Tag: pharmaceutical troubleshooting]

Preventing Cracking in Bilayer Tablets During Drying Stages

March 8, 2025 Admin

Preventing Cracking in Bilayer Tablets During Drying Stages Preventing Cracking in Bilayer Tablets During Drying Stages Introduction: Bilayer tablets are an innovative and efficient way to deliver multiple drugs or different release profiles in a single dosage form. They are engineered to provide controlled release, improve patient compliance, and optimize therapeutic outcomes. However, manufacturing bilayer…

Solid Dosage form, Tablets

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes

March 8, 2025 Admin

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Introduction: The pharmaceutical industry relies heavily on the integrity and efficacy of solid dosage forms like tablets. Among these, sugar-coated tablets have been traditionally used for their aesthetic appeal and ability to mask unpleasant tastes. However, the…

Solid Dosage form, Tablets

Difficulty in validating capsule sealing for capsules with multi-layer fills.

March 8, 2025 Admin

Difficulty in validating capsule sealing for capsules with multi-layer fills. Difficulty in validating capsule sealing for capsules with multi-layer fills Introduction: Capsules have long been a preferred dosage form in the pharmaceutical industry due to their versatility and convenience. The advent of multi-layer fills in capsules has paved the way for innovative drug delivery systems….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Calibration Failures in Hardness Testing Equipment

March 7, 2025 Admin

Troubleshooting Calibration Failures in Hardness Testing Equipment Troubleshooting Calibration Failures in Hardness Testing Equipment Introduction: In the pharmaceutical industry, ensuring the quality and consistency of solid dosage forms like tablets is paramount. Hardness testing equipment plays a critical role in this process by assessing the mechanical integrity of tablets, which is crucial for both efficacy…

Solid Dosage form, Tablets

Troubleshooting Moisture Loss in Coated Tablets Stored at Low Humidity

March 7, 2025 Admin

Troubleshooting Moisture Loss in Coated Tablets Stored at Low Humidity Troubleshooting Moisture Loss in Coated Tablets Stored at Low Humidity Introduction: In the pharmaceutical industry, maintaining the stability and efficacy of drug products is paramount. Coated tablets, a common solid dosage form, are often designed with specific moisture content to ensure their integrity and therapeutic…

Solid Dosage form, Tablets

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

March 7, 2025 Admin

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

Solid Dosage form, Tablets

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets

March 7, 2025 Admin

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Introduction: In the pharmaceutical industry, the production of multi-API (Active Pharmaceutical Ingredient) tablets requires precise formulation and meticulous blending to ensure each tablet meets stringent quality standards. Achieving homogeneity in powder blends is crucial for ensuring that every tablet…

Solid Dosage form, Tablets

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

March 7, 2025 Admin

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

Solid Dosage form, Tablets

Problems with validating capsule weight variation for hard gelatin capsules.

March 7, 2025 Admin

Problems with validating capsule weight variation for hard gelatin capsules. Problems with validating capsule weight variation for hard gelatin capsules. Introduction: In the pharmaceutical industry, hard gelatin capsules are a prevalent form of solid oral dosage. Ensuring the consistency of capsule weight is crucial for maintaining dosage accuracy, therapeutic efficacy, and patient safety. Variations in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Investigating Poor API Distribution in Content Uniformity Tests

March 6, 2025 Admin

Investigating Poor API Distribution in Content Uniformity Tests Investigating Poor API Distribution in Content Uniformity Tests Introduction: The pharmaceutical industry is heavily reliant on the precision and consistency of its products. One critical aspect of ensuring drug efficacy and safety is maintaining uniformity in the active pharmaceutical ingredient (API) distribution within solid dosage forms like…

Solid Dosage form, Tablets

Troubleshooting Moisture Retention in Hygroscopic Tablet Coatings

March 6, 2025 Admin

Troubleshooting Moisture Retention in Hygroscopic Tablet Coatings Troubleshooting Moisture Retention in Hygroscopic Tablet Coatings Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of solid dosage forms like tablets is paramount. Tablet coatings, especially those involving hygroscopic materials, play a crucial role in protecting the core from environmental factors such as moisture. However, moisture…

Solid Dosage form, Tablets

Inadequate methods for monitoring capsule brittleness under low humidity conditions.

March 6, 2025 Admin

Inadequate methods for monitoring capsule brittleness under low humidity conditions. Inadequate Methods for Monitoring Capsule Brittleness Under Low Humidity Conditions Introduction: Capsules, both hard and soft gelatin, are a prevalent form of solid oral dosage forms in the pharmaceutical industry. Ensuring their integrity and efficacy is crucial for therapeutic effectiveness. One of the significant challenges…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms