Tag: quality by design

Managing Layer Delamination Issues in Multi-Layer Tablets During Validation

May 12, 2025 Admin

Managing Layer Delamination Issues in Multi-Layer Tablets During Validation Managing Layer Delamination Issues in Multi-Layer Tablets During Validation Introduction: In the pharmaceutical industry, multi-layer tablets are a popular dosage form due to their ability to deliver multiple drugs or distinct release profiles in a single tablet. However, manufacturing such tablets comes with its own set…

Solid Dosage form, Tablets

Ensuring Consistency in Layer Adhesion for Multi-Layer Tablets During Validation

May 10, 2025 Admin

Ensuring Consistency in Layer Adhesion for Multi-Layer Tablets During Validation Ensuring Consistency in Layer Adhesion for Multi-Layer Tablets During Validation Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or release profiles within a single dosage form. This complexity brings forth challenges, particularly in ensuring consistency…

Solid Dosage form, Tablets

Inadequate validation of capsule disintegration profiles for multi-particulate capsules.

April 13, 2025 Admin

Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Introduction: In the pharmaceutical industry, the validation of capsule disintegration profiles is a critical aspect of ensuring drug efficacy and patient safety. This is particularly important for multi-particulate capsules, which can offer benefits such as improved bioavailability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in implementing real-time quality monitoring systems.

April 10, 2025 Admin

Difficulty in implementing real-time quality monitoring systems. Difficulty in Implementing Real-Time Quality Monitoring Systems Introduction: In the pharmaceutical industry, maintaining high standards of product quality is of paramount importance. The advent of real-time quality monitoring systems presents an opportunity to enhance product consistency and ensure compliance with stringent regulatory requirements. These systems allow for continuous…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Identifying Causes of Poor Disintegration in Controlled Release Tablets

March 27, 2025 Admin

Identifying Causes of Poor Disintegration in Controlled Release Tablets Identifying Causes of Poor Disintegration in Controlled Release Tablets Introduction: In the realm of pharmaceuticals, controlled release tablets have become a cornerstone of modern drug delivery systems. These formulations are designed to release the active pharmaceutical ingredient (API) at a predetermined rate, providing therapeutic benefits over…

Solid Dosage form, Tablets

Managing Tablet Core Erosion in Enteric-Coated Tablets

March 21, 2025 Admin

Managing Tablet Core Erosion in Enteric-Coated Tablets Managing Tablet Core Erosion in Enteric-Coated Tablets Introduction: Enteric-coated tablets represent a sophisticated drug delivery system designed to bypass the acidic environment of the stomach and to release their active ingredients in the more neutral pH of the intestines. This method of delivery is essential for drugs that…

Solid Dosage form, Tablets

Real-Time Adjustment of Granulation Parameters for Uniformity

March 9, 2025 Admin

Real-Time Adjustment of Granulation Parameters for Uniformity Real-Time Adjustment of Granulation Parameters for Uniformity Introduction: In the pharmaceutical industry, the uniformity of granulation is critical for ensuring the quality and efficacy of solid dosage forms, particularly tablets. Granulation is a pivotal step in the tablet manufacturing process, where powder particles are aggregated to form granules….

Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

March 9, 2025 Admin

Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

Solid Dosage form, Tablets

Resolving Weight Variation Failures in Bilayer Tablets

March 2, 2025 Admin

Resolving Weight Variation Failures in Bilayer Tablets Resolving Weight Variation Failures in Bilayer Tablets Introduction: In the pharmaceutical industry, bilayer tablets have emerged as a sophisticated solution for delivering multiple drugs or achieving different release profiles in a single dosage form. However, maintaining uniform weight across these tablets poses significant challenges, impacting quality and efficacy….

Solid Dosage form, Tablets