Tag: pharmaceutical troubleshooting]

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets

May 17, 2025 Admin

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the safety and integrity of drug products is paramount. Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestine, providing targeted…

Solid Dosage form, Tablets

Investigating Coating Adhesion Failures in Enteric-Coated Tablets During Testing

May 10, 2025 Admin

Investigating Coating Adhesion Failures in Enteric-Coated Tablets During Testing Investigating Coating Adhesion Failures in Enteric-Coated Tablets During Testing Introduction: Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the more neutral environment of the intestines. This targeted drug delivery system is crucial for drugs that are sensitive to stomach…

Solid Dosage form, Tablets

Troubleshooting Failures in Layer Adhesion During Bilayer Tablet Equipment Validation

May 6, 2025 Admin

Troubleshooting Failures in Layer Adhesion During Bilayer Tablet Equipment Validation Troubleshooting Failures in Layer Adhesion During Bilayer Tablet Equipment Validation Introduction: Bilayer tablets have emerged as a significant advancement in pharmaceutical dosage forms, offering the potential for controlled release, improved patient compliance, and enhanced therapeutic efficacy. However, their manufacturing presents unique challenges, particularly concerning layer…

Solid Dosage form, Tablets

Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation

May 5, 2025 Admin

Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation Managing Adhesion Failures in Sustained Release Tablet Coating Layers During Validation Introduction: Sustained release tablets are a cornerstone in modern pharmaceutical delivery systems, designed to release their active ingredient gradually over time to maintain therapeutic levels in the bloodstream. The coating on these tablets…

Solid Dosage form, Tablets

Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time

May 3, 2025 Admin

Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time Introduction: Extended release tablets are a crucial aspect of modern pharmaceutical delivery systems, offering consistent therapeutic effects over extended periods. However, the integrity of their coating is paramount to ensure proper drug release and efficacy….

Solid Dosage form, Tablets

Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage

April 30, 2025 Admin

Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Introduction: Sugar-coated tablets are a prevalent form of oral pharmaceutical dosage due to their aesthetic appeal, taste masking abilities, and protective properties. However, during storage, these tablets can sometimes develop surface roughness, which can compromise their appearance, consumer acceptance,…

Solid Dosage form, Tablets

Challenges in predicting the impact of high humidity on capsule disintegration times.

April 30, 2025 Admin

Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Deviations in Stability Studies for Bilayer Tablets

April 27, 2025 Admin

Addressing Deviations in Stability Studies for Bilayer Tablets Addressing Deviations in Stability Studies for Bilayer Tablets Introduction: Bilayer tablets have emerged as a versatile drug delivery system, offering the advantage of combining two different drugs or formulations with varied release profiles in a single dosage form. This innovation not only improves patient compliance but also…

Solid Dosage form, Tablets

Poor reproducibility in dissolution profiles for lipid-based capsules.

April 24, 2025 Admin

Poor reproducibility in dissolution profiles for lipid-based capsules. Poor reproducibility in dissolution profiles for lipid-based capsules. Introduction: Lipid-based capsules, encompassing both hard and soft gelatin varieties, are critical in the delivery of poorly water-soluble drugs. These formulations improve bioavailability, allowing for efficient drug release and absorption. However, achieving consistent dissolution profiles in lipid-based capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Over-Drying Issues in Granulation During Validation Runs

April 24, 2025 Admin

Addressing Over-Drying Issues in Granulation During Validation Runs Addressing Over-Drying Issues in Granulation During Validation Runs Introduction: In the pharmaceutical industry, granulation is a critical step in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form granules, which enhance the flowability and compressibility of the powder,…

Solid Dosage form, Tablets

Poor validation of capsule weight variation for powders with low bulk density.

April 23, 2025 Admin

Poor validation of capsule weight variation for powders with low bulk density. Poor validation of capsule weight variation for powders with low bulk density. Introduction: In the pharmaceutical industry, the formulation and manufacture of capsules are crucial for ensuring patient safety and therapeutic efficacy. Capsules, particularly solid oral dosage forms, remain a popular choice due…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule weight loss due to evaporation.

April 23, 2025 Admin

Inadequate systems for monitoring capsule weight loss due to evaporation. Inadequate Systems for Monitoring Capsule Weight Loss Due to Evaporation Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry, renowned for their ease of administration and ability to encapsulate a wide range of formulations….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms