Tag: Process Analytical Technology

Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation

May 20, 2025 Admin

Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation Introduction: In the pharmaceutical industry, maintaining consistent granule size during the fluid bed granulation process is crucial for ensuring the quality and efficacy of solid dosage forms like tablets. Granule size uniformity affects the flow…

Solid Dosage form, Tablets

Validating Real-Time Moisture Monitoring Systems for Wet Granulation

May 14, 2025 Admin

Validating Real-Time Moisture Monitoring Systems for Wet Granulation Validating Real-Time Moisture Monitoring Systems for Wet Granulation Introduction: Wet granulation is a crucial process in the pharmaceutical industry, particularly for the production of tablets. It involves the agglomeration of powder particles using a liquid binder, resulting in enhanced flowability and compressibility. A critical parameter in this…

Solid Dosage form, Tablets

Poor reproducibility in rinse sampling data for lipid-based formulations.

April 17, 2025 Admin

Poor reproducibility in rinse sampling data for lipid-based formulations. Poor reproducibility in rinse sampling data for lipid-based formulations. Introduction: Lipid-based formulations have gained significant attention in the pharmaceutical industry due to their ability to enhance the bioavailability of poorly water-soluble drugs. However, ensuring the cleanliness of manufacturing equipment used for these formulations poses unique challenges,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in implementing real-time quality monitoring systems.

April 10, 2025 Admin

Difficulty in implementing real-time quality monitoring systems. Difficulty in Implementing Real-Time Quality Monitoring Systems Introduction: In the pharmaceutical industry, maintaining high standards of product quality is of paramount importance. The advent of real-time quality monitoring systems presents an opportunity to enhance product consistency and ensure compliance with stringent regulatory requirements. These systems allow for continuous…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Validating Coating Thickness Consistency Across Batch Sizes

April 8, 2025 Admin

Validating Coating Thickness Consistency Across Batch Sizes Validating Coating Thickness Consistency Across Batch Sizes Introduction: The pharmaceutical industry places significant emphasis on the quality and consistency of solid dosage forms, particularly tablets. Among the various quality attributes, coating thickness is crucial, influencing not just appearance, but also the release profile, stability, and overall efficacy of…

Solid Dosage form, Tablets

Managing Failures in Weight Variation Tests for High-Speed Compression Tablets

March 28, 2025 Admin

Managing Failures in Weight Variation Tests for High-Speed Compression Tablets Managing Failures in Weight Variation Tests for High-Speed Compression Tablets Introduction: In the pharmaceutical industry, ensuring the consistency and quality of tablet formulations is paramount. Weight variation tests are critical quality control measures that ensure each tablet contains the intended amount of active pharmaceutical ingredient…

Solid Dosage form, Tablets

High variability in capsule fill weight due to equipment vibration.

March 24, 2025 Admin

High variability in capsule fill weight due to equipment vibration. High Variability in Capsule Fill Weight Due to Equipment Vibration Introduction: In the pharmaceutical industry, ensuring the uniformity of capsule fill weight is crucial for efficacy and safety. Variability in fill weight can lead to dose inconsistencies, impacting therapeutic outcomes and regulatory compliance. One often…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation

March 23, 2025 Admin

Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation Introduction: In the pharmaceutical industry, the manufacturing of solid dosage forms such as tablets often involves the process of wet granulation. This critical process ensures the homogeneity and compressibility of the drug mixture. One of the most…

Solid Dosage form, Tablets

Detecting Agglomeration in Fluid Bed Granules During Drying

March 20, 2025 Admin

Detecting Agglomeration in Fluid Bed Granules During Drying Detecting Agglomeration in Fluid Bed Granules During Drying Introduction: Fluid bed granulation is a pivotal process in the pharmaceutical industry, integral to the production of tablets. It involves the transformation of fine powders into larger, free-flowing granules by fluidizing them in a bed and binding with a…

Solid Dosage form, Tablets

Addressing Granule Segregation During Roller Compaction

March 19, 2025 Admin

Addressing Granule Segregation During Roller Compaction Addressing Granule Segregation During Roller Compaction Introduction: In the realm of pharmaceutical manufacturing, ensuring the uniformity and quality of solid dosage forms such as tablets is crucial. Roller compaction is a dry granulation process commonly used to improve the flow properties and compressibility of powders. However, one of the…

Solid Dosage form, Tablets

Real-Time Adjustment of Compression Force for Uniform Tablet Hardness

March 18, 2025 Admin

Real-Time Adjustment of Compression Force for Uniform Tablet Hardness Real-Time Adjustment of Compression Force for Uniform Tablet Hardness Introduction: In the pharmaceutical industry, ensuring the uniformity and quality of tablets is paramount. Among the various factors that influence tablet quality, the hardness of tablets is crucial as it affects not only the mechanical strength but…

Solid Dosage form, Tablets

Real-Time Monitoring of Tablet Thickness During Compression

March 18, 2025 Admin

Real-Time Monitoring of Tablet Thickness During Compression Real-Time Monitoring of Tablet Thickness During Compression Introduction: In the pharmaceutical industry, ensuring the consistent quality of tablets is paramount. Tablet thickness, a critical quality attribute, affects not only the tablet’s appearance but also its dissolution rate and overall efficacy. Real-time monitoring of tablet thickness during compression is…

Solid Dosage form, Tablets