Tag: Tablet defects

How is tablet hardness measured using different techniques?

August 5, 2023July 31, 2023 Admin

Measurement of Tablet Hardness Using Different Techniques Tablet hardness, also known as tablet crushing strength, is an essential parameter that measures the mechanical strength and integrity of a tablet. It is an important quality control parameter in tablet manufacturing. Several techniques are available to measure tablet hardness. Here are some commonly used methods: 1. Manual…

Tablets

Explain the role of binders in tablet formulation.

August 4, 2023July 31, 2023 Admin

Role of Binders in Tablet Formulation Binders are essential excipients used in tablet formulation to impart cohesiveness to the powders in the tablet blend. They play a crucial role in ensuring that the tablet maintains its shape and integrity during and after compression. Binders are necessary because many active pharmaceutical ingredients (APIs) and other excipients…

Tablets

How are effervescent tablets produced, and what are their advantages?

August 3, 2023July 31, 2023 Admin

Production of Effervescent Tablets and Their Advantages Production of Effervescent Tablets Effervescent tablets are a unique dosage form that rapidly dissolves in water, producing a pleasant effervescence (fizzing) due to the release of carbon dioxide. The production of effervescent tablets involves specific formulation and manufacturing techniques. Here’s an overview of the production process: Formulation The…

Tablets

What are the challenges in manufacturing sublingual tablets?

August 2, 2023July 31, 2023 Admin

Challenges in Manufacturing Sublingual Tablets Sublingual tablets are a specialized type of oral dosage form that is designed to be placed under the tongue, where the drug is rapidly absorbed into the bloodstream through the sublingual mucosa. While sublingual tablets offer several advantages, such as faster onset of action and avoidance of first-pass metabolism, their…

Tablets

How do you ensure content uniformity in tablet production?

August 1, 2023July 31, 2023 Admin

Ensuring Content Uniformity in Tablet Production Content uniformity is a critical quality parameter in tablet production, ensuring that each tablet within a batch contains the correct and uniform amount of active pharmaceutical ingredient (API). Deviations in content uniformity can lead to dosing inaccuracies and affect the safety and efficacy of the medication. Here are the…

Tablets

What are the steps involved in tablet compression?

July 30, 2023August 1, 2023 Admin

Steps Involved in Tablet Compression Tablet compression is a crucial step in the manufacturing process of solid oral dosage forms. It involves transforming a blend of active pharmaceutical ingredient (API) and excipients into a compact tablet form using a tablet press. Here are the key steps involved in tablet compression: 1. Pre-Compression Stage Material Preparation:…

Tablets

Compare the Disintegration and Dissolution test

July 28, 2023July 28, 2023 Admin

Comparison of Disintegration Test and Dissolution Test Aspect Disintegration Test Dissolution Test Purpose To assess how quickly a tablet breaks apart into small particles when exposed to a fluid environment, simulating the conditions in the human body. To determine the rate at which the drug is released from the tablet and becomes available for absorption…

Tablets

What is dissolution test in tablet formulation?

July 28, 2023 Admin

Dissolution Test in Tablet Formulation The dissolution test is a critical quality control test conducted during tablet formulation to assess the rate at which a tablet’s active pharmaceutical ingredient (API) dissolves and becomes available for absorption in a specified fluid environment. This test provides valuable information about the drug’s release characteristics from the tablet and…

Tablets

What is disintegration test in tablet formulation?

July 28, 2023 Admin

Disintegration Test in Tablet Formulation The disintegration test is a crucial quality control test conducted during tablet formulation to assess how quickly a tablet disintegrates into small particles when exposed to a specified fluid environment. The disintegration time is an essential parameter that influences drug release and absorption rates. This test ensures that the tablet…

Tablets

How is a tablet’s hardness determined?

July 28, 2023 Admin

Determination of Tablet Hardness Tablet hardness, also known as tablet crushing strength, is a critical quality attribute that determines the tablet’s ability to withstand mechanical stress during handling, packaging, and transportation. The hardness of a tablet directly influences its disintegration and dissolution properties, as well as patient compliance. Various methods are used to determine tablet…

Tablets

What are the advantages of dry granulation over wet granulation?

July 28, 2023 Admin

Advantages of Dry Granulation Over Wet Granulation Advantages Dry Granulation Wet Granulation Drug Stability Dry granulation is suitable for moisture-sensitive drugs as it avoids exposure to water or solvents, preserving drug stability. Wet granulation may cause degradation of moisture-sensitive drugs due to exposure to water or solvents. Process Efficiency Dry granulation requires fewer equipment and…

Tablets

Explain the process of dry granulation in tablet manufacturing

July 28, 2023 Admin

Dry Granulation in Tablet Manufacturing Dry granulation, also known as pre-compression or slugging, is a tablet manufacturing process that involves compacting the powder blend without using any liquid binder. This method is suitable for drugs that are sensitive to moisture or heat and cannot undergo wet granulation. Dry granulation is particularly advantageous when dealing with…

Tablets