Tag: Tablet formulation

Managing Layer Overlap in Multi-Layer Tablets During Compression

March 22, 2025 Admin

Managing Layer Overlap in Multi-Layer Tablets During Compression Managing Layer Overlap in Multi-Layer Tablets During Compression Introduction: Multi-layer tablets are an advanced pharmaceutical dosage form that allows for the combination of different active pharmaceutical ingredients (APIs) or release profiles in a single unit. This technology creates opportunities for innovative drug delivery solutions, improving patient compliance…

Solid Dosage form, Tablets

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets

March 22, 2025 Admin

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Introduction: In the pharmaceutical industry, film-coated tablets represent a significant portion of solid dosage forms due to their enhanced stability, ease of swallowing, and aesthetic attributes. The coating process is critical, as it affects the tablet’s performance and patient…

Solid Dosage form, Tablets

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets

March 22, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Introduction: In the pharmaceutical industry, extended release tablets play a crucial role in delivering medication over a prolonged period, enhancing patient compliance and therapeutic efficacy. However, one of the persistent challenges in their production is the non-adherence…

Solid Dosage form, Tablets

Preventing Coating Layer Delamination in Extended Release Tablets

March 22, 2025 Admin

Preventing Coating Layer Delamination in Extended Release Tablets Preventing Coating Layer Delamination in Extended Release Tablets Introduction: In the pharmaceutical industry, the development of extended release tablets presents a significant advancement in drug delivery systems. These tablets are engineered to release medication at a predetermined rate, thereby maintaining a consistent drug concentration for an extended…

Solid Dosage form, Tablets

Managing Incompatibilities Between API and Excipients

March 21, 2025 Admin

Managing Incompatibilities Between API and Excipients How to Manage Incompatibilities Between API and Excipients What Are API-Excipient Incompatibilities? API-excipient incompatibilities occur when the active pharmaceutical ingredient (API) interacts adversely with excipients, affecting the stability, efficacy, or safety of the final product. These interactions can lead to degradation, altered release profiles, or reduced shelf life, posing…

Tablets

How to Avoid Over-Lubrication in Tablet Blends

March 21, 2025 Admin

How to Avoid Over-Lubrication in Tablet Blends Expert Guide to Avoiding Over-Lubrication in Tablet Blends What is Over-Lubrication in Tablet Blends? Over-lubrication occurs when excessive lubricant is added or over-mixed during the blending process, resulting in undesirable effects on tablet properties. While lubricants like magnesium stearate are essential for preventing sticking and ensuring smooth ejection,…

Tablets

Controlling Agglomeration in Powder Blending for High-Speed Compression

March 21, 2025 Admin

Controlling Agglomeration in Powder Blending for High-Speed Compression Controlling Agglomeration in Powder Blending for High-Speed Compression Introduction: In the pharmaceutical industry, the process of powder blending is a critical step in the production of solid dosage forms, particularly tablets. High-speed compression demands a high level of powder homogeneity to ensure tablet consistency and efficacy. However,…

Solid Dosage form, Tablets

Root Cause Analysis for Failures in Coating Layer Adhesion Tests

March 21, 2025 Admin

Root Cause Analysis for Failures in Coating Layer Adhesion Tests Root Cause Analysis for Failures in Coating Layer Adhesion Tests Introduction: The pharmaceutical industry continually strives to optimize the quality and efficiency of its products. Among the various solid dosage forms, tablets are particularly popular due to their stability, ease of administration, and manufacturing efficiency….

Solid Dosage form, Tablets

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets

March 21, 2025 Admin

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Introduction: Enteric tablets are specially designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This targeted dissolution is critical for drugs that are sensitive to stomach acid…

Solid Dosage form, Tablets

Addressing Brittleness in High-Compression Tablets During Stability Studies

March 21, 2025 Admin

Addressing Brittleness in High-Compression Tablets During Stability Studies Addressing Brittleness in High-Compression Tablets During Stability Studies Introduction: In the pharmaceutical industry, the development and production of solid dosage forms, particularly tablets, is a critical aspect of delivering effective therapies to patients. High-compression tablets are increasingly popular due to their compact size and ease of production….

Solid Dosage form, Tablets

Troubleshooting Wet Granulation Formulation Challenges for Coated Tablets

March 20, 2025 Admin

Troubleshooting Wet Granulation Formulation Challenges for Coated Tablets FAQs on Troubleshooting Wet Granulation Formulation Challenges for Coated Tablets What Are Wet Granulation Challenges in Coated Tablet Manufacturing? Wet granulation involves the addition of a liquid binder to form granules from powdered ingredients, ensuring proper flowability, compressibility, and uniformity. However, during coated tablet production, challenges such…

Tablets

Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets

March 20, 2025 Admin

Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Introduction: Content uniformity is a critical quality attribute in the manufacturing of film-coated tablets. Ensuring that each tablet contains the appropriate amount of active pharmaceutical ingredient (API) is essential for efficacy, safety, and regulatory compliance. Content uniformity…

Solid Dosage form, Tablets