Tag: pharmaceutical troubleshooting]

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets

June 2, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or achieve controlled release profiles. However, these complex formulations often face challenges, particularly with the adherence of coating layers. Ensuring that…

Solid Dosage form, Tablets

Troubleshooting Over-Lubrication in Powder Blends During Compression Validation

June 1, 2025 Admin

Troubleshooting Over-Lubrication in Powder Blends During Compression Validation Troubleshooting Over-Lubrication in Powder Blends During Compression Validation Introduction: In the pharmaceutical industry, the production of tablets is a complex process that demands precision and careful attention to detail. One critical aspect of tablet manufacturing is the lubrication of powder blends, which facilitates the tablet compression process….

Solid Dosage form, Tablets

Resolving Brittleness in Immediate Release Tablets During Long-Term Storage

May 26, 2025 Admin

Resolving Brittleness in Immediate Release Tablets During Long-Term Storage Resolving Brittleness in Immediate Release Tablets During Long-Term Storage Introduction: Immediate release tablets are a cornerstone of pharmaceutical dosage forms, designed to disintegrate promptly after administration to ensure rapid drug release. However, maintaining their integrity during long-term storage poses significant challenges. One of the most critical…

Solid Dosage form, Tablets

Addressing Failures in Weight Variation Control During Compression Equipment Validation

May 26, 2025 Admin

Addressing Failures in Weight Variation Control During Compression Equipment Validation Addressing Failures in Weight Variation Control During Compression Equipment Validation Introduction: In the pharmaceutical industry, ensuring the consistency and quality of products is paramount, especially when it comes to solid dosage forms such as tablets. One critical aspect of tablet manufacturing is weight variation control…

Solid Dosage form, Tablets

Root Cause Analysis of Weight Variation in Tablets During Stability Storage

May 24, 2025 Admin

Root Cause Analysis of Weight Variation in Tablets During Stability Storage Root Cause Analysis of Weight Variation in Tablets During Stability Storage Introduction: In the pharmaceutical industry, tablets remain one of the most common solid dosage forms, prized for their convenience, stability, and precise dosing. However, a critical aspect of tablet production and storage is…

Solid Dosage form, Tablets

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing

May 22, 2025 Admin

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Introduction: Enteric-coated tablets are an essential dosage form in the pharmaceutical industry, designed to withstand the acidic environment of the stomach and release active ingredients in the more neutral environment of the intestine. This protective mechanism not only enhances…

Solid Dosage form, Tablets

Troubleshooting Failures in Compression Force Validation for High-Speed Presses

May 22, 2025 Admin

Troubleshooting Failures in Compression Force Validation for High-Speed Presses Troubleshooting Failures in Compression Force Validation for High-Speed Presses Introduction: In the fast-paced world of pharmaceutical manufacturing, high-speed tablet presses are indispensable assets that enable large-scale production of solid dosage forms. These machines are designed to efficiently compress powders into tablets, making them crucial in meeting…

Solid Dosage form, Tablets

Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation

May 21, 2025 Admin

Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation Addressing Layer Delamination Issues in Multi-Layer Tablets During Equipment Validation Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or release profiles in a single dose. However, as beneficial as these tablets are, they come with…

Solid Dosage form, Tablets

Troubleshooting Brittleness in Coated Tablets During Validation Testing

May 21, 2025 Admin

Troubleshooting Brittleness in Coated Tablets During Validation Testing Troubleshooting Brittleness in Coated Tablets During Validation Testing Introduction: In the pharmaceutical industry, tablets are a common and vital dosage form. They offer precise dosing, ease of administration, and stability. However, the process of coating tablets, which enhances their appearance, taste, and stability, can introduce challenges. One…

Solid Dosage form, Tablets

Troubleshooting Non-Adherence to Visual Inspection Standards During Equipment Validation

May 18, 2025 Admin

Troubleshooting Non-Adherence to Visual Inspection Standards During Equipment Validation Troubleshooting Non-Adherence to Visual Inspection Standards During Equipment Validation Introduction: In the pharmaceutical manufacturing industry, particularly in the production of solid dosage forms like tablets, maintaining rigorous quality control is paramount. One of the key components of quality assurance is adhering to visual inspection standards during…

Solid Dosage form, Tablets

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation

May 17, 2025 Admin

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Introduction: In the pharmaceutical industry, tablet formulation and manufacturing represent critical processes that significantly impact the quality, efficacy, and safety of the final product. High-dose tablets are particularly challenging to develop due to the increased risks of brittleness, which…

Solid Dosage form, Tablets

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets

May 17, 2025 Admin

Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Addressing Problems in Tamper-Evident Sealing for Enteric-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the safety and integrity of drug products is paramount. Enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestine, providing targeted…

Solid Dosage form, Tablets