Tag: Quality control in pharmaceuticals

Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing

June 2, 2025 Admin

Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing Addressing Challenges in Handling Enteric-Coated Tablets During Blister Packing Introduction: Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the alkaline environment of the intestine. This specialized coating is crucial for the targeted delivery of certain medications, ensuring their efficacy…

Solid Dosage form, Tablets

Addressing Non-Uniform Coating Layers in Sustained Release Tablets

March 30, 2025 Admin

Addressing Non-Uniform Coating Layers in Sustained Release Tablets Addressing Non-Uniform Coating Layers in Sustained Release Tablets Introduction: In the pharmaceutical industry, sustained release tablets play a crucial role in ensuring consistent drug delivery over an extended period. The coating of these tablets is not just a protective layer but a critical component that influences the…

Solid Dosage form, Tablets

Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets

March 20, 2025 Admin

Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Troubleshooting Failures in Content Uniformity Tests for Film-Coated Tablets Introduction: Content uniformity is a critical quality attribute in the manufacturing of film-coated tablets. Ensuring that each tablet contains the appropriate amount of active pharmaceutical ingredient (API) is essential for efficacy, safety, and regulatory compliance. Content uniformity…

Solid Dosage form, Tablets

Real-Time Monitoring of Tablet Thickness During Compression

March 18, 2025 Admin

Real-Time Monitoring of Tablet Thickness During Compression Real-Time Monitoring of Tablet Thickness During Compression Introduction: In the pharmaceutical industry, ensuring the consistent quality of tablets is paramount. Tablet thickness, a critical quality attribute, affects not only the tablet’s appearance but also its dissolution rate and overall efficacy. Real-time monitoring of tablet thickness during compression is…

Solid Dosage form, Tablets

Managing Fines Generation During Compression of Immediate Release Tablets

March 17, 2025 Admin

Managing Fines Generation During Compression of Immediate Release Tablets Managing Fines Generation During Compression of Immediate Release Tablets Introduction: In the pharmaceutical industry, the production of immediate-release tablets is a crucial process that requires meticulous attention to detail. One of the significant challenges faced during the tablet manufacturing process is the generation of fines. Fines…

Solid Dosage form, Tablets

Poor correlation between accelerated and real-time stability results.

March 12, 2025 Admin

Poor correlation between accelerated and real-time stability results. Poor correlation between accelerated and real-time stability results. Introduction: Stability testing is an essential component of the pharmaceutical development process. It ensures that a drug product maintains its intended physical, chemical, microbiological, and therapeutic properties throughout its shelf life. Accelerated stability testing and real-time stability testing are…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Compliance with Regulatory Standards for Utility Validation Reports

March 8, 2025 Admin

Ensuring Compliance with Regulatory Standards for Utility Validation Reports Ensuring Compliance with Regulatory Standards for Utility Validation Reports Introduction: In the pharmaceutical industry, utilities such as water systems, HVAC, and compressed gases are integral to manufacturing processes. Ensuring compliance with regulatory standards for utility validation reports is crucial for maintaining product safety, efficacy, and quality….

Solid Dosage form, Tablets

Addressing Residual Moisture Issues in Purified Water Systems

March 7, 2025 Admin

Addressing Residual Moisture Issues in Purified Water Systems Addressing Residual Moisture Issues in Purified Water Systems Introduction: Purified water systems play a critical role in pharmaceutical manufacturing, ensuring that the water used in production meets stringent quality and safety standards. However, residual moisture is a common challenge that can compromise the integrity of pharmaceutical products….

Solid Dosage form, Tablets

Addressing Non-Compliance in Utility Validation for Hygroscopic Tablet Production

March 5, 2025 Admin

Addressing Non-Compliance in Utility Validation for Hygroscopic Tablet Production Addressing Non-Compliance in Utility Validation for Hygroscopic Tablet Production Introduction: In the pharmaceutical industry, producing high-quality tablets that meet regulatory standards is crucial. Among various tablet forms, hygroscopic tablets present unique challenges due to their moisture sensitivity. Utility validation is a vital part of ensuring that…

Solid Dosage form, Tablets

Troubleshooting Non-Uniform Coating in Irregular Tablet Shapes

March 3, 2025 Admin

Troubleshooting Non-Uniform Coating in Irregular Tablet Shapes Troubleshooting Non-Uniform Coating in Irregular Tablet Shapes Introduction: In the intricate world of pharmaceutical manufacturing, ensuring the uniformity of tablet coatings is paramount, particularly when dealing with irregular tablet shapes. These coatings are not just for aesthetic appeal; they serve critical functions such as protecting the tablet’s core,…

Solid Dosage form, Tablets

What are the advantages of using pre-formulated direct compression excipients?

August 22, 2023August 5, 2023 Admin

Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

Tablets

How are multi-layer tablets manufactured?

August 22, 2023August 5, 2023 Admin

Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

Tablets