Tag: Stability testing

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

March 22, 2025 Admin

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

Solid Dosage form, Tablets

Managing Root Cause Analysis for Failures in Stability Studies

March 22, 2025 Admin

Managing Root Cause Analysis for Failures in Stability Studies Managing Root Cause Analysis for Failures in Stability Studies Introduction: In the pharmaceutical industry, stability studies are crucial to ensuring that a drug product maintains its intended quality, safety, and efficacy throughout its shelf life. Failures in stability studies can lead to significant setbacks in drug…

Solid Dosage form, Tablets

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets

March 21, 2025 Admin

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Introduction: Enteric tablets are specially designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This targeted dissolution is critical for drugs that are sensitive to stomach acid…

Solid Dosage form, Tablets

Preventing Cracking in Coated Tablets Due to Temperature Fluctuations

March 20, 2025 Admin

Preventing Cracking in Coated Tablets Due to Temperature Fluctuations Preventing Cracking in Coated Tablets Due to Temperature Fluctuations Introduction: In the pharmaceutical industry, the integrity of coated tablets is crucial for ensuring their efficacy and stability. Coated tablets are designed to provide a protective layer that can enhance the product’s shelf life, mask unpleasant tastes,…

Solid Dosage form, Tablets

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets

March 20, 2025 Admin

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Introduction: In the pharmaceutical industry, stability studies play a crucial role in ensuring the efficacy, safety, and quality of drug products. For film-coated tablets, stability studies are essential to evaluate how the product maintains its intended physical, chemical, microbiological,…

Solid Dosage form, Tablets

Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions.

March 19, 2025 Admin

Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions. Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions. Introduction: The stability of pharmaceutical capsules is a pivotal concern for the industry, ensuring that these dosage forms maintain their efficacy and safety over the intended shelf life. With advancements in packaging technologies,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets

March 18, 2025 Admin

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Introduction: In the world of pharmaceuticals, the stability and efficacy of tablets are of utmost importance. Hygroscopic tablets, which have a tendency to absorb moisture from the environment, pose unique challenges in maintaining their integrity and functionality. Moisture sensitivity can lead…

Solid Dosage form, Tablets

Poor reproducibility in microbial stability results for capsules stored in high-humidity environments.

March 15, 2025 Admin

Poor reproducibility in microbial stability results for capsules stored in high-humidity environments. Poor Reproducibility in Microbial Stability Results for Capsules Stored in High-Humidity Environments Introduction: Microbial stability is a critical aspect of pharmaceutical product development, particularly for solid oral dosage forms like capsules. Ensuring the reliability and consistency of microbial stability results is essential to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles

March 15, 2025 Admin

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their aesthetic appeal and ability to mask the taste of active pharmaceutical ingredients (APIs). However, the stability of these tablets can be significantly challenged…

Solid Dosage form, Tablets

Troubleshooting Variability in Dissolution Profiles During Stability Studies

March 14, 2025 Admin

Troubleshooting Variability in Dissolution Profiles During Stability Studies Troubleshooting Variability in Dissolution Profiles During Stability Studies Introduction: Dissolution testing is a critical aspect of pharmaceutical development, acting as a quality control measure to ensure that tablets release their active ingredients at the intended rate and extent. During stability studies, the variability in dissolution profiles can…

Solid Dosage form, Tablets

Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage

March 14, 2025 Admin

Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage Introduction: In the pharmaceutical industry, maintaining the integrity of solid dosage forms, particularly hygroscopic tablets, is crucial. Hygroscopic tablets are designed to absorb moisture from the environment, making them particularly vulnerable to degradation if not stored properly….

Solid Dosage form, Tablets

Evaluating Impact of Packaging Materials on Tablet Stability Profiles

March 13, 2025 Admin

Evaluating Impact of Packaging Materials on Tablet Stability Profiles Evaluating Impact of Packaging Materials on Tablet Stability Profiles Introduction: In the pharmaceutical industry, the stability of tablets is paramount to ensure efficacy and safety throughout their shelf life. Packaging materials play a crucial role in protecting tablets from environmental factors such as moisture, light, oxygen,…

Solid Dosage form, Tablets