Tag: pharmaceutical stability

High variability in sealing strength for capsule containers.

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High variability in sealing strength for capsule containers. High variability in sealing strength for capsule containers. Introduction: In the pharmaceutical industry, ensuring the quality and integrity of solid oral dosage forms is paramount. Capsule containers, especially hard and soft gelatin capsules, are widely used due to their convenience and efficiency in drug delivery. However, one…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Temperature Fluctuations in Stability Testing Chambers

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Managing Temperature Fluctuations in Stability Testing Chambers Managing Temperature Fluctuations in Stability Testing Chambers Introduction: Stability testing is a critical component of the pharmaceutical development process, ensuring that drug products maintain their intended quality, safety, and efficacy throughout their shelf life. Central to this process are stability testing chambers, which simulate various environmental conditions to…

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Solid Dosage form, Tablets

Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets

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Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets Introduction: Active Pharmaceutical Ingredients (APIs) are the heart of any medication, providing the therapeutic effect intended for the patient. In the realm of solid dosage forms, particularly tablets, preserving the stability of APIs is crucial. Temperature-sensitive tablets,…

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Solid Dosage form, Tablets

Challenges in assessing stability of capsules with non-aqueous fills.

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Challenges in assessing stability of capsules with non-aqueous fills. Challenges in assessing stability of capsules with non-aqueous fills. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms. However, when these capsules are filled with…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in maintaining consistent capsule hardness over the stability period.

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Difficulty in maintaining consistent capsule hardness over the stability period. Difficulty in maintaining consistent capsule hardness over the stability period. Introduction: Capsules, both hard and soft gelatin, are a prevalent form of oral dosage in the pharmaceutical industry due to their versatility and patient compliance. However, maintaining consistent hardness throughout the stability period is a…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting changes in gelatin plasticizer levels during stability testing.

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Problems with detecting changes in gelatin plasticizer levels during stability testing. Problems with Detecting Changes in Gelatin Plasticizer Levels During Stability Testing Introduction: In the pharmaceutical industry, solid oral dosage forms, particularly gelatin capsules, are prevalent due to their ease of use and patient compliance. However, maintaining the stability of these dosage forms is critical…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Color Changes in Film-Coated Tablets During Stability Studies

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Addressing Color Changes in Film-Coated Tablets During Stability Studies Addressing Color Changes in Film-Coated Tablets During Stability Studies Introduction: In the pharmaceutical industry, maintaining the integrity and appearance of film-coated tablets throughout their shelf life is crucial. Stability studies play a significant role in ensuring that these products meet quality standards over time. One common…

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Solid Dosage form, Tablets

High variability in the thickness of blister foil materials.

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High variability in the thickness of blister foil materials. High Variability in the Thickness of Blister Foil Materials Introduction: Blister packaging is a critical component in the pharmaceutical industry, offering protection and extended shelf life for solid oral dosage forms like capsules and tablets. However, variability in the thickness of blister foil materials can pose…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time

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Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their ability to mask unpleasant tastes and improve patient compliance. However, maintaining the potency of the Active Pharmaceutical Ingredient (API)…

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Solid Dosage form, Tablets

Poor reproducibility in weight variation measurements over extended storage.

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Poor reproducibility in weight variation measurements over extended storage. Poor reproducibility in weight variation measurements over extended storage. Introduction: In the pharmaceutical industry, ensuring the consistency and quality of solid oral dosage forms is paramount. Capsules, both hard and soft gelatin, are popular due to their ease of administration and versatility. However, maintaining their weight…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Impact of Oxidative Stress on Sugar-Coated Tablets

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Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Among the various solid dosage forms, sugar-coated tablets offer unique benefits such as taste masking and protection of active ingredients. However, these…

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Solid Dosage form, Tablets

Difficulty in maintaining proper storage conditions for packaging materials.

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Difficulty in maintaining proper storage conditions for packaging materials. Difficulty in Maintaining Proper Storage Conditions for Packaging Materials Introduction: In the pharmaceutical industry, maintaining the integrity and efficacy of products is paramount. Packaging materials, particularly for solid oral dosage forms like capsules, play a critical role in protecting the product from environmental factors and ensuring…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms