Tag: pharmaceutical R&D

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing

May 22, 2025 Admin

Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Investigating Cracking in Enteric-Coated Tablets Under Accelerated Testing Introduction: Enteric-coated tablets are an essential dosage form in the pharmaceutical industry, designed to withstand the acidic environment of the stomach and release active ingredients in the more neutral environment of the intestine. This protective mechanism not only enhances…

Solid Dosage form, Tablets

Lack of validated methods for testing capsule coatings.

April 29, 2025 Admin

Lack of validated methods for testing capsule coatings. Lack of validated methods for testing capsule coatings. Introduction: The pharmaceutical industry relies heavily on solid oral dosage forms, particularly capsules, for drug delivery. Capsules, whether hard or soft gelatin, often require coatings to enhance stability, control release, or mask taste. However, a critical gap persists in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule release profiles.

April 17, 2025 Admin

Inadequate systems for monitoring capsule release profiles. Inadequate systems for monitoring capsule release profiles. Introduction: The pharmaceutical industry is a cornerstone of modern healthcare, where ensuring the efficacy and safety of medications is paramount. Solid oral dosage forms, particularly capsules, play a significant role due to their convenience and patient compliance. However, the inadequacy of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in testing soft gelatin capsules with high oil content.

April 16, 2025 Admin

Challenges in testing soft gelatin capsules with high oil content. Challenges in testing soft gelatin capsules with high oil content Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry, offering unique advantages such as improved bioavailability and patient compliance. However, when these capsules contain high oil content, they present significant challenges…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in monitoring powder flow properties during encapsulation.

April 7, 2025 Admin

Poor reproducibility in monitoring powder flow properties during encapsulation. Poor reproducibility in monitoring powder flow properties during encapsulation. Introduction: In the pharmaceutical industry, encapsulation is a critical process for the manufacturing of solid oral dosage forms. The flow properties of powders are essential, as they determine the efficiency and consistency of the encapsulation process. Poor…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated protocols for testing highly hydrophobic APIs.

April 2, 2025 Admin

Lack of validated protocols for testing highly hydrophobic APIs. Lack of validated protocols for testing highly hydrophobic APIs. Introduction: In the pharmaceutical industry, the development and testing of Active Pharmaceutical Ingredients (APIs) are crucial for ensuring drug efficacy and safety. However, one significant challenge that researchers and formulators face is dealing with highly hydrophobic APIs,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Coating Layer Delamination in Sustained Release Tablets

March 29, 2025 Admin

Addressing Coating Layer Delamination in Sustained Release Tablets Addressing Coating Layer Delamination in Sustained Release Tablets Introduction: The pharmaceutical industry continually seeks to enhance drug delivery systems, with sustained release tablets being a significant innovation. These tablets are designed to release their active ingredients over an extended period, ensuring a consistent therapeutic effect and improved…

Solid Dosage form, Tablets

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets

March 24, 2025 Admin

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to resist the acidic environment of the stomach and release active pharmaceutical ingredients (APIs) in the more neutral pH of the intestines. This controlled release profile is…

Solid Dosage form, Tablets

Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions.

March 19, 2025 Admin

Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions. Difficulty in evaluating the stability of capsules stored under vacuum-sealed conditions. Introduction: The stability of pharmaceutical capsules is a pivotal concern for the industry, ensuring that these dosage forms maintain their efficacy and safety over the intended shelf life. With advancements in packaging technologies,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule defect trends over time.

March 16, 2025 Admin

Inadequate systems for monitoring capsule defect trends over time. Inadequate systems for monitoring capsule defect trends over time. Introduction: The pharmaceutical industry is under constant pressure to maintain high standards of quality and safety, particularly when it comes to solid oral dosage forms such as capsules. Capsules, which can be either hard or soft gelatin,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in determining capsule degradation rates under UV light exposure.

March 4, 2025 Admin

Challenges in determining capsule degradation rates under UV light exposure. Challenges in determining capsule degradation rates under UV light exposure. Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of medications is paramount. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their ease of use and patient compliance….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms