Tag: tablet disintegration

Managing Failures in Stress Testing for Controlled Release Tablets

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Managing Failures in Stress Testing for Controlled Release Tablets Managing Failures in Stress Testing for Controlled Release Tablets Introduction: In the pharmaceutical industry, controlled release tablets play a pivotal role in ensuring the precise delivery of active pharmaceutical ingredients (APIs) over an extended period. These tablets are designed to optimize therapeutic efficacy and improve patient…

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Solid Dosage form, Tablets

Resolving Coating Integrity Issues in Enteric-Coated Tablets

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Resolving Coating Integrity Issues in Enteric-Coated Tablets Resolving Coating Integrity Issues in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a critical component of modern pharmaceutical formulations. These specialized coatings are designed to withstand the acidic environment of the stomach, ensuring that the active pharmaceutical ingredient (API) is released in the more neutral pH of the small…

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Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

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Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

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Solid Dosage form, Tablets

Common Dissolution Failures in Immediate Release Tablets

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Common Dissolution Failures in Immediate Release Tablets Common Dissolution Failures in Immediate Release Tablets Introduction: Immediate release tablets are a cornerstone of oral pharmaceutical dosage forms, designed to disintegrate and release their active ingredients promptly upon ingestion. The dissolution process plays a critical role in ensuring the therapeutic efficacy and bioavailability of these tablets. However,…

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Solid Dosage form, Tablets

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

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Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

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Solid Dosage form, Tablets

Ensuring Robustness in Disintegration Tests for High-Dose Tablets

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Ensuring Robustness in Disintegration Tests for High-Dose Tablets Ensuring Robustness in Disintegration Tests for High-Dose Tablets Introduction: In the pharmaceutical industry, high-dose tablets serve as a critical vehicle for delivering therapeutic agents effectively. Disintegration tests are essential for ensuring that these tablets dissolve appropriately, releasing their active ingredients for absorption. For high-dose tablets, achieving reliable…

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Solid Dosage form, Tablets