Tag: Tablet formulation

How to Control Granule Hardness for Improved Tablet Compression

April 2, 2025 Admin

How to Control Granule Hardness for Improved Tablet Compression How to Control Granule Hardness for Improved Tablet Compression Why is Granule Hardness Important for Tablet Compression? Granule hardness refers to the strength and cohesion of granules produced during the granulation process. Proper granule hardness is essential for achieving uniform compression, optimal tablet hardness, and consistent…

Tablets

Managing Granule Segregation During Drying and Milling

April 1, 2025 Admin

Managing Granule Segregation During Drying and Milling How to Manage Granule Segregation During Drying and Milling What is Granule Segregation? Granule segregation refers to the separation of particles or granules based on size, density, or composition during processing steps such as drying and milling. Segregation can result in inconsistent granule properties, poor flowability, uneven drug…

Tablets

Troubleshooting Poor Adhesion in Enteric-Coated Tablets During Production

April 1, 2025 Admin

Troubleshooting Poor Adhesion in Enteric-Coated Tablets During Production Troubleshooting Poor Adhesion in Enteric-Coated Tablets During Production Introduction: The production of enteric-coated tablets is a critical process in the pharmaceutical industry, ensuring the delivery of medication to the desired part of the gastrointestinal tract without degradation in the stomach. Enteric coatings protect the active pharmaceutical ingredient…

Solid Dosage form, Tablets

How to Prevent Over-Agglomeration in Fluidized Bed Granulators

April 1, 2025 Admin

How to Prevent Over-Agglomeration in Fluidized Bed Granulators How to Prevent Over-Agglomeration in Fluidized Bed Granulators What is Over-Agglomeration in Fluidized Bed Granulation? Over-agglomeration refers to the excessive clumping of particles during the granulation process in a fluidized bed granulator. This issue can lead to oversized granules, poor flow properties, uneven drug distribution, and challenges…

Tablets

Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets

March 31, 2025 Admin

Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets represent a significant advancement in drug delivery systems. They offer distinct advantages such as controlled release profiles, improved patient compliance, and the ability to combine incompatible drugs into a single…

Solid Dosage form, Tablets

Troubleshooting Adhesion Issues in Enteric-Coated Tablet Layers

March 31, 2025 Admin

Troubleshooting Adhesion Issues in Enteric-Coated Tablet Layers Troubleshooting Adhesion Issues in Enteric-Coated Tablet Layers Introduction: In the highly regulated field of pharmaceutical manufacturing, ensuring the integrity and functionality of enteric-coated tablets is crucial. These specialized coatings play a vital role in protecting active pharmaceutical ingredients (APIs) from the acidic environment of the stomach, ensuring that…

Solid Dosage form, Tablets

Troubleshooting Poor Binder Distribution in Wet Granulation

March 31, 2025 Admin

Troubleshooting Poor Binder Distribution in Wet Granulation Troubleshooting Poor Binder Distribution in Wet Granulation What is Poor Binder Distribution in Wet Granulation? Poor binder distribution occurs when the binder, used to ensure granule cohesiveness, is unevenly dispersed throughout the granulated material. This can lead to problems such as inconsistent granule size, weak granules, or excessive…

Tablets

Troubleshooting Coating Cracks During Stability Testing

March 31, 2025 Admin

Troubleshooting Coating Cracks During Stability Testing Troubleshooting Coating Cracks During Stability Testing Introduction: In the pharmaceutical industry, the stability of solid dosage forms, particularly tablets, is critical for ensuring the efficacy and safety of medication over its shelf life. Coating cracks are a prevalent issue encountered during stability testing, which can compromise the protective function…

Solid Dosage form, Tablets

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets

March 31, 2025 Admin

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Introduction: In the pharmaceutical industry, the production of film-coated tablets is a critical process that requires meticulous quality control. Thickness testing of these tablets is vital as it ensures uniformity, stability, and efficacy of the dosage form. Variability in…

Solid Dosage form, Tablets

How to Optimize Roller Compaction Parameters for Granule Uniformity

March 31, 2025 Admin

How to Optimize Roller Compaction Parameters for Granule Uniformity How to Optimize Roller Compaction Parameters for Granule Uniformity What is Roller Compaction in Granulation? Roller compaction is a dry granulation process used to produce granules by compacting powder blends between two rollers. The resulting compacted ribbons are milled to form granules of the desired size….

Tablets

Investigating Root Causes of Hardness Variability in Coated Tablets

March 31, 2025 Admin

Investigating Root Causes of Hardness Variability in Coated Tablets Investigating Root Causes of Hardness Variability in Coated Tablets Introduction: The pharmaceutical industry is committed to ensuring the quality, efficacy, and safety of its products. Among the various dosage forms, coated tablets are one of the most commonly used due to their convenience, stability, and ease…

Solid Dosage form, Tablets

Troubleshooting Failures in Stability Testing for Film-Coated Tablets

March 30, 2025 Admin

Troubleshooting Failures in Stability Testing for Film-Coated Tablets Troubleshooting Failures in Stability Testing for Film-Coated Tablets Introduction: Stability testing is a critical component in the lifecycle of any pharmaceutical product, especially for film-coated tablets. These tests ensure that the product maintains its intended efficacy, safety, and quality throughout its shelf life. Stability testing evaluates how…

Solid Dosage form, Tablets