Tag: Soft gelatin capsules

Problems with detecting minor shell deformities under stability conditions.

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Problems with detecting minor shell deformities under stability conditions. Problems with detecting minor shell deformities under stability conditions. Introduction: In the pharmaceutical industry, the stability of solid oral dosage forms, such as capsules, is paramount to ensuring the effectiveness and safety of medications. Capsules, whether hard or soft gelatin, can be susceptible to minor shell…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate protocols for evaluating shell-to-fill interaction effects.

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Inadequate protocols for evaluating shell-to-fill interaction effects. Inadequate Protocols for Evaluating Shell-to-Fill Interaction Effects in Capsules Introduction: In the pharmaceutical industry, solid oral dosage forms such as capsules are a staple due to their ease of administration and versatility. Capsules, which can be either hard or soft gelatin, serve as a vehicle to deliver active…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High downtime of packing lines due to frequent equipment breakdowns.

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High downtime of packing lines due to frequent equipment breakdowns. High Downtime of Packing Lines Due to Frequent Equipment Breakdowns Introduction: In the pharmaceutical industry, maintaining efficient and uninterrupted production lines is crucial for meeting both market demand and regulatory standards. Packing lines, especially those involved in capsule production, play a pivotal role in ensuring…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in maintaining consistent capsule appearance during validation.

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Challenges in maintaining consistent capsule appearance during validation. Challenges in maintaining consistent capsule appearance during validation. Introduction: In the pharmaceutical industry, maintaining consistent capsule appearance is crucial during the validation phase. Capsules, being one of the most preferred solid oral dosage forms, face numerous scrutiny concerning their aesthetic and functional properties. Not only do they…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate monitoring of packaging line cleanliness.

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Inadequate monitoring of packaging line cleanliness. Inadequate Monitoring of Packaging Line Cleanliness Introduction: In the pharmaceutical industry, maintaining the cleanliness of packaging lines is critical to ensuring the safety, efficacy, and quality of drug products. Packaging lines are where the final steps of product handling occur, and any lapse in cleanliness can lead to contamination,…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent capsule hardness.

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Problems with maintaining consistent capsule hardness. Problems with Maintaining Consistent Capsule Hardness Introduction: Capsules, whether hard or soft gelatin, are among the most prevalent forms of solid oral dosage forms in the pharmaceutical industry. Ensuring consistent capsule hardness is crucial as it affects the product’s stability, dissolution rate, and bioavailability. Variability in capsule hardness can…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in gelatin cross-linking data under various storage conditions.

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Poor reproducibility in gelatin cross-linking data under various storage conditions. Poor Reproducibility in Gelatin Cross-Linking Data Under Various Storage Conditions Introduction: In the pharmaceutical industry, the stability and integrity of solid oral dosage forms, particularly capsules, are paramount. Gelatin, a common excipient used in hard and soft capsules, undergoes a process known as cross-linking, which…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of analytical methods for multi-drug capsule formulations.

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Poor validation of analytical methods for multi-drug capsule formulations. Poor validation of analytical methods for multi-drug capsule formulations. Introduction: In the pharmaceutical industry, the development of multi-drug capsule formulations is a sophisticated process that requires precision and accuracy. The validation of analytical methods for these formulations is crucial as it ensures the quality, efficacy, and…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of real-time monitoring systems for capsule sealing uniformity.

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Lack of real-time monitoring systems for capsule sealing uniformity. Lack of real-time monitoring systems for capsule sealing uniformity. Introduction: In the pharmaceutical industry, ensuring the quality and integrity of solid oral dosage forms, particularly capsules, is paramount. Capsules, both hard and soft gelatin types, are a preferred delivery system for many medications due to their…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating capsule filling for powders with poor flow properties.

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Challenges in validating capsule filling for powders with poor flow properties. Challenges in Validating Capsule Filling for Powders with Poor Flow Properties Introduction: In the realm of solid oral dosage forms, capsules stand out for their versatility and patient compliance. However, ensuring consistent and accurate filling of capsules, especially when dealing with powders possessing poor…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating capsule sealing for capsules with delayed-release profiles.

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Problems with validating capsule sealing for capsules with delayed-release profiles. Problems with Validating Capsule Sealing for Capsules with Delayed-Release Profiles Introduction: In the pharmaceutical industry, the demand for delayed-release capsules has been on the rise due to their ability to deliver active ingredients at specific sites within the gastrointestinal tract. These capsules are crucial for…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in preventing capsule deformation during shrink wrapping.

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Difficulty in preventing capsule deformation during shrink wrapping. Difficulty in preventing capsule deformation during shrink wrapping. Introduction: In the pharmaceutical industry, ensuring the integrity of solid oral dosage forms such as capsules is paramount. Capsules, whether hard or soft gelatin, are popular for their ease of administration and precise dosage delivery. However, their delicate structure…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms