Tag: Tablet friability

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation

May 17, 2025 Admin

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Introduction: In the pharmaceutical industry, tablet formulation and manufacturing represent critical processes that significantly impact the quality, efficacy, and safety of the final product. High-dose tablets are particularly challenging to develop due to the increased risks of brittleness, which…

Solid Dosage form, Tablets

Developing Validation Protocols for Tablet Compression Processes

May 10, 2025 Admin

Developing Validation Protocols for Tablet Compression Processes Developing Validation Protocols for Tablet Compression Processes Introduction: The pharmaceutical industry is tasked with ensuring that medications are both safe and effective for consumer use. Part of this responsibility involves the validation of various processes, including the tablet compression process—a critical step in the manufacturing of solid dosage…

Solid Dosage form, Tablets

Optimizing Compression Force for Extended Release Tablet Uniformity

March 25, 2025 Admin

Optimizing Compression Force for Extended Release Tablet Uniformity Optimizing Compression Force for Extended Release Tablet Uniformity Introduction: Extended release tablets are a vital component of modern pharmaceutical therapies, designed to release their active ingredients at a predetermined rate to maintain a consistent drug concentration in the bloodstream. Ensuring the uniformity of these tablets is crucial,…

Solid Dosage form, Tablets

Managing Over-Compression in Tablets with High-Dose APIs

March 18, 2025 Admin

Managing Over-Compression in Tablets with High-Dose APIs Managing Over-Compression in Tablets with High-Dose APIs Introduction: The pharmaceutical industry is increasingly challenged with the development and manufacturing of tablets that contain high-dose Active Pharmaceutical Ingredients (APIs). While these tablets are crucial for ensuring therapeutic efficacy, they come with a unique set of challenges, particularly in terms…

Solid Dosage form, Tablets

Resolving Over-Lubrication Issues in Immediate Release Tablets

March 14, 2025 Admin

Resolving Over-Lubrication Issues in Immediate Release Tablets Resolving Over-Lubrication Issues in Immediate Release Tablets Introduction: Immediate release tablets are a mainstay in the pharmaceutical industry, offering quick onset of action and ease of administration. However, the formulation and manufacturing of these tablets present unique challenges, particularly with lubrication. Over-lubrication can compromise tablet quality, affecting disintegration…

Solid Dosage form, Tablets

Identifying Causes of Friability Failures in Sugar-Coated Tablets

March 12, 2025 Admin

Identifying Causes of Friability Failures in Sugar-Coated Tablets Identifying Causes of Friability Failures in Sugar-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the quality and integrity of solid dosage forms is of paramount importance. Tablets, especially sugar-coated ones, are widely used due to their ease of administration and patient compliance. However, the friability of these…

Solid Dosage form, Tablets

Preventing Tablet Capping During High-Speed Compression

March 11, 2025 Admin

Preventing Tablet Capping During High-Speed Compression Preventing Tablet Capping During High-Speed Compression Introduction: The pharmaceutical industry is ever-evolving, with technological advancements pushing the boundaries of speed and efficiency in drug manufacturing. Tablets, as a prevalent solid dosage form, are at the forefront of this evolution. However, with high-speed compression, challenges such as tablet capping can…

Solid Dosage form, Tablets

What are the advantages of using pre-formulated direct compression excipients?

August 22, 2023August 5, 2023 Admin

Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

Tablets

How are multi-layer tablets manufactured?

August 22, 2023August 5, 2023 Admin

Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

Tablets

What are the different tablet scoring techniques?

August 22, 2023August 5, 2023 Admin

Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…

Tablets

How are sustained-release tablets formulated?

August 21, 2023August 5, 2023 Admin

Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…

Tablets

What is the purpose of using glidants in tablet manufacturing?

August 20, 2023August 5, 2023 Admin

Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…

Tablets