Tag: Stability testing

Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions

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Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions Introduction: In the pharmaceutical industry, maintaining the integrity of solid dosage forms is crucial for ensuring efficacy and safety. Among these forms, hygroscopic tablets present unique challenges due to their affinity for moisture, which can significantly affect…

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Solid Dosage form, Tablets

Investigating Solvent Evaporation Effects on Coated Tablets During Storage

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Investigating Solvent Evaporation Effects on Coated Tablets During Storage Investigating Solvent Evaporation Effects on Coated Tablets During Storage Introduction: In the pharmaceutical industry, the stability and integrity of coated tablets during storage are paramount to ensuring their efficacy and safety. Solvent evaporation is a critical factor that can affect the coating’s performance, leading to potential…

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Solid Dosage form, Tablets

Troubleshooting Failures in Acid Resistance Testing of Enteric-Coated Tablets

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Troubleshooting Failures in Acid Resistance Testing of Enteric-Coated Tablets Troubleshooting Failures in Acid Resistance Testing of Enteric-Coated Tablets Introduction: Enteric-coated tablets are a critical part of modern pharmacology, designed to protect active ingredients from the acidic environment of the stomach and ensure release in the more neutral pH of the intestine. This targeted delivery system…

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Solid Dosage form, Tablets

Managing Brittleness in High-Dose Tablets Under Stability Conditions

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Managing Brittleness in High-Dose Tablets Under Stability Conditions Managing Brittleness in High-Dose Tablets Under Stability Conditions Introduction: In the pharmaceutical industry, the development of high-dose tablets presents several challenges, particularly concerning their brittleness under stability conditions. Brittleness can compromise the efficacy, safety, and quality of the medication, which is crucial for patient health. Understanding and…

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Solid Dosage form, Tablets

Managing API Migration in Multi-API Tablets During Stability Testing

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Managing API Migration in Multi-API Tablets During Stability Testing Managing API Migration in Multi-API Tablets During Stability Testing Introduction: In the ever-evolving world of pharmaceuticals, the development of multi-active pharmaceutical ingredient (API) tablets has gained significant momentum. These formulations offer the advantage of delivering multiple therapeutic effects in a single dose, enhancing patient compliance and…

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Solid Dosage form, Tablets

Optimizing Desiccant Placement for Sustained Release Tablet Packaging

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Optimizing Desiccant Placement for Sustained Release Tablet Packaging Optimizing Desiccant Placement for Sustained Release Tablet Packaging Introduction: In the pharmaceutical industry, the integrity of drug products is paramount, particularly for sustained release tablets that require precise control over their release mechanisms. A crucial aspect of ensuring the efficacy and safety of these medications is effective…

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Solid Dosage form, Tablets

Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity

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Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Introduction: Extended release tablets are a cornerstone of modern pharmaceutical formulations, offering controlled release of active pharmaceutical ingredients (APIs) over time to improve patient compliance and therapeutic efficacy. However, when these tablets are…

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Solid Dosage form, Tablets

Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements

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Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements Ensuring Packaging Compatibility for Tablets with Extended Stability Requirements Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of tablets throughout their shelf life is paramount. This is particularly critical for tablets with extended stability requirements. The compatibility between the packaging and the tablet formulation…

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Solid Dosage form, Tablets

Managing Surface Erosion in Sugar-Coated Tablets During Stability Studies

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Managing Surface Erosion in Sugar-Coated Tablets During Stability Studies Managing Surface Erosion in Sugar-Coated Tablets During Stability Studies Introduction: In the pharmaceutical industry, sugar-coated tablets have been a popular choice for delivering active pharmaceutical ingredients (APIs) due to their aesthetic appeal, ease of swallowing, and ability to mask the taste of certain drugs. However, during…

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Solid Dosage form, Tablets

Poor reproducibility in dissolution testing results for capsules stored under stressed conditions.

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Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Introduction: Dissolution testing is a critical quality control procedure in the pharmaceutical industry, especially for solid oral dosage forms such as capsules. It ensures that the drug releases at the intended…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies

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Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Introduction: In the realm of pharmaceuticals, ensuring consistency in the disintegration time of tablets during long-term stability studies is pivotal for guaranteeing a drug’s efficacy, safety, and patient compliance. Disintegration time is a critical quality attribute that…

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Solid Dosage form, Tablets

Challenges in preventing capsule discoloration during long-term storage.

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Challenges in preventing capsule discoloration during long-term storage. Challenges in Preventing Capsule Discoloration During Long-Term Storage Introduction: In the pharmaceutical industry, maintaining the integrity and appearance of solid oral dosage forms, such as capsules, throughout their shelf life is crucial for ensuring product efficacy and patient compliance. Capsules, whether hard or soft gelatin, are susceptible…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms