Tag: Sustained release tablet development​

Achieving Uniform Coating on Irregularly Shaped Tablets Step-by-Step Guide to Achieving Uniform Coating on Irregularly Shaped Tablets Overview: Tablet coating plays a critical role in pharmaceutical manufacturing by enhancing stability, patient compliance, taste masking, and drug release control. However, achieving uniform coating on irregularly shaped tablets presents significant challenges due to uneven surface geometry, variable…

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Addressing Instability in APIs Prone to Oxidation in Tablet Formulations Expert Guide to Preventing API Oxidation in Tablet Formulations Overview: Active Pharmaceutical Ingredients (APIs) prone to oxidation pose a significant challenge in tablet formulation, leading to reduced potency, discoloration, and degradation. Oxidation can be triggered by exposure to oxygen, light, humidity, and excipient interactions. Ensuring…

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Role of Nanoformulations in Immediate Release Tablet Development Exploring the Role of Nanoformulations in Immediate Release Tablet Development Overview: Immediate release (IR) tablets are designed for rapid drug disintegration and absorption to ensure quick therapeutic action. However, many active pharmaceutical ingredients (APIs) exhibit poor solubility and bioavailability, limiting their effectiveness in IR formulations. Nanoformulation technologies,…

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Troubleshooting the Use of High-Shear Mixers in Wet Granulation How to Troubleshoot Issues with High-Shear Mixers in Wet Granulation Overview: High-shear wet granulation is a widely used technique in pharmaceutical tablet manufacturing for improving powder flowability, compressibility, and uniform drug distribution. However, improper use of high-shear mixers can lead to granule over-wetting, inconsistent particle size,…

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Issues in Incorporating APIs with Low Melting Points in Tablet Formulations Troubleshooting Low Melting Point APIs in Tablet Formulations Overview: Active Pharmaceutical Ingredients (APIs) with low melting points pose significant challenges in tablet formulation, particularly during processes such as granulation, compression, and coating. These APIs tend to soften or degrade under processing conditions, leading to…

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Formulation Challenges in Fixed-Dose Combination Tablets Step-by-Step Guide to Overcoming Formulation Challenges in Fixed-Dose Combination Tablets Overview: Fixed-dose combination (FDC) tablets offer multiple therapeutic agents in a single dosage form, improving patient compliance, synergistic efficacy, and treatment outcomes. However, developing FDC tablets presents significant formulation challenges, including API compatibility, dissolution differences, stability concerns, and uniform…

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Optimization of Coating Process Parameters for Sugar-Coated Tablets Expert Guide to Optimizing Coating Process Parameters for Sugar-Coated Tablets Overview: Sugar coating is a traditional method used in pharmaceutical manufacturing to enhance tablet appearance, mask taste, and provide a protective layer. However, achieving a uniform and defect-free sugar coating requires careful optimization of process parameters. Issues…

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Addressing Coating Layer Delamination in Enteric-Coated Tablets Step-by-Step Guide to Preventing Coating Layer Delamination in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to resist gastric acid and release the drug in the intestine, ensuring targeted drug delivery and protection from stomach irritation. However, a common issue in enteric coating is layer delamination, where the coating…

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Troubleshooting Non-Homogeneous Color Distribution in Coated Tablets How to Troubleshoot Non-Homogeneous Color Distribution in Coated Tablets Overview: Uniform color distribution in film-coated tablets is critical for maintaining product aesthetics, brand identity, and batch-to-batch consistency. However, pharmaceutical manufacturers often encounter non-homogeneous color distribution, which results in uneven shading, mottling, or streaking on the tablet surface. These…

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Using Advanced Analytical Techniques for Pre-Formulation Studies Expert Guide to Advanced Analytical Techniques for Pre-Formulation Studies Overview: Pre-formulation studies play a vital role in pharmaceutical development by assessing the physicochemical properties of drug candidates before formulation. Understanding factors such as solubility, stability, polymorphism, and compatibility ensures the selection of the most suitable formulation approach. The…

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Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Understanding the Role of Hydrophilic Polymers in Sustained Release Tablet Formulations Overview: The use of hydrophilic polymers in sustained-release (SR) tablet formulations has revolutionized drug delivery by enabling controlled drug release, improved patient compliance, and enhanced bioavailability. These polymers play a crucial role in modulating drug…

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Addressing Low Compressibility of Certain APIs in Tablet Formulations Expert Guide to Overcoming Low Compressibility of Certain APIs in Tablet Formulations Overview: Compressibility is a critical factor in tablet manufacturing, as it determines the ability of a powder blend to form a mechanically strong tablet under compression. Many active pharmaceutical ingredients (APIs) exhibit low compressibility…

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