preferred tablet manufacturing method due to its cost-effectiveness, fewer processing steps, and reduced risk of thermal or moisture-related drug degradation. However, many active pharmaceutical ingredients (APIs) and excipients exhibit poor flowability,…

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