Tag: Sustained release tablet development​

Dealing with Agglomeration During Wet Granulation Step-by-Step Guide to Dealing with Agglomeration During Wet Granulation Overview: Wet granulation is a key technique in pharmaceutical tablet manufacturing, where powders are agglomerated to improve the flowability, compressibility, and homogeneity of the blend. However, a common issue faced during this process is agglomeration, which refers to the unwanted…

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Managing Humidity in Compression Areas of Hygroscopic Tablets Step-by-Step Guide to Managing Humidity in Compression Areas of Hygroscopic Tablets Overview: Hygroscopic tablets are particularly sensitive to moisture in the environment, as they tend to absorb water from the air. This moisture absorption can lead to changes in the tablet’s properties, such as increased weight variation,…

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Overcoming Heat Build-Up in Sustained Release Tablet Granulation Step-by-Step Guide to Overcoming Heat Build-Up in Sustained Release Tablet Granulation Overview: Granulation is a crucial step in the manufacturing of sustained release tablets, where powders are bound together to form granules that are then compressed into tablets. During this process, heat build-up is a common issue,…

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Resolving Flowability Issues in Tablet Press Feed Frames Step-by-Step Guide to Resolving Flowability Issues in Tablet Press Feed Frames Overview: Flowability is a crucial property in tablet manufacturing, especially in the context of tablet press feed frames. The feed frame of a tablet press holds the powder blend and delivers it to the die cavity…

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Real-Time Monitoring in Roller Compaction for Granules Step-by-Step Guide to Real-Time Monitoring in Roller Compaction for Granules Overview: Roller compaction is an essential dry granulation technique used in pharmaceutical manufacturing to improve the flow and compressibility of powders, making it easier to form tablets. However, controlling the process in real time is critical to ensure…

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Prevention of Picking and Sticking in Enteric-Coated Tablets Step-by-Step Guide to Preventing Picking and Sticking in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from stomach acids and ensure that the drug is released in the intestines. However, during the coating process, common issues such as picking and sticking…

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Maintaining Blend Homogeneity in Direct Compression Tablets Step-by-Step Guide to Maintaining Blend Homogeneity in Direct Compression Tablets Overview: Blend homogeneity is critical in pharmaceutical tablet manufacturing, especially when producing tablets using direct compression techniques. Direct compression involves compressing a powder blend into tablets without the need for a wet granulation step, which simplifies the process…

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Strategies for Reducing API Loss During Granulation Step-by-Step Guide to Reducing API Loss During Granulation Overview: Granulation is a critical process in pharmaceutical tablet manufacturing that involves the binding of active pharmaceutical ingredients (APIs) and excipients into a cohesive mass. However, a common challenge during this process is the loss of API, which can occur…

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Challenges in Uniform Distribution of Colorants in Coated Tablets Step-by-Step Guide to Overcoming Challenges in Uniform Distribution of Colorants in Coated Tablets Overview: Uniform distribution of colorants in coated tablets is a critical aspect of pharmaceutical tablet production. Colorants are used not only for aesthetic purposes but also for product identification, branding, and quality control….

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Managing Over-Compression in Slow Release Tablets Step-by-Step Guide to Managing Over-Compression in Slow Release Tablets Overview: Over-compression is a common issue in tablet manufacturing, particularly when producing slow release or controlled-release tablets. While compression is necessary to form tablets with consistent weight, size, and hardness, excessive force during the compression stage can lead to tablet…

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Role of Automation in High-Speed Granulation Processes Step-by-Step Guide to the Role of Automation in High-Speed Granulation Processes Overview: High-speed granulation is a vital process in the pharmaceutical manufacturing industry, used to produce uniform granules that are essential for tablet compression. Traditionally, granulation has been a labor-intensive process with significant variability due to human intervention….

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Preventing Dusting in Powder Handling During Compression Step-by-Step Guide to Preventing Dusting in Powder Handling During Compression Overview: Dusting is a significant issue in pharmaceutical manufacturing, especially during the powder handling and compression stages. Dust particles can lead to product loss, contamination, and safety hazards in the production environment. Moreover, dusting can cause inefficiencies in…

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