Tag: Soft gelatin capsules

Poor alignment of capsules within blister packaging.

April 3, 2025 Admin

Poor alignment of capsules within blister packaging. Poor alignment of capsules within blister packaging. Introduction: Blister packaging is a widely used method in the pharmaceutical industry for the protection and distribution of solid oral dosage forms like capsules. This packaging format not only safeguards the product from environmental factors, such as moisture and light, but…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating cleaning procedures for encapsulation equipment.

April 2, 2025 Admin

Problems with validating cleaning procedures for encapsulation equipment. Problems with validating cleaning procedures for encapsulation equipment. Introduction: In the pharmaceutical industry, maintaining the cleanliness of manufacturing equipment is critical to ensuring product quality and patient safety. Encapsulation equipment, used extensively for producing both hard and soft gelatin capsules, poses unique challenges when it comes to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent gelatin plasticizer levels during validation.

April 2, 2025 Admin

Problems with ensuring consistent gelatin plasticizer levels during validation. Problems with Ensuring Consistent Gelatin Plasticizer Levels During Validation Introduction: The pharmaceutical industry faces numerous challenges when it comes to the formulation and validation of solid oral dosage forms, particularly capsules. Among these challenges, ensuring consistent gelatin plasticizer levels is critical in maintaining the quality and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for detecting powder compaction issues during filling.

April 2, 2025 Admin

Inadequate systems for detecting powder compaction issues during filling. Inadequate systems for detecting powder compaction issues during filling. Introduction: In the pharmaceutical industry, the precision and reliability of capsule filling are paramount to ensure product efficacy and patient safety. Hard and soft gelatin capsules are popular dosage forms, offering versatility in delivering active pharmaceutical ingredients…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in vacuum sealing of capsule containers.

April 1, 2025 Admin

Poor reproducibility in vacuum sealing of capsule containers. Poor Reproducibility in Vacuum Sealing of Capsule Containers Introduction: In the pharmaceutical industry, ensuring the integrity and stability of capsule packaging is crucial. Capsules, whether hard or soft gelatin, are sensitive to environmental factors such as moisture and oxygen, which can compromise their efficacy and shelf life….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating the performance of capsule filling equipment.

April 1, 2025 Admin

Challenges in validating the performance of capsule filling equipment. Challenges in validating the performance of capsule filling equipment. Introduction: In the pharmaceutical industry, capsule filling equipment plays a crucial role in the production of solid oral dosage forms. These machines are responsible for accurately filling hard and soft gelatin capsules with the appropriate dosage of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for thermosensitive APIs.

April 1, 2025 Admin

Difficulty in validating capsule drying processes for thermosensitive APIs. Difficulty in validating capsule drying processes for thermosensitive APIs Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and efficacy of Active Pharmaceutical Ingredients (APIs) is paramount. Thermosensitive APIs, which are prone to degradation at elevated temperatures, pose unique challenges. As capsules, especially hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in achieving consistent gelatin solution spread during validation.

April 1, 2025 Admin

Challenges in achieving consistent gelatin solution spread during validation. Challenges in achieving consistent gelatin solution spread during validation Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency of gelatin solution spread during the validation phase of capsule production is critical. Gelatin, being a key component in both hard and soft capsules, plays a vital…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High variability in capsule weight due to uneven powder blending.

March 31, 2025 Admin

High variability in capsule weight due to uneven powder blending. High Variability in Capsule Weight Due to Uneven Powder Blending Introduction: In the pharmaceutical industry, ensuring consistent capsule weight is critical for maintaining drug efficacy and patient safety. High variability in capsule weight can lead to suboptimal therapeutic outcomes and regulatory non-compliance. Uneven powder blending…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for detecting air bubbles in soft gelatin capsules.

March 29, 2025 Admin

Inadequate systems for detecting air bubbles in soft gelatin capsules. Inadequate Systems for Detecting Air Bubbles in Soft Gelatin Capsules Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry due to their ease of swallowing and ability to encapsulate a wide range of active ingredients. However, ensuring the quality and integrity…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent print clarity for batch details.

March 28, 2025 Admin

Problems with maintaining consistent print clarity for batch details. Problems with Maintaining Consistent Print Clarity for Batch Details Introduction: In the pharmaceutical industry, the ability to maintain consistent print clarity for batch details on capsules is crucial. This process ensures traceability, compliance with regulatory standards, and ultimately, patient safety. The batch details printed on capsules…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms