Tag: pharmaceutical stability

Challenges in determining the impact of low-temperature storage on capsule shells.

April 7, 2025 Admin

Challenges in determining the impact of low-temperature storage on capsule shells. Challenges in determining the impact of low-temperature storage on capsule shells. Introduction: The pharmaceutical industry significantly relies on capsules as a solid oral dosage form due to their versatility and effectiveness in delivering active pharmaceutical ingredients (APIs). Capsules, whether hard or soft gelatin, provide…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation of capsule storage and handling procedures.

April 7, 2025 Admin

Inadequate validation of capsule storage and handling procedures. Inadequate Validation of Capsule Storage and Handling Procedures Introduction: In the pharmaceutical industry, the storage and handling of capsules are critical to ensuring their efficacy and safety. Capsules, whether hard or soft gelatin, are delicate and require specific environmental conditions to maintain their integrity and therapeutic value….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent capsule sealing over long-term storage.

April 5, 2025 Admin

Difficulty in ensuring consistent capsule sealing over long-term storage. Difficulty in Ensuring Consistent Capsule Sealing Over Long-Term Storage Introduction: Capsules, whether hard or soft gelatin, are a popular solid oral dosage form used in the pharmaceutical industry for their ease of use and ability to encapsulate a range of substances. However, ensuring consistent capsule sealing…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with capsule stability testing guidelines.

April 5, 2025 Admin

Difficulty in ensuring compliance with capsule stability testing guidelines. Difficulty in ensuring compliance with capsule stability testing guidelines. Introduction: In the pharmaceutical industry, ensuring the stability of solid oral dosage forms, particularly capsules, is crucial for maintaining the efficacy, safety, and quality of medications throughout their shelf life. Capsule stability testing serves as a fundamental…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting minor shell deformities under stability conditions.

April 5, 2025 Admin

Problems with detecting minor shell deformities under stability conditions. Problems with detecting minor shell deformities under stability conditions. Introduction: In the pharmaceutical industry, the stability of solid oral dosage forms, such as capsules, is paramount to ensuring the effectiveness and safety of medications. Capsules, whether hard or soft gelatin, can be susceptible to minor shell…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Overwrapping Problems in Sustained Release Tablets

April 4, 2025 Admin

Troubleshooting Overwrapping Problems in Sustained Release Tablets Troubleshooting Overwrapping Problems in Sustained Release Tablets Introduction: In the pharmaceutical industry, the packaging of sustained release tablets is a critical component that ensures product efficacy, stability, and safety. Overwrapping, a common packaging method, plays a vital role in protecting these tablets from environmental factors, preserving their intended…

Solid Dosage form, Tablets

Poor reproducibility in gelatin cross-linking data under various storage conditions.

April 4, 2025 Admin

Poor reproducibility in gelatin cross-linking data under various storage conditions. Poor Reproducibility in Gelatin Cross-Linking Data Under Various Storage Conditions Introduction: In the pharmaceutical industry, the stability and integrity of solid oral dosage forms, particularly capsules, are paramount. Gelatin, a common excipient used in hard and soft capsules, undergoes a process known as cross-linking, which…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies

April 3, 2025 Admin

Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies Troubleshooting Root Cause Analysis for Non-Adherence in Stability Studies Introduction: Stability studies are a crucial component of the pharmaceutical development process, ensuring that drug products maintain their intended quality, safety, and efficacy throughout their shelf life. Non-adherence to stability protocols can lead to significant issues, including…

Solid Dosage form, Tablets

Poor reproducibility in gelatin elasticity data under various storage conditions.

March 31, 2025 Admin

Poor reproducibility in gelatin elasticity data under various storage conditions. Poor reproducibility in gelatin elasticity data under various storage conditions. Introduction: Gelatin capsules, both hard and soft gelatin, are pivotal in the pharmaceutical industry as they offer a stable and effective medium for drug delivery. However, the elasticity of gelatin, a critical factor in capsule…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

March 22, 2025 Admin

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

Solid Dosage form, Tablets

Inadequate validation of capsule performance under variable storage conditions.

March 22, 2025 Admin

Inadequate validation of capsule performance under variable storage conditions. Inadequate validation of capsule performance under variable storage conditions Introduction: In the pharmaceutical industry, ensuring the stability and performance of dosage forms, such as capsules, under varying storage conditions is crucial. Capsules, whether hard or soft gelatin, are popular for their ease of administration and ability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets

March 20, 2025 Admin

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Introduction: In the pharmaceutical industry, stability studies play a crucial role in ensuring the efficacy, safety, and quality of drug products. For film-coated tablets, stability studies are essential to evaluate how the product maintains its intended physical, chemical, microbiological,…

Solid Dosage form, Tablets