Tag: tablet dissolution

Managing Calibration Failures in Dissolution Testing Equipment for Coated Tablets

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Managing Calibration Failures in Dissolution Testing Equipment for Coated Tablets Managing Calibration Failures in Dissolution Testing Equipment for Coated Tablets Introduction: Dissolution testing is a critical quality control measure in the pharmaceutical industry, especially for coated tablets. It ensures that the drug releases its active ingredients at the intended rate and extent. However, calibration failures…

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Managing API Migration in Multi-API Tablets During Stability Testing

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Managing API Migration in Multi-API Tablets During Stability Testing Managing API Migration in Multi-API Tablets During Stability Testing Introduction: In the ever-evolving world of pharmaceuticals, the development of multi-active pharmaceutical ingredient (API) tablets has gained significant momentum. These formulations offer the advantage of delivering multiple therapeutic effects in a single dose, enhancing patient compliance and…

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Ensuring Robustness in QA Monitoring for Immediate Release Tablets

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Ensuring Robustness in QA Monitoring for Immediate Release Tablets Ensuring Robustness in QA Monitoring for Immediate Release Tablets Introduction: Quality Assurance (QA) in the pharmaceutical industry is a critical component that ensures the safety, efficacy, and quality of medicinal products. For immediate release tablets, which are designed to disintegrate and release their active pharmaceutical ingredients…

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Solid Dosage form, Tablets

Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time

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Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their ability to mask unpleasant tastes and improve patient compliance. However, maintaining the potency of the Active Pharmaceutical Ingredient (API)…

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Solid Dosage form, Tablets

Ensuring Consistency in API Release Profiles for Controlled Release Tablets

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Ensuring Consistency in API Release Profiles for Controlled Release Tablets Ensuring Consistency in API Release Profiles for Controlled Release Tablets Introduction: In the world of pharmaceuticals, controlled release tablets play a pivotal role in ensuring the therapeutic efficacy of drugs. These formulations are designed to release active pharmaceutical ingredients (APIs) at a predetermined rate, maintaining…

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Solid Dosage form, Tablets

Addressing Challenges in Process Validation for Immediate Release Tablets

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Addressing Challenges in Process Validation for Immediate Release Tablets Addressing Challenges in Process Validation for Immediate Release Tablets Introduction: Immediate release tablets are a cornerstone in the pharmaceutical industry, known for their rapid disintegration and absorption properties, providing swift therapeutic effects. As the demand for these tablets continues to grow, ensuring their efficacy and safety…

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Solid Dosage form, Tablets

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets

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Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Introduction: In the pharmaceutical industry, film-coated tablets represent a significant portion of solid dosage forms due to their enhanced stability, ease of swallowing, and aesthetic attributes. The coating process is critical, as it affects the tablet’s performance and patient…

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Solid Dosage form, Tablets

Identifying Root Causes of Poor Disintegration in Film-Coated Tablets

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Identifying Root Causes of Poor Disintegration in Film-Coated Tablets Identifying Root Causes of Poor Disintegration in Film-Coated Tablets Introduction: Film-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their enhanced stability, ease of ingestion, and ability to mask unpleasant tastes. However, one critical quality attribute for these tablets is their…

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Solid Dosage form, Tablets

Managing Tablet Core Erosion in Enteric-Coated Tablets

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Managing Tablet Core Erosion in Enteric-Coated Tablets Managing Tablet Core Erosion in Enteric-Coated Tablets Introduction: Enteric-coated tablets represent a sophisticated drug delivery system designed to bypass the acidic environment of the stomach and to release their active ingredients in the more neutral pH of the intestines. This method of delivery is essential for drugs that…

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Solid Dosage form, Tablets

Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets

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Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Introduction: Content uniformity is a critical quality attribute in the manufacturing of film-coated tablets. Ensuring that each tablet contains the appropriate amount of active pharmaceutical ingredient (API) is essential for efficacy, safety, and regulatory compliance. Content uniformity…

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Identifying Causes of Tablet Swelling During Disintegration Testing

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Identifying Causes of Tablet Swelling During Disintegration Testing Identifying Causes of Tablet Swelling During Disintegration Testing Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms, such as tablets, is paramount. A critical aspect of this quality control is disintegration testing, a process that evaluates how quickly a tablet breaks down…

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Solid Dosage form, Tablets

Resolving Over-Lubrication Issues in Immediate Release Tablets

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Resolving Over-Lubrication Issues in Immediate Release Tablets Resolving Over-Lubrication Issues in Immediate Release Tablets Introduction: Immediate release tablets are a mainstay in the pharmaceutical industry, offering quick onset of action and ease of administration. However, the formulation and manufacturing of these tablets present unique challenges, particularly with lubrication. Over-lubrication can compromise tablet quality, affecting disintegration…

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Solid Dosage form, Tablets