Tag: process control]

Troubleshooting Failures in Temperature Mapping for Fluid Bed Dryers

March 15, 2025 Admin

Troubleshooting Failures in Temperature Mapping for Fluid Bed Dryers Troubleshooting Failures in Temperature Mapping for Fluid Bed Dryers Introduction: In the pharmaceutical industry, the drying process is a critical step in the production of solid dosage forms such as tablets. Fluid bed dryers play a significant role in ensuring that the drying process is efficient…

Solid Dosage form, Tablets

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets

March 15, 2025 Admin

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Introduction: In the realm of pharmaceutical manufacturing, roller compaction is a critical granulation method frequently employed for the production of large-scale tablets. This process is favored for its ability to handle heat and moisture-sensitive compounds without requiring…

Solid Dosage form, Tablets

Difficulty in monitoring fill weight uniformity during high-speed production.

March 13, 2025 Admin

Difficulty in monitoring fill weight uniformity during high-speed production. Difficulty in monitoring fill weight uniformity during high-speed production. Introduction: In the pharmaceutical industry, ensuring the uniformity of fill weight in capsule production is crucial for maintaining product quality and efficacy. This becomes increasingly complex during high-speed manufacturing, where rapid production rates can introduce variability. This…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets

March 12, 2025 Admin

Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets Introduction: The pharmaceutical industry is continuously advancing, with an emphasis on improving the quality and safety of its products. One of the critical areas of focus is the formulation and manufacturing of solid dosage forms, particularly sugar-coated tablets. These tablets are…

Solid Dosage form, Tablets

Addressing Deviations in Process Validation for Sugar-Coated Tablets

March 11, 2025 Admin

Addressing Deviations in Process Validation for Sugar-Coated Tablets Addressing Deviations in Process Validation for Sugar-Coated Tablets Introduction: The pharmaceutical industry continuously strives for excellence in manufacturing practices, ensuring product quality and compliance with stringent regulations. Among various dosage forms, sugar-coated tablets remain a staple due to their ability to mask unpleasant tastes and enhance the…

Solid Dosage form, Tablets

Ensuring Effective Binder Distribution in Wet Granulation Processes

March 9, 2025 Admin

Ensuring Effective Binder Distribution in Wet Granulation Processes Ensuring Effective Binder Distribution in Wet Granulation Processes Introduction: Wet granulation is a critical process in the production of tablets, fundamentally influencing the quality and efficacy of the final pharmaceutical product. At the heart of the wet granulation process lies the challenge of ensuring effective binder distribution….

Solid Dosage form, Tablets

Managing Fines Generation in Fluid Bed Processing

March 9, 2025 Admin

Managing Fines Generation in Fluid Bed Processing Managing Fines Generation in Fluid Bed Processing Introduction: Fluid bed processing is a critical operation in pharmaceutical manufacturing, primarily utilized for drying, granulating, and coating purposes. Its efficiency and effectiveness in producing uniform and quality granules make it a preferred choice in tablet production. However, a persistent challenge…

Solid Dosage form, Tablets

Real-Time Monitoring of Spray Uniformity in Coating Processes

March 8, 2025 Admin

Real-Time Monitoring of Spray Uniformity in Coating Processes Real-Time Monitoring of Spray Uniformity in Coating Processes Introduction: In the pharmaceutical industry, the coating process of tablets is a critical step that significantly influences the quality and efficacy of the final product. Ensuring uniformity in spray coating is essential to achieve the desired therapeutic effects, protect…

Solid Dosage form, Tablets

Preventing Cracking in Bilayer Tablets During Drying Stages

March 8, 2025 Admin

Preventing Cracking in Bilayer Tablets During Drying Stages Preventing Cracking in Bilayer Tablets During Drying Stages Introduction: Bilayer tablets are an innovative and efficient way to deliver multiple drugs or different release profiles in a single dosage form. They are engineered to provide controlled release, improve patient compliance, and optimize therapeutic outcomes. However, manufacturing bilayer…

Solid Dosage form, Tablets

Challenges in maintaining proper environmental conditions in production areas.

March 7, 2025 Admin

Challenges in maintaining proper environmental conditions in production areas. Challenges in maintaining proper environmental conditions in production areas. Introduction: The pharmaceutical industry is highly regulated, with stringent requirements for maintaining optimal environmental conditions in production areas. This is particularly critical for the manufacturing of capsules, both hard and soft gelatin, where environmental control can significantly…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

March 7, 2025 Admin

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

Solid Dosage form, Tablets

Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers

March 7, 2025 Admin

Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers Introduction: Temperature mapping is a critical component in ensuring the consistent and effective operation of fluid bed dryers used in pharmaceutical manufacturing. These dryers are essential for the production of solid dosage forms, particularly tablets,…

Solid Dosage form, Tablets