Tag: pharmaceutical stability

Common Issues in Batch Sampling for Quality Testing of Tablets

March 19, 2025 Admin

Common Issues in Batch Sampling for Quality Testing of Tablets Common Issues in Batch Sampling for Quality Testing of Tablets Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of tablet batches is paramount. Batch sampling is a critical process that involves selecting a representative sample from a production batch to assess the quality…

Solid Dosage form, Tablets

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets

March 18, 2025 Admin

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Introduction: In the world of pharmaceuticals, the stability and efficacy of tablets are of utmost importance. Hygroscopic tablets, which have a tendency to absorb moisture from the environment, pose unique challenges in maintaining their integrity and functionality. Moisture sensitivity can lead…

Solid Dosage form, Tablets

Poor reproducibility in microbial stability results for capsules stored in high-humidity environments.

March 15, 2025 Admin

Poor reproducibility in microbial stability results for capsules stored in high-humidity environments. Poor Reproducibility in Microbial Stability Results for Capsules Stored in High-Humidity Environments Introduction: Microbial stability is a critical aspect of pharmaceutical product development, particularly for solid oral dosage forms like capsules. Ensuring the reliability and consistency of microbial stability results is essential to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with monitoring moisture migration within capsule shells.

March 15, 2025 Admin

Problems with monitoring moisture migration within capsule shells. Problems with Monitoring Moisture Migration Within Capsule Shells Introduction: In the pharmaceutical industry, ensuring the integrity and stability of solid oral dosage forms is paramount. Capsules, whether hard or soft gelatin, are widely used due to their ease of administration and ability to encapsulate a variety of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles

March 15, 2025 Admin

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their aesthetic appeal and ability to mask the taste of active pharmaceutical ingredients (APIs). However, the stability of these tablets can be significantly challenged…

Solid Dosage form, Tablets

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

March 14, 2025 Admin

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

Solid Dosage form, Tablets

Troubleshooting Variability in Dissolution Profiles During Stability Studies

March 14, 2025 Admin

Troubleshooting Variability in Dissolution Profiles During Stability Studies Troubleshooting Variability in Dissolution Profiles During Stability Studies Introduction: Dissolution testing is a critical aspect of pharmaceutical development, acting as a quality control measure to ensure that tablets release their active ingredients at the intended rate and extent. During stability studies, the variability in dissolution profiles can…

Solid Dosage form, Tablets

Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage

March 14, 2025 Admin

Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage Troubleshooting Loss of Moisture Control in Hygroscopic Tablet Storage Introduction: In the pharmaceutical industry, maintaining the integrity of solid dosage forms, particularly hygroscopic tablets, is crucial. Hygroscopic tablets are designed to absorb moisture from the environment, making them particularly vulnerable to degradation if not stored properly….

Solid Dosage form, Tablets

High variability in stability data for oil-filled capsules.

March 12, 2025 Admin

High variability in stability data for oil-filled capsules. High variability in stability data for oil-filled capsules. Introduction: In the pharmaceutical industry, maintaining the stability of medicinal products is crucial to ensure their safety, efficacy, and quality over their shelf life. Among various dosage forms, oil-filled capsules—encompassing both hard and soft gelatin variants—present unique challenges in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between accelerated and real-time stability results.

March 12, 2025 Admin

Poor correlation between accelerated and real-time stability results. Poor correlation between accelerated and real-time stability results. Introduction: Stability testing is an essential component of the pharmaceutical development process. It ensures that a drug product maintains its intended physical, chemical, microbiological, and therapeutic properties throughout its shelf life. Accelerated stability testing and real-time stability testing are…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of robust methods for real-time moisture content monitoring in capsules.

March 11, 2025 Admin

Lack of robust methods for real-time moisture content monitoring in capsules. Lack of robust methods for real-time moisture content monitoring in capsules. Introduction: Moisture content within pharmaceutical capsules is a critical quality attribute that can significantly affect the product’s efficacy, stability, and shelf life. Both hard and soft gelatin capsules are particularly susceptible to moisture…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Issues in Stability Testing for Immediate Release Tablets

March 11, 2025 Admin

Resolving Issues in Stability Testing for Immediate Release Tablets Resolving Issues in Stability Testing for Immediate Release Tablets Introduction: Stability testing is a critical component in the development and lifecycle management of pharmaceutical products. For immediate release tablets, which are designed to disintegrate and release their active ingredients promptly upon administration, ensuring stability is paramount….

Solid Dosage form, Tablets