Tag: Soft gelatin capsules

Development of Capsule Formulations for Pediatric Use Developing capsule formulations for pediatric use requires careful consideration of various factors to ensure the safety, efficacy, and acceptability of the medication for children. Pediatric formulations need to be age-appropriate, easy to administer, and palatable. Here’s a step-by-step guide to the development of capsule formulations for pediatric use:…

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Different Types of Capsule Filling Machines Used in the Industry Capsule filling machines are essential equipment in the pharmaceutical industry for filling empty capsules with active pharmaceutical ingredients (APIs) and other formulations. Different types of capsule filling machines are available, each designed to meet specific production requirements and capsule sizes. Here are the main types…

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Ensuring Uniformity of Fill Weight During Capsule Production Maintaining the uniformity of fill weight is a critical aspect of capsule production to ensure that each capsule contains the correct and consistent amount of the active pharmaceutical ingredient (API) or formulation. Variability in fill weight can lead to dosage inaccuracies and affect the efficacy and safety…

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Role of Lubricants in Capsule Filling Lubricants play a vital role in capsule filling processes to facilitate smooth and efficient operations. They are added to the formulation to reduce friction and prevent adhesion between the capsule content and the surfaces of the capsule filling equipment. The proper use of lubricants is essential in ensuring consistent…

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Potential Issues with Capsule Shell Disintegration Capsule shell disintegration is a critical factor in the dissolution and release of the active pharmaceutical ingredient (API) from the capsule. Disintegration issues can affect the drug’s bioavailability, therapeutic efficacy, and patient compliance. Several potential issues may arise with capsule shell disintegration, leading to problems with drug release. Here…

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Role of Excipients in Capsule Manufacturing Excipients play a vital role in capsule manufacturing as they are inactive ingredients used alongside the active pharmaceutical ingredient (API) to facilitate the formulation process, enhance drug delivery, and improve the overall performance of the capsules. Excipients serve several important functions that contribute to the quality, stability, and bioavailability…

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Formulation and Manufacturing of Sustained-Release Capsules Sustained-release capsules, also known as extended-release or controlled-release capsules, are designed to release the active pharmaceutical ingredient (API) gradually over an extended period, providing a steady and prolonged therapeutic effect. The formulation and manufacturing of sustained-release capsules require specialized techniques and excipients to achieve the desired release profile. Here’s…

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Process of Dry Powder Filling in Capsule Production Dry powder filling is a common method used in capsule production to fill capsules with powdered or granulated materials, including active pharmaceutical ingredients (APIs) and excipients. The process involves several steps to ensure accurate and uniform filling of the capsules. Here’s a detailed explanation of the dry…

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Optimizing Capsule Formulations for Better Bioavailability Achieving better bioavailability in capsule formulations is a critical goal in pharmaceutical development. Bioavailability refers to the extent and rate at which the active pharmaceutical ingredient (API) in a capsule is absorbed into the bloodstream and becomes available for therapeutic action. Several strategies can be employed to optimize capsule…

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Preparation of Enteric-Coated Capsules Enteric-coated capsules are designed to resist disintegration and dissolution in the acidic environment of the stomach. Instead, they disintegrate and release their contents in the more alkaline environment of the small intestine. The enteric coating helps protect sensitive drugs from degradation in the stomach and allows for targeted drug release. Here’s…

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Filling Process for Soft Gelatin Capsules Soft gelatin capsules (SGC) are popular dosage forms used to deliver liquid or semi-solid formulations. The filling process for soft gelatin capsules involves several steps to ensure accurate dosing and uniformity in each capsule. Below, is a typical process of filling soft gelatin capsules: 1. Gelatin Shell Preparation The…

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Types of Capsule Shells Used in Manufacturing Capsules are popular pharmaceutical dosage forms used to encapsulate and deliver medications. There are two main types of capsule shells used in manufacturing, each with its unique properties and applications. 1. Hard Gelatin Capsules Hard gelatin capsules (HGC) are the most commonly used type of capsules in the…

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