Tag: Stability testing

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures

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Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Introduction: In the pharmaceutical industry, the stability of Active Pharmaceutical Ingredients (APIs) is crucial for ensuring the efficacy and safety of medications. Film-coated tablets are a popular dosage form, offering benefits such as ease of…

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Solid Dosage form, Tablets

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing

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Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Introduction: The pharmaceutical industry constantly strives to develop effective drug delivery mechanisms, with enteric-coated tablets serving as a crucial form of solid dosage. These tablets are designed to resist the acidic environment of the stomach, releasing their active ingredients…

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Solid Dosage form, Tablets

Addressing Deviations in Stability Studies for Bilayer Tablets

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Addressing Deviations in Stability Studies for Bilayer Tablets Addressing Deviations in Stability Studies for Bilayer Tablets Introduction: Bilayer tablets have emerged as a versatile drug delivery system, offering the advantage of combining two different drugs or formulations with varied release profiles in a single dosage form. This innovation not only improves patient compliance but also…

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Solid Dosage form, Tablets

Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions

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Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Introduction: Sugar-coated tablets have long been a staple in pharmaceutical formulations, offering benefits such as masking unpleasant tastes, improving tablet appearance, and protecting active pharmaceutical ingredients (APIs) from environmental factors. However, they also present unique challenges, particularly…

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Solid Dosage form, Tablets

Challenges in assessing the stability of capsules containing biological APIs.

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Challenges in assessing the stability of capsules containing biological APIs. Challenges in assessing the stability of capsules containing biological APIs. Introduction: The pharmaceutical industry is increasingly focusing on the development of capsules containing biological Active Pharmaceutical Ingredients (APIs) due to their potential in treating various complex diseases. However, ensuring the stability of these capsules poses…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Investigating Impact of Oxidative Stress on Coated Tablet Stability

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Investigating Impact of Oxidative Stress on Coated Tablet Stability Investigating Impact of Oxidative Stress on Coated Tablet Stability Introduction: In the pharmaceutical industry, the stability of coated tablets is a critical factor in ensuring drug efficacy and safety over their shelf life. Coated tablets are designed to protect the active pharmaceutical ingredients (APIs) from environmental…

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Solid Dosage form, Tablets

Difficulty in evaluating stability of capsules with high oil content.

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Difficulty in evaluating stability of capsules with high oil content. Difficulty in Evaluating Stability of Capsules with High Oil Content Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form, prized for their ease of use and ability to encapsulate both solid and liquid forms. However, when it comes to capsules with…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule integrity under stressed storage conditions.

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Poor validation of capsule integrity under stressed storage conditions. Poor validation of capsule integrity under stressed storage conditions. Introduction: In the pharmaceutical industry, the integrity of capsules, whether hard or soft gelatin, is paramount to ensure their efficacy, safety, and quality. Capsules are a popular solid oral dosage form due to their ease of use…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule integrity for long-term storage conditions.

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Difficulty in validating capsule integrity for long-term storage conditions. Difficulty in validating capsule integrity for long-term storage conditions. Introduction: In the pharmaceutical industry, ensuring the integrity of capsules over their shelf life is paramount. Capsules, whether hard or soft gelatin, are a preferred dosage form due to their ease of administration and ability to encapsulate…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing

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Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Introduction: Sugar-coated tablets are a popular dosage form in the pharmaceutical industry, valued for their aesthetic appeal and ability to mask unpleasant tastes. However, these advantages can be overshadowed by challenges encountered during stability testing, particularly disintegration…

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Solid Dosage form, Tablets

Difficulty in assessing the stability of capsules containing low-dose APIs.

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Difficulty in assessing the stability of capsules containing low-dose APIs. Difficulty in assessing the stability of capsules containing low-dose APIs. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount, particularly when dealing with capsules containing low-dose Active Pharmaceutical Ingredients (APIs). Stability refers to the ability of a drug product to maintain…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between laboratory and field stability data for capsules.

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Poor correlation between laboratory and field stability data for capsules. Poor correlation between laboratory and field stability data for capsules. Introduction: In the pharmaceutical industry, stability testing is a critical component that ensures the safety, efficacy, and quality of drug products throughout their shelf life. Capsules, both hard and soft gelatin, are popular solid oral…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms