Tag: Tablet formulation

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production

March 27, 2025 Admin

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Introduction: Hygroscopic tablets are an essential component of the pharmaceutical industry, offering a convenient and effective means of delivering medication to patients. However, their production poses significant challenges due to their sensitivity to humidity. Excess moisture can…

Solid Dosage form, Tablets

Troubleshooting Tablet Sticking During Film Coating

March 26, 2025 Admin

Troubleshooting Tablet Sticking During Film Coating Troubleshooting Tablet Sticking During Film Coating What is Tablet Sticking in Film Coating? Tablet sticking occurs when coated tablets adhere to each other or to the walls of the coating pan during the film coating process. This issue compromises the quality of the coating, leading to uneven surfaces, defects,…

Tablets

Root Cause Analysis of Failures in Weight Uniformity Tests

March 26, 2025 Admin

Root Cause Analysis of Failures in Weight Uniformity Tests Root Cause Analysis of Failures in Weight Uniformity Tests Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency and quality of dosage forms is paramount. One of the critical quality control tests for solid dosage forms, specifically tablets, is the weight uniformity test. This test…

Solid Dosage form, Tablets

Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets

March 26, 2025 Admin

Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a critical component in the pharmaceutical industry, designed to deliver active ingredients to the intestines without being degraded by stomach acid. The integrity of this enteric coating is vital, and one key quality parameter is the thickness…

Solid Dosage form, Tablets

Ensuring Consistency in API Release Profiles for Controlled Release Tablets

March 26, 2025 Admin

Ensuring Consistency in API Release Profiles for Controlled Release Tablets Ensuring Consistency in API Release Profiles for Controlled Release Tablets Introduction: In the world of pharmaceuticals, controlled release tablets play a pivotal role in ensuring the therapeutic efficacy of drugs. These formulations are designed to release active pharmaceutical ingredients (APIs) at a predetermined rate, maintaining…

Solid Dosage form, Tablets

How to Optimize Spray Rate for Uniform Tablet Coating

March 26, 2025 Admin

How to Optimize Spray Rate for Uniform Tablet Coating How to Optimize Spray Rate for Uniform Tablet Coating Why is Spray Rate Important in Tablet Coating? The spray rate is a critical parameter in the tablet coating process, determining the uniformity, consistency, and quality of the coating layer. An optimized spray rate ensures that the…

Tablets

Managing Particle Size Reduction in High-Dose API Tablet Formulations

March 25, 2025 Admin

Managing Particle Size Reduction in High-Dose API Tablet Formulations Expert Guide to Managing Particle Size Reduction in High-Dose API Tablet Formulations Why is Particle Size Reduction Important in High-Dose API Formulations? Particle size reduction is a critical step in the formulation of high-dose active pharmaceutical ingredient (API) tablets. Reducing the particle size of the API…

Tablets

Troubleshooting Residual Solvent Levels in Coated Tablets

March 25, 2025 Admin

Troubleshooting Residual Solvent Levels in Coated Tablets Troubleshooting Residual Solvent Levels in Coated Tablets Introduction: Residual solvents in coated tablets are a significant concern in pharmaceutical manufacturing due to their potential impact on product safety, efficacy, and compliance with regulatory standards. These solvents, often used in the tablet coating process, must be carefully controlled to…

Solid Dosage form, Tablets

Optimizing Compression Force for Extended Release Tablet Uniformity

March 25, 2025 Admin

Optimizing Compression Force for Extended Release Tablet Uniformity Optimizing Compression Force for Extended Release Tablet Uniformity Introduction: Extended release tablets are a vital component of modern pharmaceutical therapies, designed to release their active ingredients at a predetermined rate to maintain a consistent drug concentration in the bloodstream. Ensuring the uniformity of these tablets is crucial,…

Solid Dosage form, Tablets

Identifying Root Causes of Non-Uniform Coating Thickness in Tablets

March 25, 2025 Admin

Identifying Root Causes of Non-Uniform Coating Thickness in Tablets Identifying Root Causes of Non-Uniform Coating Thickness in Tablets Introduction: In the pharmaceutical industry, the coating of tablets is a critical process that ensures not only the aesthetic appeal and patient compliance but also the protection of the active pharmaceutical ingredient (API) from environmental factors. Non-uniform…

Solid Dosage form, Tablets

How to Formulate Tablets for Osmotic Drug Delivery Systems

March 24, 2025 Admin

How to Formulate Tablets for Osmotic Drug Delivery Systems Step-by-Step Guide to Formulating Tablets for Osmotic Drug Delivery Systems What Are Osmotic Drug Delivery Systems? Osmotic drug delivery systems (ODDS) are advanced formulations designed to control the release of drugs by utilizing osmotic pressure. These systems ensure a consistent drug release rate, independent of environmental…

Tablets

Troubleshooting Dissolution Failures in Enteric-Coated Tablets

March 24, 2025 Admin

Troubleshooting Dissolution Failures in Enteric-Coated Tablets Troubleshooting Dissolution Failures in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to bypass the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This coating is crucial for drugs that can be degraded by stomach acid or can…

Solid Dosage form, Tablets