Tag: Pharmacokinetics in Drug Discovery

Assessing Mechanical Properties of Formulations Guide to Assessing Mechanical Properties of Formulations Ensuring the Strength and Integrity of Drug Dosage Forms Assessing the mechanical properties of drug formulations is crucial for ensuring their integrity, stability, and manufacturability. Mechanical properties such as hardness, friability, and tensile strength play a significant role in determining the physical performance…

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Preparing Prototype Formulations for Testing How to Prepare Prototype Formulations for Testing Developing Initial Drug Formulations for Screening and Optimization Prototype formulations are early-stage drug formulations developed for testing and screening purposes. These formulations serve as the foundation for further optimization and refinement before clinical trials. Preparing prototype formulations is a critical step in drug…

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Selecting Polymers for Controlled Release Formulations How to Select Polymers for Controlled Release Formulations Optimizing Drug Release and Bioavailability with the Right Polymers Controlled release formulations are designed to release the active pharmaceutical ingredient (API) at a controlled rate, ensuring consistent therapeutic effects over an extended period. The selection of the right polymers is crucial…

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Moisture Sensitivity Testing of Formulations Guide to Moisture Sensitivity Testing of Formulations Protecting Drug Stability and Efficacy from Moisture-Induced Degradation Moisture sensitivity testing is an essential aspect of formulation development, particularly for drugs that are sensitive to water. Moisture can cause degradation, hydrolysis, or changes in the physical properties of drugs, potentially compromising their efficacy….

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Using Dissolution Testing in Formulation Screening Guide to Use Dissolution Testing in Formulation Screening Ensuring Drug Release and Bioavailability with Dissolution Testing Dissolution testing is a critical method used in formulation screening to evaluate how a drug is released from its dosage form (e.g., tablets, capsules). This test helps determine the drug’s solubility and the…

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Oral Delivery System Screening for Formulations How to Conduct Oral Delivery System Screening for Formulations Optimizing Drug Absorption and Bioavailability Through Oral Delivery Systems Oral drug delivery is the most commonly used route for administering therapeutic agents. However, improving the absorption and bioavailability of poorly soluble drugs can be challenging. Screening oral delivery systems is…

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Using Predictive Tools in Formulation Development How to Use Predictive Tools in Formulation Development Leveraging Computational Models for Improved Formulation Design Predictive tools in formulation development can help researchers streamline the design process by simulating various formulation parameters and predicting their effects. These tools can reduce the need for extensive trial-and-error experimentation and improve the…

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Testing Compatibility with Packaging Materials How to Test Compatibility with Packaging Materials in Formulation Development Ensuring Stability and Efficacy of Drugs Through Proper Packaging Packaging plays a critical role in maintaining the stability and efficacy of drug formulations. Compatibility between the drug product and packaging materials is essential to prevent interactions that could lead to…

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Screening Film-Coating Formulations Guide to Screening Film-Coating Formulations Ensuring Stability, Release Profile, and Aesthetic Quality of Coated Tablets Film coating is widely used in tablet formulation to improve stability, control drug release, and enhance the appearance of the tablets. Screening film-coating formulations is essential to ensure the desired properties are achieved, including uniformity, stability, and…

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Developing Tablet Formulations for Screening How to Develop Tablet Formulations for Screening Formulating Tablets for Effective Drug Delivery and Patient Compliance Tablet formulations are one of the most common dosage forms for oral drug delivery. They offer ease of administration, precise dosing, and cost-effectiveness. Developing tablet formulations for screening is crucial for evaluating the drug’s…

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Screening Injectable Formulations Guide to Screening Injectable Formulations Ensuring Stability, Efficacy, and Safety in Parenteral Drug Delivery Injectable formulations are an essential drug delivery system for many therapeutic agents, particularly for drugs that cannot be effectively delivered orally. Screening injectable formulations is crucial for ensuring the stability, solubility, and safety of the drug for parenteral…

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Selecting Surfactants for Formulation Development How to Select Surfactants for Formulation Development Choosing the Right Surfactants for Improved Drug Delivery Surfactants play a critical role in formulation development, particularly in enhancing the solubility and bioavailability of poorly water-soluble drugs. They act as emulsifiers, solubilizers, or stabilizers, depending on the formulation type. This guide outlines how…

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