Tag: Quality control

Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation

May 5, 2025 Admin

Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation Introduction: Sustained release tablets are a cornerstone in modern pharmaceutical delivery systems, designed to release their active ingredient gradually over time to maintain therapeutic levels in the bloodstream. The coating on these tablets…

Solid Dosage form, Tablets

Challenges in maintaining uniform shell transparency during production.

May 4, 2025 Admin

Challenges in maintaining uniform shell transparency during production. Challenges in Maintaining Uniform Shell Transparency During Production Introduction: The pharmaceutical industry constantly strives for high-quality standards in manufacturing, particularly when it comes to solid oral dosage forms. Capsules, especially those with gelatin shells, are preferred due to their ease of use and aesthetic appeal. However, maintaining…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Residual Detergent Issues in Cleaning Validation Studies

May 3, 2025 Admin

Addressing Residual Detergent Issues in Cleaning Validation Studies Addressing Residual Detergent Issues in Cleaning Validation Studies Introduction: In the pharmaceutical industry, cleaning validation is an essential process to ensure that equipment used in the manufacturing of drugs is properly cleaned, preventing cross-contamination and ensuring product safety and efficacy. One of the critical components of cleaning…

Solid Dosage form, Tablets

Poor reproducibility in dissolution testing results for capsules stored under stressed conditions.

May 3, 2025 Admin

Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Introduction: Dissolution testing is a critical quality control procedure in the pharmaceutical industry, especially for solid oral dosage forms such as capsules. It ensures that the drug releases at the intended…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Preventing Incorrect Barcode Printing on Tablet Packaging Materials

May 2, 2025 Admin

Preventing Incorrect Barcode Printing on Tablet Packaging Materials Preventing Incorrect Barcode Printing on Tablet Packaging Materials Introduction: In the pharmaceutical industry, accurate barcode printing on packaging is crucial for ensuring patient safety, regulatory compliance, and efficient supply chain management. Barcodes facilitate the tracking and tracing of pharmaceutical products, aiding in the prevention of counterfeit drugs…

Solid Dosage form, Tablets

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing

April 30, 2025 Admin

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Introduction: The pharmaceutical industry constantly strives to develop effective drug delivery mechanisms, with enteric-coated tablets serving as a crucial form of solid dosage. These tablets are designed to resist the acidic environment of the stomach, releasing their active ingredients…

Solid Dosage form, Tablets

High rejection rates due to improper alignment of capsule compartments.

April 30, 2025 Admin

High rejection rates due to improper alignment of capsule compartments. High Rejection Rates Due to Improper Alignment of Capsule Compartments Introduction: In the pharmaceutical industry, the production of solid oral dosage forms, particularly capsules, is a critical process that requires precision and accuracy. Capsules, whether hard or soft gelatin, are a popular choice for delivering…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage

April 30, 2025 Admin

Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Introduction: Sugar-coated tablets are a prevalent form of oral pharmaceutical dosage due to their aesthetic appeal, taste masking abilities, and protective properties. However, during storage, these tablets can sometimes develop surface roughness, which can compromise their appearance, consumer acceptance,…

Solid Dosage form, Tablets

Challenges in predicting the impact of high humidity on capsule disintegration times.

April 30, 2025 Admin

Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated methods for testing capsule coatings.

April 29, 2025 Admin

Lack of validated methods for testing capsule coatings. Lack of validated methods for testing capsule coatings. Introduction: The pharmaceutical industry relies heavily on solid oral dosage forms, particularly capsules, for drug delivery. Capsules, whether hard or soft gelatin, often require coatings to enhance stability, control release, or mask taste. However, a critical gap persists in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets

April 28, 2025 Admin

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Introduction: Coated tablets are a widely used solid dosage form in the pharmaceutical industry, offering benefits such as improved taste masking, controlled drug release, and enhanced stability. However, achieving consistent dissolution profiles is critical as it directly impacts the…

Solid Dosage form, Tablets

Challenges in validating equipment for multi-dose capsule filling operations.

April 27, 2025 Admin

Challenges in validating equipment for multi-dose capsule filling operations. Challenges in validating equipment for multi-dose capsule filling operations Introduction: In the pharmaceutical industry, ensuring the accuracy and reliability of capsule filling operations is critical to the production of safe and effective medications. Multi-dose capsule filling operations present unique challenges due to the complex nature of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms