Tag: scale-up challenges

Inadequate validation of high-shear mixers for powder blending.

March 31, 2025 Admin

Inadequate validation of high-shear mixers for powder blending. Inadequate validation of high-shear mixers for powder blending. Introduction: The pharmaceutical industry relies heavily on high-shear mixers for the effective blending of powders, a critical step in the production of solid oral dosage forms such as capsules and tablets. High-shear mixers are valued for their ability to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Granule Attrition in Large-Scale Granulation Operations

March 7, 2025 Admin

Managing Granule Attrition in Large-Scale Granulation Operations Managing Granule Attrition in Large-Scale Granulation Operations Introduction: In the pharmaceutical industry, granulation is a critical process in the production of solid dosage forms, particularly tablets. During large-scale granulation operations, granule attrition presents significant challenges that can affect product quality, consistency, and efficiency. Managing granule attrition is essential…

Solid Dosage form, Tablets

Addressing Challenges in API Loading During Granulation

March 2, 2025 Admin

Addressing Challenges in API Loading During Granulation Addressing Challenges in API Loading During Granulation Introduction: In the pharmaceutical industry, granulation is a critical process in the production of solid dosage forms such as tablets. Ensuring uniform distribution of the Active Pharmaceutical Ingredient (API) is vital for achieving the desired therapeutic effects and ensuring patient safety….

Solid Dosage form, Tablets