Tag: Stability testing

Difficulty in ensuring consistent capsule sealing over long-term storage.

April 5, 2025 Admin

Difficulty in ensuring consistent capsule sealing over long-term storage. Difficulty in Ensuring Consistent Capsule Sealing Over Long-Term Storage Introduction: Capsules, whether hard or soft gelatin, are a popular solid oral dosage form used in the pharmaceutical industry for their ease of use and ability to encapsulate a range of substances. However, ensuring consistent capsule sealing…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting minor shell deformities under stability conditions.

April 5, 2025 Admin

Problems with detecting minor shell deformities under stability conditions. Problems with detecting minor shell deformities under stability conditions. Introduction: In the pharmaceutical industry, the stability of solid oral dosage forms, such as capsules, is paramount to ensuring the effectiveness and safety of medications. Capsules, whether hard or soft gelatin, can be susceptible to minor shell…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in preventing capsule movement within blister cavities.

April 5, 2025 Admin

Difficulty in preventing capsule movement within blister cavities. Difficulty in Preventing Capsule Movement within Blister Cavities Introduction: In pharmaceutical packaging, blister packs have become the standard for protecting solid oral dosage forms, such as capsules. These packs offer numerous benefits, including protection from environmental factors, tamper evidence, and patient compliance. However, one persistent issue is…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate protocols for evaluating shell-to-fill interaction effects.

April 5, 2025 Admin

Inadequate protocols for evaluating shell-to-fill interaction effects. Inadequate Protocols for Evaluating Shell-to-Fill Interaction Effects in Capsules Introduction: In the pharmaceutical industry, solid oral dosage forms such as capsules are a staple due to their ease of administration and versatility. Capsules, which can be either hard or soft gelatin, serve as a vehicle to deliver active…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of analytical methods for multi-drug capsule formulations.

April 3, 2025 Admin

Poor validation of analytical methods for multi-drug capsule formulations. Poor validation of analytical methods for multi-drug capsule formulations. Introduction: In the pharmaceutical industry, the development of multi-drug capsule formulations is a sophisticated process that requires precision and accuracy. The validation of analytical methods for these formulations is crucial as it ensures the quality, efficacy, and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies

April 3, 2025 Admin

Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies Introduction: Stability studies are a crucial component of the pharmaceutical development process, ensuring that drug products maintain their intended quality, safety, and efficacy throughout their shelf life. Non-adherence to stability protocols can lead to significant issues, including…

Solid Dosage form, Tablets

Troubleshooting Coating Cracks During Stability Testing

March 31, 2025 Admin

Troubleshooting Coating Cracks During Stability Testing Troubleshooting Coating Cracks During Stability Testing Introduction: In the pharmaceutical industry, the stability of solid dosage forms, particularly tablets, is critical for ensuring the efficacy and safety of medication over its shelf life. Coating cracks are a prevalent issue encountered during stability testing, which can compromise the protective function…

Solid Dosage form, Tablets

Troubleshooting Failures in Stability Testing for Film-Coated Tablets

March 30, 2025 Admin

Troubleshooting Failures in Stability Testing for Film-Coated Tablets Troubleshooting Failures in Stability Testing for Film-Coated Tablets Introduction: Stability testing is a critical component in the lifecycle of any pharmaceutical product, especially for film-coated tablets. These tests ensure that the product maintains its intended efficacy, safety, and quality throughout its shelf life. Stability testing evaluates how…

Solid Dosage form, Tablets

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets

March 24, 2025 Admin

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to resist the acidic environment of the stomach and release active pharmaceutical ingredients (APIs) in the more neutral pH of the intestines. This controlled release profile is…

Solid Dosage form, Tablets

Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets

March 23, 2025 Admin

Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of drug products is paramount. This is particularly crucial for hygroscopic tablets that are prone to absorbing moisture, which can compromise their integrity and therapeutic effectiveness. Managing non-compliance in…

Solid Dosage form, Tablets

Poor reproducibility in weight variation data for capsules over storage periods.

March 22, 2025 Admin

Poor reproducibility in weight variation data for capsules over storage periods. Poor reproducibility in weight variation data for capsules over storage periods. Introduction: In the pharmaceutical industry, ensuring the consistency and quality of solid oral dosage forms such as capsules is critical. Capsules, whether hard or soft gelatin, are widely used due to their ease…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms