Tag: solid dosage forms

Preventing Core Breakage in Multi-Layer Tablets During Compression

March 8, 2025 Admin

Preventing Core Breakage in Multi-Layer Tablets During Compression Preventing Core Breakage in Multi-Layer Tablets During Compression Introduction: In the pharmaceutical industry, the development of multi-layer tablets offers a strategic approach to deliver multiple active pharmaceutical ingredients (APIs) or to control the release profiles of medications. However, the manufacturing of these complex dosage forms presents unique…

Solid Dosage form, Tablets

Preventing Non-Uniform API Distribution in Multi-API Tablets

March 8, 2025 Admin

Preventing Non-Uniform API Distribution in Multi-API Tablets Preventing Non-Uniform API Distribution in Multi-API Tablets Introduction: In the intricate world of pharmaceutical manufacturing, ensuring the uniform distribution of Active Pharmaceutical Ingredients (APIs) within multi-API tablets is crucial. These tablets are essential for delivering multiple therapeutic effects simultaneously, often improving patient compliance. However, achieving uniform API distribution…

Solid Dosage form, Tablets

Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders.

March 8, 2025 Admin

Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders. Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders. Introduction: In the pharmaceutical industry, ensuring the cleanliness of manufacturing equipment is paramount to maintaining product quality and safety. This task becomes particularly challenging when dealing with hygroscopic powders, which are prone to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule orientation devices for automated filling lines.

March 8, 2025 Admin

Difficulty in validating capsule orientation devices for automated filling lines. Difficulty in Validating Capsule Orientation Devices for Automated Filling Lines Introduction: In the pharmaceutical industry, the production of solid oral dosage forms such as capsules plays a crucial role. Capsules, whether hard or soft gelatin, are highly favored due to their ease of administration and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Failures in Humidity Control for Compression Equipment Areas

March 8, 2025 Admin

Troubleshooting Failures in Humidity Control for Compression Equipment Areas Troubleshooting Failures in Humidity Control for Compression Equipment Areas Introduction: In the pharmaceutical industry, maintaining precise environmental control in manufacturing areas is crucial, especially in compression equipment zones used for tablet production. Humidity control is a significant aspect of this environment, as fluctuations can lead to…

Solid Dosage form, Tablets

Optimizing Layer Adhesion in Bilayer Tablet Compression

March 7, 2025 Admin

Optimizing Layer Adhesion in Bilayer Tablet Compression Optimizing Layer Adhesion in Bilayer Tablet Compression Introduction: Bilayer tablets are an innovative solution in the pharmaceutical industry, allowing for the combination of two active ingredients with distinct release profiles or chemical characteristics. This format is crucial in cases where combination therapy is necessary, providing patient convenience and…

Solid Dosage form, Tablets

Preventing Powder Sticking in Die Cavities During Compression

March 7, 2025 Admin

Preventing Powder Sticking in Die Cavities During Compression Preventing Powder Sticking in Die Cavities During Compression Introduction: In the realm of pharmaceutical manufacturing, tablet compression is a critical step that transforms powder blends into solid dosage forms. However, one common challenge faced during this process is the sticking of powder to the die cavities. This…

Solid Dosage form, Tablets

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets

March 7, 2025 Admin

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Introduction: In the pharmaceutical industry, the production of multi-API (Active Pharmaceutical Ingredient) tablets requires precise formulation and meticulous blending to ensure each tablet meets stringent quality standards. Achieving homogeneity in powder blends is crucial for ensuring that every tablet…

Solid Dosage form, Tablets

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

March 7, 2025 Admin

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

Solid Dosage form, Tablets

Ensuring Uniform Blending of APIs in Powder Mixtures

March 6, 2025 Admin

Ensuring Uniform Blending of APIs in Powder Mixtures Ensuring Uniform Blending of APIs in Powder Mixtures Introduction: In pharmaceutical manufacturing, particularly in the production of solid dosage forms like tablets, the uniform blending of Active Pharmaceutical Ingredients (APIs) in powder mixtures is critical. This process ensures that each tablet contains the intended dosage and achieves…

Solid Dosage form, Tablets

Investigating Poor API Distribution in Content Uniformity Tests

March 6, 2025 Admin

Investigating Poor API Distribution in Content Uniformity Tests Investigating Poor API Distribution in Content Uniformity Tests Introduction: The pharmaceutical industry is heavily reliant on the precision and consistency of its products. One critical aspect of ensuring drug efficacy and safety is maintaining uniformity in the active pharmaceutical ingredient (API) distribution within solid dosage forms like…

Solid Dosage form, Tablets

Addressing API Migration in Bilayer Tablets During Long-Term Testing

March 6, 2025 Admin

Addressing API Migration in Bilayer Tablets During Long-Term Testing Addressing API Migration in Bilayer Tablets During Long-Term Testing Introduction: Bilayer tablets are an innovative pharmaceutical dosage form designed to deliver two different active pharmaceutical ingredients (APIs) or to control the release of a single API over time. However, the process of ensuring the stability and…

Solid Dosage form, Tablets